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The optimization of the prevascularization procedures for improving subcutaneous islet engraftment introducing novel recombinant peptide

Research Project

Project/Area Number 17K10505
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionTohoku University

Principal Investigator

Inagaki Akiko  東北大学, 医学系研究科, 助教 (20360224)

Co-Investigator(Kenkyū-buntansha) 後藤 昌史  東北大学, 医学系研究科, 教授 (50400453)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords膵島移植 / 移植・再生医療 / 血管新生 / 皮下移植 / リコンビナントペプチド / 糖尿病
Outline of Final Research Achievements

Subcutaneous islet transplantation is associated with minimal invasiveness, replicability, and ready removability or re-transplantation thus attracted attention as a new site for islet transplantation. However, subcutaneous tissue involves an issue of lack of vascularization, which is important for engraftment of a transplanted islet graft. Thus, we focused on a recombinant peptide (RCP) device containing a lot of angiogenic RGD and placed the device in a subcutaneous space at a planned site for transplantation, and found that the efficiency of islet engraftment with subcutaneous transplantation was improved to a level comparable to that with intraportal transplantation.

Academic Significance and Societal Importance of the Research Achievements

皮下は低侵襲で必要に応じて摘出や再移植が容易なため、膵島の新たな移植部位として注目されているが、移植膵島の生着に重要な血流に乏しいという問題がある。
本研究では、新生血管誘導効果を持つRGD基を豊富に含有するリコンビナントペプチド(RCP)に着目し検証を行い、現在の標準法である経門脈膵島移植を大きく上回る移植効果を発揮し得ることが判明した。さらに、ADSCsを付加することでより効果的に移植前血管床構築を促進させ、移植膵島機能の改善をもたらし得ることが示唆された

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (10 results)

All 2019 2018 2017

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (6 results)

  • [Journal Article] A simple and useful predictive assay for evaluating the quality of isolated hepatocytes for hepatocyte transplantation2019

    • Author(s)
      Matsumura M, Imura T, Inagaki A, Ogasawara H, Fukuoka K , Fathi I, Miyagi S, Ohashi K, Unno M, Kamei T, Satomi S, Goto M
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 6166-6166

    • DOI

      10.1038/s41598-019-42720-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Strategy towards tailored donor tissue-specific pancreatic islet isolation2019

    • Author(s)
      Miyazaki Yuki、Murayama Kazutaka、Fathi Ibrahim、Imura Takehiro、Yamagata Youhei、Watanabe Kimiko、Maeda Hiroshi、Inagaki Akiko、Igarashi Yasuhiro、Miyagi Shigehito、Shima Hiroki、Igarashi Kazuhiko、Kamei Takashi、Unno Michiaki、Goto Masafumi
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 5 Pages: e0216136-e0216136

    • DOI

      10.1371/journal.pone.0216136

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Optimization of the Prevascularization Procedures for Improving Subcutaneous Islet Engraftment.2018

    • Author(s)
      Uematsu SS, Inagaki A, Nakamura Y, Imura T, Igarashi Y, Fathi I, Miyagi S, Ohuchi N, Satomi S, Goto M.
    • Journal Title

      Transplantation. 2018 Mar;102(3):387-395

      Volume: 102(3) Issue: 3 Pages: 387-395

    • DOI

      10.1097/tp.0000000000001970

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Optimization of Short-Term Hepatocyte Preservation Before Transplantation.2017

    • Author(s)
      Fukuoka K, Inagaki A, Nakamura Y, Matsumura M, Yoshida S, Imura T, Igarashi Y, Miyagi S, Ohashi K, Enosawa S, Kamei T, Unno M, Ohuchi N, Satomi S, Goto M.
    • Journal Title

      Transplant Direct.

      Volume: 19;3(7) Issue: 7 Pages: e176-e176

    • DOI

      10.1097/txd.0000000000000687

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 新規免疫隔離デバイスにおける膵島生着効率の検証2019

    • Author(s)
      稲垣明子、猪村武弘、Ibrahim Fathi、後藤昌史
    • Organizer
      第22回日本異種移植研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脂肪由来幹細胞を付加したリコンビナントペプチドの導入による新規皮下膵島移植方法の開発2019

    • Author(s)
      水井崇浩、稲垣明子、中村保宏、Fathi Ibrahim、猪村武弘、植松智海、宮城重人、亀井尚
    • Organizer
      第46回日本膵・膵島移植研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 免疫抑制剤不要の次世代膵島移植に向けた取り組み2019

    • Author(s)
      後藤昌史、稲垣明子、猪村武弘、Fathi Ibrahim、水井崇浩、金井哲史、戸子台一哲、、宮城 重人、村山和隆、亀井尚、海野倫明
    • Organizer
      第46回日本膵・膵島移植研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 出血が少なく使いやすい皮下デバイスを目指して:糖尿病マウスにおける RGD基含有ヒトⅠ型コラーゲン素材による皮下膵島移植についての報告2018

    • Author(s)
      植松智海、稲垣明子、中村保宏、後藤めぐみ、猪村武弘、猪村 梢、五十嵐康宏、Ibrahim Fathi、宮城重人、亀井 剛、海野倫明、里見 進、後藤昌史
    • Organizer
      第45回日本膵・膵島移植研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 免疫抑制剤を不要とする革新的膵島デバイスの開発2018

    • Author(s)
      稲垣明子、猪村梢、猪村武弘、Ibrahim Fathi、五十嵐康宏、後藤昌史
    • Organizer
      第45回日本膵・膵島移植研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 免疫抑制剤を不要とする革新的膵島デバイスの開発2017

    • Author(s)
      稲垣明子、猪村 梢、後藤めぐみ、猪村武弘、五十嵐康宏、Ibrahim Fathi、後藤昌史
    • Organizer
      第45回日本移植学会総会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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