| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The concentration of cisplatin in liver tissue was increased by performing sonoporation after simultaneously injecting cisplatin and carbon dioxide micro-nanobubbles into the hepatic artery of swine and applying ultrasonic irradiation to the surface of the liver. By increasing the cavitation effect, sonoporation at a level practical for use in vivo was achieved.
A micro-nano bubble generator was developed in this study. This micro-nano bubble generator has a structure in which syringes are connected at both ends. Physiological saline and carbon dioxide are injected into each syringe, and pumped back and forth inside the device to generate micro-nano bubbles in the saline.
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