| Project/Area Number |
17K10436
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
吉田 耕太郎 金沢大学, 医学系, 助教 (30645130)
土屋 弘行 金沢大学, 医学系, 教授 (40227434)
南 哲弥 金沢医科大学, 医学部, 教授 (60436813)
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 免疫賦活 / 凍結療法 / 動注 / 免疫療法 / 肝癌 / 癌 / IVR / 凍結免疫 / 動脈塞栓術 / 肝動脈免疫塞栓療法 |
|---|
| Outline of Final Research Achievements |
We tried to develop new treatments that cause the abscopal effect by combining OK-432 with hepatic artery embolization therapy or cryotherapy. The verification of hepatic arterial embolization with the emulsion of OK-432 and lipiodol was abandoned because selective hepatic artery embolization of rabbits resulted in unexpectedly large infarction, and immunostimulation could not be expected. We have developed a simple freezing system for animal experiments and confirmed its cooling performance. Using the freezing system, we performed the combination therapy of OK-432 local injection and cryotherapy on the rabbit VX2 liver and subcutaneous tumor models, but the abscopal effect could not be confirmed.
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究で動物実験用に作成し冷却性能を確認した凍結システムは、簡便に作成し凍結療法を行うことができる。これを用いることにより、臨床応用の拡大が期待されている凍結療法に関して、今後さらなる探索的実験を進めることが可能となった。また、ウサギ肝動脈は容易に攣縮が生じてヒトでのTAEと異なり比較的強い塞栓となることがわかり、ウサギ肝臓を用いた経血管インターベンション実験を行っていくうえでの課題が判明した。
|
