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A novel laparoscopic near infrared spectrum system for detection of the cancer

Research Project

Project/Area Number 17K10502
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionHokkaido University

Principal Investigator

Ebihara Yuma  北海道大学, 医学研究院, 特任講師 (50632981)

Co-Investigator(Kenkyū-buntansha) 平野 聡  北海道大学, 医学研究院, 教授 (50322813)
七戸 俊明  北海道大学, 医学研究院, 准教授 (70374353)
野路 武寛  北海道大学, 大学病院, 助教 (10739296)
田中 公貴  北海道大学, 大学病院, 助教 (10758642)
李 黎明  公立千歳科学技術大学, 理工学部, 教授 (70316298)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords蛍光内視鏡 / 腹腔鏡 / 転移診断 / 5-aminolevulinic acid / 光線力学的診断 / 胃癌 / 蛍光 / 外科総論
Outline of Final Research Achievements

A comparison of fluorescent light -negative peritonea with and without pathological metastasis showed significantly higher spectrophotometry intensities of metastatic peritoneal specimens (P<0.010). In clinical studies, few fluorescent light-negative, spectrophotometry-positive, and pathological metastasis were seen among the 24 lesions of four patients. Measuring the fluorescent spectrum using laparoscopic spectrophotometry allowed the detection of fluorescence in 5-aminolevulinic acid.

Academic Significance and Societal Importance of the Research Achievements

今後の悪性腫瘍に対する手術療法においては、患者の高齢化や複数の併存症を持つ患者が増えることが予想され、早期癌に対する機能温存手術を目指したオーダーメイド手術療法と、進行難治性癌に対するリンパ節転移などの予後不良因子の選別によるスムーズな集学的治療への移行を目的とした手術療法が必要となり、同時に内視鏡手術やロボット手術などの低侵襲手術療法が選択されるようになる。そのためには、悪性腫瘍に対する光線力学的術中診断法の確立が必要であり、われわれが開発した内視鏡手術用蛍光スペクトル測定プローブがその一助となり得ると考えている。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (1 results)

All 2019

All Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] A novel laparoscopic near infrared fluorescence spectrum system is useful for intraoperative photodynamic diagnosis of peritoneal dissemination in pancreatic cancer2019

    • Author(s)
      Ebihara Y
    • Organizer
      14th Asia Pacific Congress of Endoscopic and Laparodcopic Surgery (ELSA2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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