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Establishment of Strategies of Precision Medicine for Oligometastases Treated with Radiotheapy

Research Project

Project/Area Number 17K10494
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKurume University (2020-2023)
Okayama University (2019)
Toho University (2017-2018)

Principal Investigator

Niibe Yuzuru  久留米大学, 医学部, 客員教授 (00372912)

Co-Investigator(Kenkyū-buntansha) 神宮 啓一  東北大学, 医学系研究科, 教授 (00451592)
島田 英昭  東邦大学, 医学部, 教授 (20292691)
山下 英臣  東京大学, 医学部附属病院, 准教授 (70447407)
谷原 真一  久留米大学, 医学部, 教授 (40285771)
片岡 仁美  岡山大学, 大学病院, 教授 (20420490)
高橋 侑子  岡山大学, 大学病院, 講師 (90892191)
Project Period (FY) 2017-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsOligometastases / oligo-recurrence / sync-oligometastases / 局所制御率(LC) / 全生存率(OS) / 腎癌Oligo-recurrence / oligometastases / oligo-progression / Oligo-recurrence / SBRT / 乳癌 / 局所制御 / FOPD / CSD / 大腸腺癌 / 食道癌 / 個別化治療戦略 / 肺oligometastases / 食道癌oligo-recurrence / 個別化治療 / 放射線治療
Outline of Final Research Achievements

We carried out the task of establishing an individualized treatment strategy for oligometastases, and many results were obtained. Broadly speaking, stereotactic body radiotherapy (SBRT) for lung oligometastases is determined by type of oligometastases (Oligo-recurrence and Sync-oligometastases), individualized treatment strategies for each cancer type (esophageal cancer, colorectal cancer), and dose increase. Using causal inference, we were able to show, for the first time in the world, data from a large database of 1378 cases that improved local treatment results by local treatment of pulmonary oligometastases lead to longer overall survival (OS).

Academic Significance and Societal Importance of the Research Achievements

大きな学術的意義や社会的意義として、Oligometastasesを分類する際に、Oligo-recurrenceとSync-Oligometastasesに分類する意義が統計学的有意差をもってOligo-recurrenceの方が予後良好ということで示せた。がん種毎に同じ肺Oligometastasesでも治療成績が異なることが示せた。再発/転移がんであるOligometastasesでもLCの向上がOSの向上につながることが示せた。腎癌Oligo-recurrenceにおいて、ガイドラインの礎を示せた。
上記4点にまとめられる

Report

(8 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (24 results)

All 2023 2021 2020 2018 2017 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 8 results) Presentation (9 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Remarks (2 results)

  • [Journal Article] The diagnosis and treatment approach for oligo-recurrent and oligo-progressive renal cell carcinoma2023

    • Author(s)
      Bekku K, Kawada T, Sekito T, Yoshinaga K, Maruyama Y, Yamanoi T, Sadahira T, Katayama S, Iwata T, Nishimura S, Edamura K, Kobayashi T Kobayashi Y, Araki M, Niibe Y
    • Journal Title

      Cancers (Basel)

      Volume: 15 Pages: 5873-5873

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of the local control of pulmonary oligometastases after stereotactic body radiotherapy and the impact of local control on survival2020

    • Author(s)
      Yamamoto T, Niibe Y, Aoki M, Shintani T, Yamada K, Kobayashi M, Yamashita H, Ozaki M, Manabe Y, Onishi H, Yahara K, Nishikawa A, Katsui K, Oh R-J, Terahara A, Jingu K
    • Journal Title

      BMC Cancer

      Volume: 20 Issue: 1 Pages: 997-997

    • DOI

      10.1186/s12885-020-07514-9

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significant reduction of oncologic pulmonary death by local control for pulmonary oligometastases treated with stereotactic body radiotherapy2020

    • Author(s)
      Yamamoto Takaya、Niibe Yuzuru、Yamada Kazunari、Aoki Masahiko、Onishi Hiroshi、Katsui Kuniaki、Dekura Yasuhiro、Nishikawa Atsushi、Manabe Yoshihiko、Yamashita Hideomi、Jingu Keiichi
    • Journal Title

