Transvenous radiofrequency ablation system for the treatment of primary aldosteronism.
Project/Area Number |
17K10431
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Tohoku University |
Principal Investigator |
Kei Takase 東北大学, 医学系研究科, 教授 (60361094)
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Co-Investigator(Kenkyū-buntansha) |
清治 和将 東北大学, 大学病院, 講師 (50400247)
中村 保宏 東北医科薬科大学, 医学部, 教授 (80396499)
佐藤 文俊 東北大学, 医学系研究科, 特任教授 (70343051)
森本 玲 東北大学, 大学病院, 准教授 (30547394)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 原発性アルドステロン症 / IVR / 高血圧 / ラジオ波焼灼術 / 副腎静脈サンプリング / 血管造影 / 静脈サンプリング / インターベンショナルラジオロジー(IVR) / 副腎 |
Outline of Final Research Achievements |
We initially developed flexible type metallic ablation catheter with coop-tip system which can be inserted via a guiding sheath using over-the-wire technique. We evaluated electrical and mechanical safety, reachability to left adrenal vein via femoral vein, and ablative volume to make improvement of the system. The ablation performance was evaluated by gel-model study and ex-vivo ablation of bovine adrenal gland to establish dosimetry table. Ablation volume under blood perfusion to adrenal gland will be evaluated by in-vivo ablation of porcine adrenal grand, in which protocol of blood pressure stabilization during the ablation should also be established. Reachability of the system to human adrenal gland was also evaluated by using a real-size vascular model based on 3D-CT data. After development of this system, most of the primary aldosteronism patients will be treated low-invasively leading to reduction of severe cardiovascular complications and medical cost.
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Academic Significance and Societal Importance of the Research Achievements |
高血圧の原因となる原発性アルドステロン症という疾患を、血管から入れた細いカテーテルを用いて体に優しい治療を行なうための基礎的開発と検証を行なうことができた。将来の高血圧に関連した脳卒中、心筋梗塞、腎不全といった医療費を圧迫する合併症を本治療により未然に防ぐことは、薬剤費の低減を含む医療費削減をしながら、国民の健康増進に寄与すると考える。若年性高血圧も来す本疾患の根治は、働き盛りの合併症を防止することで労働力確保にも貢献する。
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Unique Sex Steroid Profiles in Estrogen-Producing Adrenocortical Adenoma Associated with Bilateral Hyperaldosteronism.2020
Author(s)
Tezuka Y, Yamazaki Y, Ono Y, Morimoto R, Omata K, Seiji K, Takase K, Kawasaki Y, Ito A, Nakamura Y, Harigae H, Sasano H, Satoh F
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Journal Title
Journal of the Endocrine Society
Volume: 4
Issue: 2
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Image quality and radiation dose of low-tube-voltage CT with reduced contrast media for right adrenal vein imaging2018
Author(s)
Takahashi Y, Ota H, Omura K, Dendo Y, Otani K, Matsuura T, Kitani M, Seiji K, Tezuka Y, Nezu M, Ono Y, Morimoto R, Satoh F, Takasa K.
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Journal Title
European Journal of Radiology
Volume: 98
Pages: 150-157
DOI
Related Report
Peer Reviewed
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