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Transvenous radiofrequency ablation system for the treatment of primary aldosteronism.

Research Project

Project/Area Number 17K10431
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

Kei Takase  東北大学, 医学系研究科, 教授 (60361094)

Co-Investigator(Kenkyū-buntansha) 清治 和将  東北大学, 大学病院, 講師 (50400247)
中村 保宏  東北医科薬科大学, 医学部, 教授 (80396499)
佐藤 文俊  東北大学, 医学系研究科, 特任教授 (70343051)
森本 玲  東北大学, 大学病院, 准教授 (30547394)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords原発性アルドステロン症 / IVR / 高血圧 / ラジオ波焼灼術 / 副腎静脈サンプリング / 血管造影 / 静脈サンプリング / インターベンショナルラジオロジー(IVR) / 副腎
Outline of Final Research Achievements

We initially developed flexible type metallic ablation catheter with coop-tip system which can be inserted via a guiding sheath using over-the-wire technique. We evaluated electrical and mechanical safety, reachability to left adrenal vein via femoral vein, and ablative volume to make improvement of the system. The ablation performance was evaluated by gel-model study and ex-vivo ablation of bovine adrenal gland to establish dosimetry table. Ablation volume under blood perfusion to adrenal gland will be evaluated by in-vivo ablation of porcine adrenal grand, in which protocol of blood pressure stabilization during the ablation should also be established. Reachability of the system to human adrenal gland was also evaluated by using a real-size vascular model based on 3D-CT data. After development of this system, most of the primary aldosteronism patients will be treated low-invasively leading to reduction of severe cardiovascular complications and medical cost.

Academic Significance and Societal Importance of the Research Achievements

高血圧の原因となる原発性アルドステロン症という疾患を、血管から入れた細いカテーテルを用いて体に優しい治療を行なうための基礎的開発と検証を行なうことができた。将来の高血圧に関連した脳卒中、心筋梗塞、腎不全といった医療費を圧迫する合併症を本治療により未然に防ぐことは、薬剤費の低減を含む医療費削減をしながら、国民の健康増進に寄与すると考える。若年性高血圧も来す本疾患の根治は、働き盛りの合併症を防止することで労働力確保にも貢献する。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (33 results)

All 2020 2019 2018 2017 Other

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 6 results) Presentation (19 results) (of which Int'l Joint Research: 3 results,  Invited: 18 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Unique Sex Steroid Profiles in Estrogen-Producing Adrenocortical Adenoma Associated with Bilateral Hyperaldosteronism.2020

    • Author(s)
      Tezuka Y, Yamazaki Y, Ono Y, Morimoto R, Omata K, Seiji K, Takase K, Kawasaki Y, Ito A, Nakamura Y, Harigae H, Sasano H, Satoh F
    • Journal Title

      Journal of the Endocrine Society

      Volume: 4 Issue: 2 Pages: 1-8

    • DOI

      10.1210/jendso/bvaa004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in quality of life after laparoscopic adrenalectomy for patients with primary aldosteronism: Prospective 2‐year longitudinal cohort study in a Japanese tertiary center2019

    • Author(s)
      Ishidoya Shigeto、Kawasaki Yoshihide、Namiki Shunichi、Morimoto Ryo、Takase Kei、Ito Akihiro
    • Journal Title

      International Journal of Urology

      Volume: 26 Issue: 7 Pages: 752-754

    • DOI

      10.1111/iju.14016

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 18-Oxocortisol Synthesis in Aldosterone-Producing2019

    • Author(s)
      Yuta Tezuka, Yuto Yamazaki, Masaaki Kitada, Ryo Morimoto, Masataka Kudo, Kazumasa Seiji,
    • Journal Title

      Hypertension

      Volume: 印刷中 Issue: 6 Pages: 1283-1290

    • DOI

      10.1161/hypertensionaha.118.12064

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 3T MRI evaluation of regional catecholamine-producing tumor-induced myocardial injury2019

    • Author(s)
      Higuchi Satoshi、Ota Hideki、Ueda Takuya、Tezuka Yuta、Omata Kei、Ono Yoshikiyo、Morimoto Ryo、Kudo Masataka、Satoh Fumitoshi、Takase Kei
    • Journal Title

      Endocrine Connections

      Volume: 8 Issue: 5 Pages: 454-461

    • DOI

      10.1530/ec-18-0553

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of a notch at the distal end of a microcatheter on vein deformation in segmental adrenal venous sampling: a preliminary study using computational fluid dynamics.2019

    • Author(s)
      Kinoshita T, Seiji K, Putra NK, Watanabe T, Matsumoto S, Ohta M, Takase K
    • Journal Title

      Med Biol Eng Comput.

      Volume: MAR18 Epub Issue: 7 Pages: 1-12

    • DOI

      10.1007/s11517-019-01968-1

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of surgical treatment for acromegaly on knee MRI structural features2018

    • Author(s)
      Nezu Masahiro、Kudo Masataka、Morimoto Ryo、Ono Yoshikiyo、Omata Kei、Tezuka Yuta、Igarashi Yasuhiro、Hitachi Shin、Takase Kei、Ito Sadayoshi、Satoh Fumitoshi
    • Journal Title

      Endocrine Journal

      Volume: 65 Issue: 10 Pages: 991-999

    • DOI

      10.1507/endocrj.EJ18-0108

    • NAID

      130007501102

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Image quality and radiation dose of low-tube-voltage CT with reduced contrast media for right adrenal vein imaging2018

    • Author(s)
      Takahashi Y, Ota H, Omura K, Dendo Y, Otani K, Matsuura T, Kitani M, Seiji K, Tezuka Y, Nezu M, Ono Y, Morimoto R, Satoh F, Takasa K.
    • Journal Title

