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Real-time in vivo dosimetry for brachytherapy

Research Project

Project/Area Number 17K10496
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKansai Medical University (2020-2022)
Osaka Medical College (2017-2019)

Principal Investigator

YOSHIDA Ken  関西医科大学, 医学部, 准教授 (10463291)

Co-Investigator(Kenkyū-buntansha) 辻本 豊  独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 機関長・部門長クラス (90773135)
隅田 伊織  大阪大学, 大学院医学系研究科, 招へい教員 (10425431)
山崎 秀哉  京都府立医科大学, 医学(系)研究科(研究院), 教授 (50301263)
田中 英一  独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 機関長・部門長クラス (10324774)
古妻 理之  独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 機関長・部門長クラス (00641870)
武中 正  京都府立医科大学, 医学(系)研究科(研究院), 助教 (80626771)
増井 浩二  京都府立医科大学, 医学(系)研究科(研究院), 助教 (20783830)
新保 大樹  大阪医科薬科大学, 医学部, 講師 (30535018)
鳴海 善文  大阪医科薬科大学, その他部局等, 名誉教授 (90273664)
門前 一  近畿大学, 大学病院, 教授 (10611593)
吉川 信彦  大阪医科薬科大学, 医学部, 非常勤講師 (10719917)
吉岡 裕人  大阪医科薬科大学, 医学部, 助教 (90779711)
Project Period (FY) 2017-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords小線源治療 / 遮蔽材 / 線量測定 / リアルタイム線量計 / VR / 組織内照射 / リアルタイム線量実測 / 放射線遮蔽材 / 放射線増感剤 / In vivo dosimetry / 不均質補正 / 放射線治療物理学 / 高線量率小線源治療 / リアルタイム実測 / 3次元画像誘導治療計画
Outline of Final Research Achievements

Because ofCOVID-19 pandemic, we could not do experiment with many researchers together. We also research about shielding device. Lead-block has a shortage of toxicity to human, we found Tangsten with rubber. It allowed us to change its shape, and so, it means that it can be used for patient's body. We started the dosimetry of Tangsten.
We wrote some articles. One of them was about inhomogenous correction. Using clinical tongue brachytherapy data, we compared the shielding effect between silicon and lead. As a result, lead reduced the mandibral bone doses about a half value compared with silicon.

Academic Significance and Societal Importance of the Research Achievements

小線源治療が最も評価されている点は、腫瘍に十分な放射線量を投与しておきながら、隣接する正常組織にはあまり高線量の被曝がないようにできる点である。それをさらに改善させるために遮蔽材を用いる事は既に行われていた。しかし、実測できるシステムはほとんどない。本研究では、まず計算上の危険臓器の線量を数値化したが、このように可視化することで、学術的な価値もさることながら、この数値化により医療者・患者が同法を希望することになり、社会的にも影響が大きい。今後、Real-timeの線量測定に進んでいくが、それが計算値と一致すると証明されるとさらに影響は大きくなると考える。

Report

(7 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (26 results)

All 2023 2022 2020 2019 2018 2017

All Journal Article (13 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 12 results,  Open Access: 6 results) Presentation (12 results) (of which Int'l Joint Research: 3 results) Book (1 results)

  • [Journal Article] HDR-brachytherapy for accelerated partial breast irradiation: Long-term experience from a Japanese institution2023

    • Author(s)
      Yoshida K、Kotsuma T、Takaoka Y、Tamenaga S、Yamazaki H、Nose T、Murakami N、Inaba K、Akiyama H、Masui K、Takenaka T、Kubota H、Tselis N、Masuda N、Yasojima H、Takeda M、Mano M、Nakamura S、Utsunomiya K、Tanigawa N、Tanaka E
    • Journal Title

      Journal of Contemporary Brachytherapy

      Volume: 15 Issue: 1 Pages: 1-8

    • DOI

      10.5114/jcb.2023.125579

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of a lead block on alveolar bone protection in image-guided high-dose-rate interstitial brachytherapy for tongue cancer: Using model-based dose calculation algorithms to correct for inhomogeneity2022

    • Author(s)
      H Akiyama, K Yoshida, T Takenaka, T Kotsuma, K Masui, H Monzen, I Sumida, Y Tsujimoto, M Miyao, H Okumura, T Shimbo, H Takegawa, N Murakami, K Inaba, T Kashihara, Z Takacsi-Nagy, N Tselis, H Yamazaki, E Tanaka, K Nihei, Y Ariji
    • Journal Title

      Journal of Contemporary Brachytherapy

      Volume: 14 Issue: 1 Pages: 87-95

    • DOI

      10.5114/jcb.2022.113232

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Japanese prospective multi-institutional feasibility study on accelerated partial breast irradiation using multicatheter interstitial brachytherapy: clinical results with a median follow-up of 60 months2022

