Creating a standard normal brain of phase difference enhanced imaging (PADRE) and detecting epileptic focus

• Project/Area Number: 17K10423
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Kimura Yukio 国立研究開発法人国立精神・神経医療研究センター, 病院 放射線診療部, 医長 (40742862)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: MRI / PADRE / てんかん / 位相画像 / 核磁気共鳴画像（ＭＲＩ）

Outline of Final Research Achievements

We evaluated the usefulness of focus detection by detecting statistically significant abnormalities in patients' brain MRI images by creating a standardized brain of PADRE images from brain MRI of healthy subjects.We included patients with focal cortical dysplasia (FCD), who have focal epileptic focus and frequently undergo epileptic surgery.PADRE images from preoperative MRI of patients with FCD diagnosed by epilepsy surgery were analyzed using the PADRE standardized brain and statistical methods described above.The abnormal signal areas of PADRE were compared with the actual focal areas.The results of comparative analysis of six patients with PADRE-standardized brains showed that the focal areas were consistent with the actual focal areas in patient who were difficult to identify on routine preoperative MRI images.

Academic Significance and Societal Importance of the Research Achievements

MRIのPADREを使用した標準化脳作成は、一部の症例では焦点診断に有用であった。これまでの焦点診断のMRIシーケンスに加え、PADREを追加することで焦点検出能の向上が期待できる。この標準化脳は他の疾患にも応用できるため、より広い範囲の脳神経疾患の診断補助として日常診療に役立てることができうると考える。

Research Products

• [Journal Article] Delineation of the nerve fiber bundles of the infant brain associated with aging using phase difference-enhanced imaging: a preliminary study (2020)
  • Author(s): Hiroyuki Fujii, Noriko Sato, Yukio Kimura, Atsuhiko Sugiyama, Yoko Shigemoto, Fumio Suzuki, Hiroshi Matsuda, Masayuki Sasaki, Hideharu Sugimoto
  • Journal Title: Japanese Journal of Radiology Volume: 38 Issue: 8 Pages: 731-739
  • DOI: 10.1007/s11604-020-00955-z
  • NAID: 50014569061
  • Peer Reviewed
• [Journal Article] Serial MRI alterations of pediatric patients with beta-propeller protein associated neurodegeneration (BPAN) (2020)
  • Author(s): Yukio Kimura, Noriko Sato, Akihiko Ishiyama, Yoko Shigemoto, Fumio Suzuki, Hiroyuki Fujii, Norihide Maikusa, Hiroshi Matsuda, Kenya Nishioka, Nobutaka Hattori, Masayuki Sasaki
  • Journal Title: Journal of Neuroradiology Volume: 48 Issue: 2 Pages: 88-93
  • DOI: 10.1016/j.neurad.2020.04.002
  • Peer Reviewed
• [Journal Article] Exploring the frequency and clinical background of the “zebra sign” in amyotrophic lateral sclerosis and multiple system atrophy (2019)
  • Author(s): Atsuhiko Sugiyama, Noriko Sato, Yukio Kimura, Yoko Shigemoto, Fumio Suzuki, Emiko Morimoto, Yuji Takahashi, Hiroshi Matsuda, Satoshi Kuwabara
  • Journal Title: Journal of the Neurological Sciences Volume: 401 Pages: 90-94
  • DOI: 10.1016/j.jns.2019.04.032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Radiologic and Pathologic Features of the Transmantle Sign in Focal Cortical Dysplasia: The T1 Signal Is Useful for Differentiating Subtypes. (2019)
  • Author(s): Kimura Yukio, Shioya A, Saito Y, Oitani Y, Shigemoto Y, Morimoto E, Suzuki F, Ikegaya N, Kimura Yuiko, Iijima K, Takayama Y, Iwasaki M, Sasaki M, Sato N
  • Journal Title: American journal of neuroradiology Volume: 40 Issue: 6 Pages: 1060-1066
  • DOI: 10.3174/ajnr.a6067
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Brain abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome: Evaluation by diffusional kurtosis imaging and neurite orientation dispersion and density imaging. (2019)
  • Author(s): Kimura Y, Sato N, Ota M, Shigemoto Y, Morimoto E, Enokizono M, Matsuda H, Shin I, Amano K, Ono H, Sato W, Yamamura T
  • Journal Title: Journal of Magnetic Resonance Imaging Volume: 49 Issue: 3 Pages: 818-824
  • DOI: 10.1002/jmri.26247
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] MR findings in the substantia nigra on phase difference enhanced imaging in neurodegenerative parkinsonism. (2018)
  • Author(s): Sugiyama A, Sato N, Kimura Y, Ota M, Maekawa T, Sone D, Enokizono M, Murata M, Matsuda H, Kuwabara S.
  • Journal Title: Parkinsonism & Related Disorders Volume: 48 Pages: 10-16
  • DOI: 10.1016/j.parkreldis.2017.12.021
  • Peer Reviewed / Int'l Joint Research