| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
SYCE2 is one of the components of the synaptonemal complex, which is formed between homologous chromosomes to ensure their connection in meiosis. This protein is not expressed in normal mitotic cells but is aberrantly expressed at varying levels in somatic cancer cells, suggesting that it is a cancer-testis antigen. In this study, we investigated the mitotic roles of SYCE2. We found that SYCE2 insulates heterochromatin protein 1α from heterochromatin and promotes ATM-dependent DNA double-strand break repair and radioresistance. This finding suggests that SYCE2 plays a role in the link between the nuclear microenvironment and the DNA damage response in somatic cells.
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