Single-case voxel based morphometry analysis for supporting diagnose of neurodegenerative disease

• Project/Area Number: 17K10424
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: SATO NORIKO 国立研究開発法人国立精神・神経医療研究センター, 病院 放射線診療部, 部長 (10322017)
• Co-Investigator(Kenkyū-buntansha): 松田 博史 国立研究開発法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, センター長 (90173848)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 神経変性疾患 / MRI / 頭部 / パーキンソン症候群 / Dat SCAN / DKI

Outline of Final Research Achievements

We created single-case voxel based morphometry (VBM) analysis software using 140 brain MR data from 20 to 90 years old normal controls. It can evaluate individual gray and white matter atrophy to find characteristic atrophic pattern in neurodegenerative diseases. Both chorea-acanthocytosis and Huntington's disease have lenticular atrophy and involuntary movement and it is difficult to differentiate them. We evaluated both diseases by using the single-case VBM analyasis software and showed the characteristic white matter volume loss around the basal ganglia and thalamus in only chorea-acanthocytosis patients. Single-case VBM analysis would be useful to differentiate chorea-acanthocytosis from Huntington's disease with a focus on white matter atrophy.

Academic Significance and Societal Importance of the Research Achievements

MRの３DT1WIのデータを使用したvoxel based morphometry (VBM)解析による脳の萎縮度を評価する画像解析研究は、脳の変性新患の研究において有用である。しかし各疾患群間あるいは正常群との群間比較による画像解析が一般的で、個々の患者の診断には流用し難い。今回我々は20歳以上90歳以下の140人の正常データベースをもとにソフトウェアを作成し、個々人においてハンチントン病と有棘赤血球舞踏病では異なるパターンを示し、鑑別に有用なことを示した。このソフトウェアは、より広い範囲の神経変性疾患の診断補助として日常診療に役立てることができうると考える。

Research Products

• [Journal Article] Discriminating chorea-acanthocytosis from Huntington's disease with single-case voxel-based morphometry analysis. (2020)
  • Author(s): Suzuki F, Sato N, Ota M, Sugiyama A, Shigeyamay, Morimoto E, Kimura Y, Wakasugi N, Takahashi Y, Futamura A, Kawamura M, Ono K, Nakamura M, Sano A, Watanabe Masako, Mathuda H, Abe O
  • Journal Title: J. Neurol. Sci. Volume: 408 Pages: 116545-116545
  • DOI: 10.1016/j.jns.2019.116545
  • Peer Reviewed
• [Journal Article] Brain abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome: Evaluation by diffusional kurtosis imaging and neurite orientation dispersion and density imaging. (2019)
  • Author(s): Kimura Y, Sato N, Ota M, Shigemoto Y, Morimoto E, Enokizono M, Matsuda H, Shin I, Amano K, Ono H, Sato W, Yamamura T
  • Journal Title: Journal of Magnetic Resonance Imaging Volume: 49 Issue: 3 Pages: 818-824
  • DOI: 10.1002/jmri.26247
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Chorea-acanthocytosis: Time-dependent changes of symptoms and imaging findings. (2019)
  • Author(s): Suzuki F, Sato N, Sugiyama A, Iijima K, Shigemoto Y, Morimoto E, Kimura Y, Fujii H, Takahashi Y, Nakata Y, Matsuda H, Abe O.
  • Journal Title: J Neuroradiol. Volume: 13 Issue: 6 Pages: 419-424
  • DOI: 10.1016/j.neurad.2019.11.006
  • Peer Reviewed
• [Journal Article] Quantifying iron deposition in the cerebellar subtype of multiple system atrophy and spinocerebellar ataxia type 6 by quantitative susceptibility mapping. (2019)
  • Author(s): Sugiyama A, Sato N, Kimura Y, Fujii H, Maikusa N, Shigemoto Y, Suzuki F, Morimoto E, Koide K, Takahashi Y, Matsuda H, Kuwabara S.
  • Journal Title: J Neurol Sci. Volume: 15 Pages: 407-407
  • DOI: 10.1016/j.jns.2019.116525
  • Peer Reviewed
• [Journal Article] Relationship between Autistic Spectrum Trait and Regional Cerebral Blood Flow in Healthy Male Subjects. (2018)
  • Author(s): Ota M, Matsuo J, Sato N, Teraishi T, Hori H, Hattori K, Kamio Y, Maikusa N, Matsuda H, Kunugi H.
  • Journal Title: Psychiatry Investig Volume: 10;15(10) Pages: 856-961
  • Peer Reviewed
• [Presentation] 筋萎縮性側索硬化症と多系統萎縮症におけるZebra sign (2019)
  • Author(s): 杉山淳比古、佐藤典子、木村有喜男、重本蓉子、鈴木文夫、高橋祐二、松田博史、桑原聡
  • Organizer: 第60回日本 神経学会学術大会
• [Presentation] MR imaging features of cerebellum in adult-onset neuronal intranuclear inclusion disease. (2018)
  • Author(s): Sato N, Sugiyama A, Kimura Y, Maekawa T, Sone D, Enokizono M, Saito Y, Matsuda H, Kuwabara S.
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Int'l Joint Research