    • Author(s)
      Yoshida K, et al.
    • Journal Title

      Breast Cancer

      Volume: 29 Issue: 4 Pages: 636-644

    • DOI

      10.1007/s12282-022-01339-z

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
  • [Journal Article] High-dose-rate interstitial brachytherapy with hypoxic radiosensitizer KORTUC II for unresectable pelvic sidewall recurrence of uterine cervical cancer: a case report.2020

    • Author(s)
      Nakata M, et al. (Corresponding author: Yoshida K)
    • Journal Title

      J Contemp Brachytherapy

      Volume: 12 Issue: 6 Pages: 606-611

    • DOI

      10.5114/jcb.2020.101695

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A new implant device to prevent edema-associated underdosage in high-dose-rate interstitial brachytherapy of mobile tongue cancer.2019

    • Author(s)
      Yoshida K, Kotsuma T, Akiyama H, Yamazaki H, Takenaka T, Masui K, Tsujimoto Y, Murakami N, Uesugi Y, Shimbo T, Yoshikawa N, Yoshioka H, Nakata M, Arika T, Takaoka Y, Tanaka E, Tselis N.
    • Journal Title

      J Contemp Brachytherapy

      Volume: 11 Issue: 6 Pages: 573-8

    • DOI

      10.5114/jcb.2019.91225

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influence of transitioning of planning techniques in high-dose-rate brachytherapy monotherapy for clinically localized prostate cancer from two- to three-dimensional planning2019

    • Author(s)
      Yamazaki Hideya、Masui Koji、Suzuki Gen、Nakamura Satoaki、Yoshida Ken、Kotsuma Tadayuki、Tanaka Eiichi、Otani Keisuke、Yoshioka Yasuo、Ogawa Kazuhiko
    • Journal Title

      Brachytherapy

      Volume: 18 Issue: 5 Pages: 589-597

    • DOI

      10.1016/j.brachy.2019.04.008

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of androgen deprivation therapy on other-cause of mortality in elderly patients with clinically localized prostate cancer treated with modern radiotherapy: Is there a negative impact?2019

    • Author(s)
      Yamazaki H, Masui K, Suzuki G, Nakamura S, Aibe N, Shimizu D, Yamada K, Okihara K, Shiraishi T, Kotsuma T, Yoshida K, Tanaka E, Otani K, Yoshioka Y, Ogawa K, Nishikawa T, Okabe H.
    • Journal Title

      J Clin Med

      Volume: 8 Issue: 3 Pages: 338-338

    • DOI

      10.3390/jcm8030338

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-dose-rate brachytherapy monotherapy versus low-dose-rate brachytherapy with or without external beam radiotherapy for clinically localized prostate cancer.2019

    • Author(s)
      Yamazaki H, Masui K, Suzuki G, Nakamura S, Yamada K, Okihara K, Shiraishi T, Yoshida K, Kotsuma T, Tanaka E, Otani K, Yoshioka Y, Ogawa K.
    • Journal Title

      Radiother Oncol

      Volume: 132 Pages: 162-170

    • DOI

      10.1016/j.radonc.2018.10.020

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of radiation dermatitis between hypofractionated and conventionally fractionated postoperative radiotherapy: objective, longitudinal assessment of skin color.2018

    • Author(s)
      Yamazaki H, Takenaka T, Aibe N, Suzuki G, Yoshida K, Nakamura S, Masui K, Kimoto T, Sasaki N, Nishimura T, Nakashima A, Goto M, Yamada K.
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 12306-12306

    • DOI

      10.1038/s41598-018-30710-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of three moderate fractionated schedules employed in high-dose-rate brachytherapy monotherapy for clinically localized prostate cancer.2018

    • Author(s)
      Yamazaki H, Masui K, Suzuki G, Nakamura S, Yoshida K, Kotsuma T, Tanaka E, Otani K, Yoshioka Y, Ogawa K.
    • Journal Title

      Radiother Oncol

      Volume: 129 Issue: 2 Pages: 370-376

    • DOI

      10.1016/j.radonc.2018.07.026

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation Between Dosimetric Parameters and Acute Dermatitis of Post-operative Radiotherapy in Breast Cancer Patients.2018

    • Author(s)
      Takenaka T, Yamazaki H, Suzuki G, Aibe N, Masui K, Shimizu D, Nishimura T, Nakashima A, Ogata T, Matsushita K, Yoshida K, Yamada K.
    • Journal Title

      In Vivo.

