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Establish of treatment for avoiding the graft failure in liver transplantation with steatotic small for size graft

Research Project

Project/Area Number 17K10519
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionKyoto University (2018-2019)
Kyoto Prefectural University of Medicine (2017)

Principal Investigator

IIDA TAKU  京都大学, 医学研究科, 客員研究員 (90437111)

Co-Investigator(Kenkyū-buntansha) 八木 真太郎  京都大学, 医学研究科, 講師 (60447969)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords肝移植 / 肝再生 / 脂肪肝 / 過小グラフト / marginal graft / 脂肪肝グラフト
Outline of Final Research Achievements

Steatotic liver grafts cause graft failure in liver transplantation. But so far, only the extent of fatty liver was one of the important information to judge the transplantability. The cause of fatty liver graft in the study, was analyzed for the mechanism and prognosis of each steatotic liver graft after liver transplantation. The cause of fatty liver of the donor, the effect of microcirculation disorders and oxidative stress associated with ischemic reperfusion disorders after transplantation could be shown to be different. The therapeutic effect of statins on fatty liver grafts of FHA has been suggested to be effective depending on the cause of fatty liver.

Academic Significance and Societal Importance of the Research Achievements

脂肪肝の成因によって移植後の虚血再灌流障害の病態が異なることが本研究によって明らかとなった。スタチンの血管保護作用から、微小循環障害が中心であるFHAによる脂肪肝グラフトに有効である可能性がある。本研究の学術的意義は成因毎の脂肪肝に対する移植治療戦略の構築が非常に重要であること、またICUでの絶食+高カロリー輸液管理による脳死ドナーの脂肪肝は、レシピエントの予後に大きな影響を与えると言う問題点を提示する社会的意義を持つに至った。このことから脳死ドナー候補者は出来る限り絶食などの飢餓状態とならない様に管理を行うことが肝要で、移植肝を受け入れるレシピエントの術後予後改善に寄与する事が判明した。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (28 results)

All 2020 2019 2018 2017

All Journal Article (16 results) (of which Peer Reviewed: 16 results,  Open Access: 7 results) Presentation (12 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Anatomical Pitfall in Right Posterior Sector Graft Procurement in Living Donor Liver Transplantation.2020

    • Author(s)
      Kusakabe J, Yagi S, Okamura Y, Iida T, Ogawa E, Ito T, Hata K, Taura K, Okajima H, Kaido T, Uemoto S.
    • Journal Title

      Liver Transpl.

      Volume: Feb;26(2) Issue: 2 Pages: 299-303

    • DOI

      10.1002/lt.25648

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bolus Administration of Polyamines Boosts Effects on Hepatic Ischemia-Reperfusion Injury and Regeneration in Rats2019

    • Author(s)
      Doi Junshi、Fujimoto Yasuhiro、Teratani Takumi、Kasahara Naoya、Maeda Masashi、Tsuruyama Tatsuaki、Iida Taku、Yagi Shintaro、Uemoto Shinji
    • Journal Title

      European Surgical Research

      Volume: 60 Issue: 1-2 Pages: 63-73

    • DOI

      10.1159/000497434

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Laparoscopic approach for choledochojejunostomy.2019

    • Author(s)
      Hori T, Aisu Y, Yamamoto M, Yasukawa D, Iida T, Yagi S, Taniguchi K, Uemoto S.
    • Journal Title

      Hepatobiliary Pancreat Dis Int.

      Volume: 18 Issue: 3 Pages: 285-288

    • DOI

      10.1016/j.hbpd.2019.04.004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of pretreatments on outcomes after living donor liver transplantation for hepatocellular carcinoma2019

    • Author(s)
      Ogawa Kohei、Kaido Toshimi、Okajima Hideaki、Fujimoto Yasuhiro、Yoshizawa Atsushi、Yagi Shintaro、Hori Tomohide、Iida Taku、Takada Yasutsugu、Uemoto Shinji
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: 26 Issue: 2 Pages: 73-81

    • DOI

      10.1002/jhbp.602

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Etiologies, risk factors, and outcomes of bacterial cholangitis after living donor liver transplantation.2018

    • Author(s)
      Yao S, Yagi S, Nagao M, Uozumi R, Iida T, Iwamura S, Miyachi Y, Shirai H, Kobayashi A, Okumura S, Hamaguchi Y, Masano Y, Kaido T, Okajima H, Uemoto S.
    • Journal Title

      Eur J Clin Microbiol Infect Dis.

      Volume: 10 Issue: 10 Pages: 1973-1982

    • DOI

      10.1007/s10096-018-3333-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A High Portal Venous Pressure Gradient Increases Gut-Related Bacteremia and Consequent Early Mortality After Living Donor Liver Transplantation.2018

    • Author(s)
      Yao S, Yagi S, Uozumi R, Iida T, Nagao M, Okamura Y, Anazawa T, Okajima H, Kaido T, Uemoto S.
    • Journal Title

      Transplantation.