      Radiotherapy and Oncology

      Volume: 147 Pages: 86-91

    • DOI

      10.1016/j.radonc.2020.03.019

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors related to primary cancer death and non-primary cancer death in patients treated with stereotactic body radiotherapy for pulmonary oligometastases2020

    • Author(s)
      Yamamoto T, Niibe Y, Matsumoto Y, Aoki Y, Oh R-J, Ozaki M, Kobayashi M, Manabe Y, Shintani T, Dekura Y, Onishi H, Yamashita H, Jingu K
    • Journal Title

      Cancer Med

      Volume: 9 Issue: 23 Pages: 8902-8911

    • DOI

      10.1002/cam4.3508

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analyses of local control and survival after stereotactic body radiotherapy for pulmonary oligometastases from colorectal adenocarcinoma2020

    • Author(s)
      Yamamoto T, Niibe Y, Matsumoto Y, Onishi H, Aoki Y, Nishikawa A, Oh R-J, Shitani T, Yahara K, Ozaki M, Manabe Y, Jingu K
    • Journal Title

      J Radiat Res

      Volume: 61 Issue: 6 Pages: 935-944

    • DOI

      10.1093/jrr/rraa071

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stereotactic Body Radiotherapy for Pulmonary Oligometastases from Esophageal Cancer: Results and Prognostic Factors2020

    • Author(s)
      YAMAMOTO TAKAYA、NIIBE YUZURU、MATSUMOTO YASUO、DEKURA YASUHIRO、OH RYOONG-JIN、YAMASHITA HIDEOMI、KAKUHARA HISAO、AOKI MASAHIKO、JINGU KEIICHI
    • Journal Title

      Anticancer Research

      Volume: 40 Issue: 4 Pages: 2065-2072

    • DOI

      10.21873/anticanres.14164

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oligometastasesの謎に迫る - Abscopal effectの関与も視野に入れて2020

    • Author(s)
      新部 譲
    • Journal Title

      泌尿器外科

      Volume: 33 Pages: 925-929

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pulomary oligometastases treated by stereotactic body radiaiont therapy: a nationwide survey of 1,378 patients.2020

    • Author(s)
      Niibe Y, Yamamoto T, Onishi H, Yamashita H, Katsui K, Matsumoto Y, Oh R, Aoki M, Shintani T, Yamada K, Kobayashi M, Ozaki M, Manabe M, Yahara K, Nishikawa A, Kakuhara H, Yamamoto K, Inoue T, Takada YU, Nagata K, Suzuki O, Terahara A, Jingu K
    • Journal Title

      Anticancer Res

      Volume: 40 Pages: 393-399

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significant reduction of oncologic pulmonary death by local control for pulmonary oligometastases treated with stereotactic body radiotherapy2020

    • Author(s)
      Yamamoto T, Niibe Y, Yamada K, Aoki M, Onishi H, Katsui K, Dekura Y, Nishikawa A, Manabe Y, Yamasshita H, Jingu K
    • Journal Title

      Radiother Oncol

      Volume: 147 Pages: 86-91

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Olligo-recurrence and sync-oligometastases2018

    • Author(s)
      Niibe Y, Jingu K, Onishi H
    • Journal Title

      Jorunal of Thoracic Onocology

      Volume: 13

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Local contorol analyses of pulmonary oligometastases treated by stereotactic body radiation therapy (SBRT) from a multi-institutional survey2018

    • Author(s)
      Yamamoto T, Niibe Y, Aoki M, Shintani T, Yamada K, Kobayashi M, Yamashita H, Ozaki M, Manabe Y, Onishi H, Yahara K, Nishikawa A, Katsui K, Terahara A, Jingu K
    • Journal Title

      International Journal of Radiation Oncology Biology Physics

      Volume: 102 Issue: 3 Pages: S11-S12

    • DOI

      10.1016/j.ijrobp.2018.06.121

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dose Escalation Improves Outcome in Stereotactic Body Radiotherapy for Pulmonary Oligometastases from Colorectal Cancer2017

    • Author(s)
      Jingu K, Matsuo Y, Onishi H, Yamamoto T, Aoki M, Murakami Y, Yamashita H, Kakuhara H, Nemoto K, Sakayauchi T, Okamoto M, Niibe Y, Nagata Y, Ogawa K
    • Journal Title