      Volume: 32 Pages: 1499-1504

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case report of a dose-volume histogram analysis of rib fracture after accelerated partial breast irradiation: interim analysis of a Japanese prospective multi-institutional feasibility study.2018

    • Author(s)
      Yoshida K*, Otani Y, Nose T, Yoden E, Asahi S, Tsukiyama I, Dokiya T, Saeki T, Fukuda I, Sekine H, Kumazaki Y, Takahashi T, Kotsuma T, Masuda N, Nakashima K, Matsumura T, Nakagawa S, Tachiiri S, Moriguchi Y, Itami J, Oguchi M.
    • Journal Title

      J Contemp Brachytherapy.

      Volume: 10 Pages: 274-278

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Brachytherapy for Buccal Cancer: From Conventional Low Dose Rate (LDR) or Mold Technique to High Dose Rate Interstitial Brachytherapy (HDR-ISBT)2017

    • Author(s)
      Kotsuma T, Yamazaki H, Masui K, Yoshida K, Shimizutani K, Akiyama H, Murakami S, Isohashi F, Yoshioka Y, Ogawa K, Tanaka E
    • Journal Title

      Anticancer Research

      Volume: 37 Issue: 12 Pages: 6887-6892

    • DOI

      10.21873/anticanres.12151

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 小線源治療の教育に関する将来への提言2022

    • Author(s)
      吉田謙
    • Organizer
      第24回日本放射線腫瘍学会小線源治療部会
    • Related Report
      2022 Annual Research Report
  • [Presentation] シンポジウム:舌がんに対する小線源治療は生き残れるか?2020

    • Author(s)
      吉田謙
    • Organizer
      日本頭頚部癌学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Interstitial Brachytherapy for gynecological cancer2020

    • Author(s)
      Yoshida K
    • Organizer
      PATPO(ロシア放射線腫瘍学会)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 大阪医大のKORTUC臨床経験と問題点.2020

    • Author(s)
      新保大樹、吉岡裕人、中田美緒、堀 章裕、佐藤登朗、吉田 謙.
    • Organizer
      第25回癌治療増感研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 限局性骨盤内再発癌に対するCTガイド下KORTUC治療2019

    • Author(s)
      新保大樹、吉岡裕人、中田美緒、堀章裕、佐藤登朗、沖野佳、上杉康夫、吉田謙
    • Organizer
      第32回日本放射線腫瘍学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 膀胱癌に対する動脈内投与併用化学放射線治療の初期成績2019

    • Author(s)
      吉岡裕人、新保大樹、沖野佳、堀章裕、佐藤登朗、中田美緒、上杉康夫、吉田謙
    • Organizer
      第32回日本放射線腫瘍学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 緩和療法2019

    • Author(s)
      吉田謙
    • Organizer
      第15回マイクロセレクトロンHDR研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] HDR image-guided interstitial brachytherapy for local recurrent uterine cancer.2018

    • Author(s)
      Yoshida K, Shimbo T, Yoshikawa N, Nakata M.
    • Organizer
      The 6th Taiwan-Japan Radiation Oncology Symposium.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 増感放射線療法KORTUCを用いた非手術乳房温存療法にてCRとなった5症例の検討.2018

    • Author(s)
      新保大樹、堀章裕、中田美緒、吉岡裕人、吉川信彦、吉田謙、鳴海善文、上杉康夫.
    • Organizer
      第54回日本医学放射線学会秋季臨床大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 局所再発子宮癌に対する高線量率画像誘導組織内照射の治療成績.2018

    • Author(s)
      吉田謙、新保大樹、吉川信彦、吉岡裕人、中田美緒、上杉康夫、鳴海善文.
    • Organizer
      第54回日本医学放射線学会秋季臨床大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 動物実験用X線CT装置はマウスにおける軽度の晩期放射線肺障害の検出に有用である.2018

    • Author(s)
      吉川信彦、吉田謙、新保大樹、吉岡裕人、中田美緒、堀章裕、上杉康夫、鳴海善文.
    • Organizer
      第54回日本医学放射線学会秋季臨床大会
    • Related Report
      2018 Research-status Report
  • [Presentation] HDR Image-guided Interstitial Brachytherapy for Postoperative Local Recurrent Uterine Cancer2017

    • Author(s)
      Yoshida K, Yamazaki H, Takenaka T, Kotsuma T, Masui K, Komori T, Shimbo T, Yoshikawa N, Yoshioka Y, Uesugi Y, Hamada T, NakataM, Matsutani H, Mikami Ueda M, Tsujimoto Y, Tanaka E, Narumi Y
    • Organizer
      36th ESTRO, Vienna, May
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] Interstitial Brachytherapy: Radical and Salvage Brachytherapy.2018

    • Author(s)
      Yoshida K (分担執筆).
    • Publisher
      Springer Nature Singapore Pte Ltd.
    • ISBN
      9789811304903
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2024-01-30  

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