Research on therapeutic effect prediction and immune response mechanism of radiotherapy for malignant lymphoma

• Project/Area Number: 17K10477
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Dokkyo Medical University
• Principal Investigator: Ejima Yasuo 獨協医科大学, 医学部, 教授 (70423233)
• Co-Investigator(Kenkyū-buntansha): 楫 靖 獨協医科大学, 医学部, 非常勤講師 (10273947) ; 平野 靖弘 獨協医科大学, 医学部, 講師 (50593191) ; 小西 圭 獨協医科大学, 医学部, 助教 (20509278)
• Project Period (FY): 2017-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 放射線治療 / 悪性リンパ腫 / 予後予測 / 腫瘍免疫 / 免疫応答 / 放射線腫瘍学 / リンパ球 / 予後指標

Outline of Final Research Achievements

We investigated palliative radiotherapy (RT) for non-Hodgkin's lymphoma, and showed that even a low dose of 8 Gy/1-2 fractions was highly effective in relieving symptoms. In addition, central nervous system (CNS) involvement of recurrent or chemotherapy-refractory hematopoietic tumors has a very poor prognosis, but cranio-spinal RT was effective in more than half of the cases, and was effective in controlling CNS involvement. Although the response duration of palliative RT is short, about 3 months, it is a very effective treatment in situations where the life prognosis is short. Decreased peripheral blood lymphocyte/monocyte ratio after irradiation is a poor prognostic factor for early progression and survival, and is useful for predicting prognosis when short-term low-dose RT is to be selected.

Academic Significance and Societal Importance of the Research Achievements

低悪性度リンパ腫の緩和照射では短期低線量照射が標準的であるが、中高度悪性リンパ腫では短期低線量照射は奏効期間が短い傾向があり、比較的高線量が必要なことも多い。適切な線量分割を選択するための効果と予後の予測法を示した本研究成果は、緩和照射の有効利用に貢献することが期待される。

Research Products

• [Presentation] 悪性リンパ腫に対する Involved site radiation therapy (2020)
  • Author(s): 江島泰生
  • Organizer: 第79回日本医学放射線学会総会
  • Invited
• [Presentation] The role of craniospinal irradiation for hematological malignancy (2019)
  • Author(s): Yasuo Ejima, Yasuhiro Hirano, Kei Konishi, Yuko Nakamura, Motoshi Ichikawa, Kinuko Mitani
  • Organizer: 3rd ILROG Educational Symposium（国際学会）
  • Int'l Joint Research
• [Presentation] 悪性リンパ腫に対する放射線治療 (2019)
  • Author(s): 江島泰生
  • Organizer: 第21回JASTRO夏季セミナー
  • Invited
• [Presentation] The role of craniospinal irradiation for hematological malignancy (2019)
  • Author(s): Yasuo Ejima, Yasuhiro Hirano, Kei Konishi, Yuko Nakamura, Motoshi Ichikawa, Kinuko Mitani
  • Organizer: 3rd ILROG Educational Symposium
  • Int'l Joint Research
• [Presentation] 造血器腫瘍に対する全脳全脊髄照射の意義についての検討 (2018)
  • Author(s): 江島 泰生、平野 靖弘、小西 圭、仲村 祐子、市川 幹、三谷 絹子
  • Organizer: 日本放射線腫瘍学会第31回学術大会
• [Presentation] 1-2回の短期緩和的放射線治療の有用性 (2018)
  • Author(s): 江島泰生、平野靖弘、小西圭、楫靖
  • Organizer: 第58回栃木県総合医学会
• [Presentation] The Association of Peripheral Blood Lymphocyte -Monocyte Ratio with Prognosis in palliative radiotherapy for non-Hodgkin lymphoma (2017)
  • Author(s): Hiroki Kawaguchi, Yasuo Ejima, et al.
  • Organizer: the 2nd ILROG Educational Conference
  • Int'l Joint Research