Basic research of custom-made chemo heavy-ion radiotherapy based on EGFR expression difference for lung cancer
Project/Area Number |
17K10490
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Saitama Medical University |
Principal Investigator |
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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Keywords | 重粒子線 / 抗癌剤 / 非小細胞肺癌 / 放射線治療 / アポトーシス / 増感効果 / セネッセンス / 化学療法 / 肺癌 / EGFR |
Outline of Final Research Achievements |
In addition to superb physical dose distribution, heavy-ion beam (carbon beam) has a high relative biological effectiveness against X-rays and is particularly effective for radioresistant tumors. A good local control effect has been reported for many radioresistant tumors such as head and neck non-squamous cell carcinoma and bone and soft tissue tumors, and some have been covered by insurance. In this study, we carried out a basic research of heavy-ion radiotherapy with chemotherapy for lung cancer using human lung cancer cells. It was clarified in a cultured cell experiment that the combined use of an anticancer drug used for lung cancer and heavy-ion beam irradiation enhances the cell killing effect and a synergistic effect is observed. The synergistic effect was significant with or without the EGFR mutation. The mechanism of synergistic effects involved early apoptosis after irradiation and senescence 3 days after irradiation.
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Academic Significance and Societal Importance of the Research Achievements |
重粒子線(炭素線)治療は難治性の放射線抵抗性腫瘍に対して有効であり、前立腺癌や骨軟部腫瘍、頭頸部癌(非扁平上皮癌)が保険適応となっている。物理学的線量分布と生物学的効果が極めて高い治療のため、局所効果が極めて良好で副作用の少ない治療が可能である。よって今後は死亡数の多く、局所制御効果が不良な局所進行肺癌に対しても、適応の拡大が期待される。標準的化学療法と重粒子線治療との併用の有効性が確立すれば、社会的な意義が高い。 本研究では培養細胞実験で重粒子線(炭素線)と殺細胞性抗癌剤の併用効果を確認し、相互作用のメカニズムを解明する意義の高い研究である。
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Evaluation of Quality of Life and Psychological Response in Recurrent and Metastatic Tumors Treated with Palliative Radiotherapy.2018
Author(s)
Yamano T, Takahashi T, Ueno S, Iigima Y, Nishimura K, Washizu K, Soda R, Utsumi N, Hondo M, Shimbo M, Hatanaka S, Haryu M
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Journal Title
Journal of Cancer Therapy
Volume: 9
Issue: 04
Pages: 351-361
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Simple index for validity of the evaluation point for dosimetric verification results of intensity-modulated radiation therapy using a Farmer-type ionization chamber.2018
Author(s)
Hatanaka S, Shimbo M, Hariu M, Nakajima G, Todoroki K, Hosaka K, Watanabe T, Washizu K, Utsumi N, Yamano T, Nishimura K, Takahashi T.
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Journal Title
Journal of X-Ray Science and Technology.
Volume: 26
Issue: 3
Pages: 473-480
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Retrospective analysis of multi-institutional, patient-specific treatment planning results of high-dose-rate intracavitary brachytherapy for gynecological cancer using V100.2018
Author(s)
Watanabe T, Miyashita H, Notake R, Todoroki K, Nakajima G, Washizu K, Utsumi N, Hatanaka S, Hariu M, Yamano T, Nishimura K, Shimbo M, Takahashi T.
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Journal Title
Australasian Physical & Engineering Sciences in Medicine.
Volume: 41
Issue: 4
Pages: 1069-1074
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Japanese expert panel meeting on the management of prostate cancer with bone metastases.2018
Author(s)
Takahashi S, Kinuya S, Nonomura N, Shinohara N, Suzuki K, Suzuki H, Nakamura K, Satoh T, Tateishi U, Yoneda T, Horikoshi H, Igawa T, Kamei T, Koizumi M, Kosaka T, Matsubara N, Miyake H, Mizokami A, Mizowaki T, Nakamura N, Nozawa M, Takahashi T, Uemura H, Uemura M, Yokomizo A, Yoshimura A, Kakehi Y.
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Journal Title
Oncol Ther.
Volume: 6
Issue: 2
Pages: 157-171
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prospective observational study of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck.2017
Author(s)
Shirai K, Saitoh J, Musha A, Abe T, Kobayashi D, Takahashi T, Tamaki T, Kawamura H, Takayasu Y, Shino M, Toyoda M, Takahashi K, Hirato J, Yokoo S, Chikamatsu K, Ohno T, Nakano T
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Journal Title
Cancer Science
Volume: 108
Issue: 10
Pages: 2039-2044
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Hypofractionated stereotactic radiotherapy for inoperable arteriovenous malformations.2019
Author(s)
Takahashi T, Yamano T, Nishimura K, Ueno S, Washizu K, Soda R, Kondo S, Utsumi N, Shimbo M, Hatanaka S, Hariu M
Organizer
ESTRO 38
Related Report
Int'l Joint Research
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[Presentation] Prediction of preoperative hyperthermo-chemoradiotherapy response in locally advanced rectal cancer.2018
Author(s)
3.Takahashi T, Murata H, Shoji H, Onishi M, Takakusaki Y, Okonogi N, Okazaki A, Nishimura K, Yamano T, Ogoshi K, Nakano T.
Organizer
ESTRO 37
Related Report
Int'l Joint Research
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[Presentation] Palliative radiotherapy for breast cancer with skin invasion: A multi-institutional prospective observational study2017
Author(s)
Nakamura N, Kawamori J, Takahashi O, Shikama N, Sekiguchi K, Takahashi T, Kato S, Ogita M, Haga C, Ito R, Nishimura K, Yamano T, Yoshida K, Motegi A, Akimoto T
Organizer
Annual Meeting of the American Society for Radiation Oncology
Related Report
Int'l Joint Research
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