      Anticancer Research

      Volume: 37 Pages: 2709-2713

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Re-irradiation for oligo-recurrence from esophageal cancer with radiotherapy history: a multi-institutional study2017

    • Author(s)
      Jingu K, Niibe Y, Yamashita H, Katsui K, Matsumoto T, Nishina T, Terahara A
    • Journal Title

      Radiat Oncol

      Volume: 12 Issue: 1 Pages: 146-146

    • DOI

      10.1186/s13014-017-0882-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 乳癌の肺Oligometastasesに対する体幹部定位放射線治療(SBRT):56例での検討2021

    • Author(s)
      新部 譲, 山本貴也, 呉隆進, 大西洋, 勝井邦彰, 山下英臣, 寺原敦朗, 片岡仁美, 高橋侑子, 谷原真一, 神宮啓一
    • Organizer
      日本放射線腫瘍学会第34回学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Oligometastasesの発祥の背景から現在の分類および展望まで2020

    • Author(s)
      新部 譲
    • Organizer
      第61回 日本肺癌学会学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 骨oligometastasesに対する放射線治療成績2018

    • Author(s)
      新部 譲, 寺原敦朗
    • Organizer
      第56回 日本癌治療学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 食道癌リンパ節oligo-recurrenceに対する放射線療法:対象群を変更しての再検討2018

    • Author(s)
      新部 譲, 神宮啓一, 山下英臣, 松本俊彦, 仁科智裕, 勝井邦彰, 中川恵一, 金澤 右, 寺原敦朗
    • Organizer
      日本放射線腫瘍学会第31回学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Local contorol of analyses of pulmonary oligometastases treated by stereotactic body radiation therapy (SBRT) from a multi-institutional survey2018

    • Author(s)
      Yamamoto T, Niibe Y, Aoki M, Shintani T, Yamada K, Kobayashi M, Yamashita H, Ozaki M, Manabe Y, Onishi H, Yahara K, Nishikawa A, Katsui K, Terahara A, Jingu K
    • Organizer
      60th Annual Meeting of American Society for Radiation Oncology (ASTRO 2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pulmonary oligometastases treated by stereotactic body radiation therapy (SBRT) : a nationwide survey o 1,378 patients2017

    • Author(s)
      Niibe Y, Yamamoto T, Onishi H, Yamashita H, Katsui K, Matsumoto Y, Oh R-J, Aoki M, Shintani T, Myojin M, Yamada K, Kobayashi M, Ozaki M, Manabe Y, Yahara K, Nishikawa A, Kakuhara H, Matsuoka Y, Yamamoto K, Fukuda T, Ushijima Y, Terahara A, Jingu K, et al
    • Organizer
      18th Wrold Conference on Lung Cancer
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Classification of Oligometastases: Oligo-recurrence and Sync-oligometastases2017

    • Author(s)
      Niibe Y, Chang JY, Jingu K, Yamashita H, Yamamoto T, Katsui K, Onishi H, Haykawa K, Terahara A, Shirato H
    • Organizer
      第76回 日本医学放射線学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Oligometastases状態の転移性肺腫瘍に対する体幹部定位放射線治療の全国調査研究2017

    • Author(s)
      新部譲, 山本貴也, 大西洋, 山下英臣, 勝井邦彰, 寺原敦朗, 神宮啓一
    • Organizer
      日本放射線腫瘍学会第30回学術大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 食道癌リンパ節oligo-recurrenceに対する放射線療法: 多施設共同研究2017

    • Author(s)
      神宮啓一, 新部譲, 山下英臣, 勝井邦彰, 松本俊彦, 仁科智裕, 寺原敦朗
    • Organizer
      第71回日本食道学会学術集会
    • Related Report
      2017 Research-status Report
  • [Remarks] 東邦大学 教育・研究データベース

    • URL

      https://gyoseki.toho-u.ac.jp/thuhp/KgApp?kyoinId=ymdggkydggy

    • Related Report
      2018 Research-status Report
  • [Remarks] 東邦大学 教育・研究業績データベース

    • URL

      http://gyoseki.toho-u.ac.jp/thuhp/KgApp?kozac=220137001&year=2017

    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2025-01-30  

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