Clinical application of order-made radiotherapy using functional imaging for lung cancer
| Project/Area Number |
17K10478
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hiroshima University |
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Principal Investigator |
Kimura Tomoki 広島大学, 病院(医), 講師 (90379876)
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| Co-Investigator(Kenkyū-buntansha) |
永田 靖 広島大学, 医系科学研究科(医), 教授 (10228033)
角谷 倫之 東北大学, 大学病院, 助教 (20604961)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 肺機能画像 / 肺癌 / 放射線肺臓炎 / 放射線治療 / 機能画像 |
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| Outline of Final Research Achievements |
Avoidance of the functional lung region which is identified by functional imaging using intensity-modulated radiation therapy (IMRT) could have potential to reduce the incidence of severe radiation pneumonitis (RP). We prospectively investigated clinical correlations between dosimetric parameters associated with RP and functional lung imaging, and concluded that RP dosimetric parameters correlated significantly with functional lung imaging. Using further high-precise functional imaging, the correlations were more significant. Therefore, we planed the prospectively study which investigated the safety and efficacy of functional image-guided IMRT in patients with unresectable stage IIB-IIIC non-small cell lung cancer and show whether Grade 3 or higher radiation pneumonitis (Common Terminology Criteria for Adverse Events; CTCAE ver. 5.0) become less frequent. This protocol was approved by the Human Ethics Review Committee of Hiroshima University Hospital, and have started this study.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の有効性が実証されれば、実臨床において放射線肺臓炎の低減につながり、既に本格化した高齢化社会において患者の予備能に応じたオーダーメイド放射線治療の実現に貢献すると考える。また、高齢化に伴うCOPDなど合併症を有する低肺機能患者や免疫チェックポイント阻害薬との併用を予定されている患者にとって、放射線治療による有害事象を軽減する方法として期待できる研究である。
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Analysis of cardiac toxicity after definitive chemoradiotherapy for esophageal cancer using a biological dose-volume histogram2020
Author(s)
Yuki Takeuchi, YujiMurakami, Tsubasa Kameoka,Masanori Ochi, Nobuki Imano, Ippei Takahashi, Ikuno Nishibuchi, Tomoki Kimura Daisuke Kawahara, Akito Saito, Yasushi Nagata,
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Journal Title
Journal of Radiation Research
Volume: 61
Issue: 2
Pages: 298-306
DOI
Related Report
Peer Reviewed
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[Journal Article] Comparison of stereotactic body radiation therapy combined with or without transcatheter arterial chemoembolization for patients with small hepatocellular carcinoma ineligible for resection or ablation therapies.2018
Author(s)
Tomoki Kimura, Hiroshi Aikata, Yoshiko Doi, Nobuki Imano, Yuki Takeuchi, Ippei Takahashi, Ikuno Nishibuchi, Tsuyoshi Katsuta, Masahiro Kenjo, Yuji Murakami, Kazuo Awai, Kazuaki Chayama, Yasushi Nagata.
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Journal Title
Technology in Cancer Research and Treatment
Volume: 17
Pages: 1-11
DOI
Related Report
Peer Reviewed
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[Journal Article] Stereotactic body radiotherapy to treat small lung lesions clinicallydiagnosed as primary lung cancer by radiological examination: a prospective observational study.2018
Author(s)
Tetsuya Inoue, Norio Katoh, Yoichi M Ito, Tomoki Kimura, Yasushi Nagata, Kengo Kuriyama, Hiroshi Onishi, Tadamasa Yoshitake, Yoshiyuki Shioyama, Yusuke Iizuka, Koji Inaba, Koji Konishi, Masaki Kokubo, Katsuyuki Karasawa, Takuyo Kozuka, Kensuke Tanaka, Jun Sakakibara-Konishi, Ichiro Kinoshita, Hiroki Shirato
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Journal Title
Lung Cancer
Volume: 122
Pages: 107-112
DOI
Related Report
Peer Reviewed
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[Journal Article] Phase I study of stereotactic body radiation therapy for centrally located stage IA non-small cell lung cancer (JROSG10-1)2017
Author(s)
Tomoki Kimura, Yasushi Nagata, Hideyuki Harada, Shinya Hayashi, Yukinori Matsuo, Tsuyoshi Takanaka, Masaki Kokubo, Kenji Takayama, Hiroshi Onishi, Koichi Hirakawa, Yoshiyuki Shioyama, and Takeshi Ehara.
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Journal Title
Japanese Journal of Clinical Oncology
Volume: 22
Issue: 5
Pages: 849-856
DOI
Related Report
Peer Reviewed / Open Access
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