| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Abscopal effect is tumor reduction effect outside the radiation field. Immune checkpoint inhibitors enhance the effect because PD-L1 is overexpressed in irradiated tumors. The exact mechanism of the effect has not been yet elucidated. The biggest obstacle to disclosure is no local irradiation devices for small animals developed. We first made irradiation devices using lead shield having windows for liver or one lobe of liver. However, all the mice that received a single dose of radiation with various doses were dead. Therefore, we next made a device using a 50 mL-conical tubes covered with lead tunnels, where holes were drilled for stretching one lower limb so that 8 mice could be simultaneously irradiated in the same condition. The device worked well but the “second” melanoma on the upper flank opposite to the lower limb did not show any obvious abscopal effects despite of the optimized schedule of an anti-PD-1 antibody administration starting in advance of radiation initiation.
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