      European Journal of Radiology

      Volume: 98 Pages: 150-157

    • DOI

      10.1016/j.ejrad.2017.11.017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 画像の未来はどう進むのか2020

    • Author(s)
      高瀬 圭
    • Organizer
      第30回日本心血管画像動態学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Percutaneous and transvenous radiofrequency ablation for primary aldosteronism2019

    • Author(s)
      Kei Takase
    • Organizer
      International Symposium of Aldosterone and related Substances in Hypertension 2019 (ISARSH2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of interventional radiological treatment for primary aldosteronism utilizing rapid aldosterone analysis2019

    • Author(s)
      Kei Takase
    • Organizer
      第2回島津グローバルイノベーションサミット
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 原発性アルドステロン症:診断と治療の最前線 「原発性アルドステロン症に対するラジオ波焼灼術」2019

    • Author(s)
      高瀬 圭
    • Organizer
      第92回日本泌尿器科学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 質量分析技術が創出する最新医療2019

    • Author(s)
      高瀬 圭
    • Organizer
      第92回日本内分泌学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Clinical management of Adrenal incidentaloma Imaging analysis of adrenal incidentaloma2019

    • Author(s)
      高瀬 圭
    • Organizer
      第92回日本内分泌学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 大血管炎診断の基礎と臨床 大血管炎の形態画像診断2019

    • Author(s)
      高瀬 圭
    • Organizer
      第55回日本医学放射線学会秋季臨床大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] IVRで使う最新デバイスと技術秘技 Stent assisted coil embolizationによる臓器血流温存塞栓術2019

    • Author(s)
      高瀬 圭
    • Organizer
      第55回日本腹部救急医学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Segmental AVS から考えるアルドステロン分泌動態の多様性;PA Sendai Study レジストリーの解析よりHeterogeneity in aldosterone secretion from a viewpoint of segmental AVS2019

    • Author(s)
      森本 玲、手塚 雄太、尾股 慧、小野 美澄、清治 和将、川崎 芳英、山崎 有人、伊藤 明宏、高瀬 圭、笹野 公伸、佐藤 文俊
    • Organizer
      第92回日本内分泌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 原発性アルドステロン症のCTガイド下および経静脈的RFA開発2019

    • Author(s)
      高瀬 圭
    • Organizer
      曽根班JIVROSG 2019年度第1回全体会議
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] CT-guided and transvenous radiofrequency ablation for primary aldosteronism2019

    • Author(s)
      Kei Takase
    • Organizer
      SIR 2019 (Society of Interventional Radiology)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 質量分析計を用いた新たな副腎静脈サンプリング技術の開発と将来展望2018

    • Author(s)
      高瀬 圭
    • Organizer
      第77回日本医学放射線学会総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 副腎腫瘍に対する低侵襲治療のさらなる進歩:副腎腫瘍に対するラジオ波焼灼術2018

    • Author(s)
      高瀬 圭
    • Organizer
      第30回日本内分泌外科学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 辛いけどクセになる治験と機器開発 ー副腎RFAの経験からー2018

    • Author(s)
      高瀬 圭
    • Organizer
      第19回RFA・凍結療法研究会ランチョンセミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 原発性アルドステロン症のIVR治療2018

    • Author(s)
      高瀬 圭
    • Organizer
      第17回IVR技術交流会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 原発性アルドステロン症の次世代の治療2017

    • Author(s)
      高瀬 圭
    • Organizer
      第90回日本内分泌学会学術総会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 新しいIVRの薬事承認2017

    • Author(s)
      高瀬 圭
    • Organizer
      46回日本IVR学会総会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 技術教育セミナー「静脈サンプリング(中上級)」2017

    • Author(s)
      高瀬 圭
    • Organizer
      第46回日本IVR学会総会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 原発性アルドステロン症のIVR最新の話題2017

    • Author(s)
      高瀬 圭
    • Organizer
      Hypertension up to date
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 人体のメカニズムから学ぶ 画像診断技術学2020

    • Author(s)
      森 墾、小倉 明夫(共著:高瀬 圭)
    • Total Pages
      496
    • Publisher
      メジカルビュー社
    • ISBN
      9784758320207
    • Related Report
      2019 Annual Research Report
  • [Remarks] 原発性アルドステロン症 (副腎静脈サンプリング)

    • URL

      http://www.tuh-endocrine.net/pa.html

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Remarks] IVRによる高血圧根治術 原発性アルドステロン症の低侵襲治療

    • URL

      https://www.crieto.hosp.tohoku.ac.jp/seedlist/seed01.html

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Patent(Industrial Property Rights)] 診断画像システム2019

    • Inventor(s)
      高瀬 圭、能登原 大介、加治木 駿介
    • Industrial Property Rights Holder
      高瀬 圭(東北大学)、株式会社島津製作所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-020585
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 診断画像システム、レポート生成装置およびレポート生成方法2019

    • Inventor(s)
      高瀬 圭、能登原 大介、加治木 駿介
    • Industrial Property Rights Holder
      高瀬 圭(東北大学)、株式会社島津製作所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-020954
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 高周波治療用カテーテル2019

    • Inventor(s)
      高瀬 圭、清治 和将(森 謙二、光宗 倫彦)
    • Industrial Property Rights Holder
      高瀬 圭、清治 和将(森 謙二、光宗 倫彦)
    • Industrial Property Rights Type
      特許
    • Patent Publication Number
      2019-146909
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 経静脈的低侵襲副腎焼灼システム2018

    • Inventor(s)
      高瀬圭 森謙二 光宗倫彦
    • Industrial Property Rights Holder
      高瀬圭 森謙二 光宗倫彦
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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