      Volume: 4 Issue: 4 Pages: 623-631

    • DOI

      10.1097/tp.0000000000002047

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Short- and Long-Term Outcomes of Live Donor Renal Allografts From Older and Younger Donors.2018

    • Author(s)
      Matsuyama T, Ushigome H, Osaka M, Masuda K, Harada S, Nakamura T, Nobori S, Iida T, Yoshimura N.
    • Journal Title

      Transplant Proc.

      Volume: 10 Issue: 10 Pages: 3228-3231

    • DOI

      10.1016/j.transproceed.2018.08.046

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Graft Immunocomplex Capture Fluorescence Analysis to Detect Donor-Specific Antibodies and HLA Antigen Complexes in the Allograft.2017

    • Author(s)
      Nakamura T, Ushigome H, Watabe K, Imanishi Y, Masuda K, Matsuyama T, Harada S, Koshino K, Iida T, Nobori S, Yoshimura N.
    • Journal Title

      Immunol Invest.

      Volume: 3 Pages: 295-304

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful laparoscopic distal pancreatectomy for a large solid pseudopapillary neoplasm: A case report.2017

    • Author(s)
      Tada S, Iida T, Anazawa T, Yagi S, Seo S, Masui T, Kaido T, Takaori K, Uemoto S.
    • Journal Title

      Asian J Endosc Surg.

      Volume: 10 Pages: 317-320

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Short-term outcomes of laparoscopy-assisted hybrid living donor hepatectomy: a comparison with the conventional open procedure.2017

    • Author(s)
      Kitajima T, Kaido T, Iida T, Seo S, Taura K, Fujimoto Y, Ogawa K, Hatano E, Okajima H, Uemoto S.
    • Journal Title

      Surg Endosc

      Volume: 31 Issue: 12 Pages: 5101-5110

    • DOI

      10.1007/s00464-017-5575-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Liver graft preservation using perfluorocarbon improves the outcomes of simulated donation after cardiac death liver transplantation in rats.2017

    • Author(s)
      Okumura S, Uemura T, Zhao X, Masano Y, Tsuruyama T, Fujimoto Y, Iida T, Yagi S, Bezinover D, Spiess B, Kaido T, Uemoto S.
    • Journal Title

      Liver Transpl.

      Volume: 23 Issue: 9 Pages: 1171-1185

    • DOI

      10.1002/lt.24806

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significance of Proper Graft Selection in Adult Living-Donor Liver Transplant Recipients with Preoperative Deteriorated Condition.2017

    • Author(s)
      Iida T, Masuda K, Matsuyama T, Harada S, Nakamura T, Koshino K, Suzuki T, Nobori S, Ushogome H, Ito T, Sakamoto S, Uryuhara K, Okajima H, Kaihara S, Uemoto S, Yoshimura N.
    • Journal Title

      Ann Transplant.

      Volume: 22 Pages: 541-549

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk Factors and Management for Biliary Complications Following Adult Living-Donor Liver Transplantation.2017

    • Author(s)
      Nakamura T, Iida T, Ushigome H, Osaka M, Masuda K, Matsuyama T, Harada S, Nobori S, Yoshimura N.
    • Journal Title

      Ann Transplant.

      Volume: 22 Pages: 671-676

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comprehensive guide to laparoscope-assisted graft harvesting in live donors for living-donor liver transplantation: perspective of laparoscopic vision.2017

    • Author(s)
      Hori T, Kaido T, Iida T, Yagi S, Uemoto S.
    • Journal Title

      Ann Gastroenterol.

      Volume: 30 Pages: 118-126

    • DOI

      10.20524/aog.2016.0088

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of Skeletal Muscle Mass, Muscle Quality, and Visceral Adiposity on Outcomes Following Resection of Intrahepatic Cholangiocarcinoma.2017

    • Author(s)
      Okumura S, Kaido T, Hamaguchi Y, Kobayashi A, Shirai H, Fujimoto Y, Iida T, Yagi S, Taura K, Hatano E, Okajima H, Uemoto S.
    • Journal Title

      Ann Surg Oncol.

      Volume: 24 Issue: 4 Pages: 1037-1045

    • DOI

      10.1245/s10434-016-5668-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] New-onset diabetes mellitus after living-donor liver transplantation: association with graft synthetic function.2017

    • Author(s)
      Yagi S, Kaido T, Iida T, Yoshizawa A, Okajima H, Uemoto S.
    • Journal Title

      Surg Today.

      Volume: 47 Issue: 6 Pages: 733-742

    • DOI

      10.1007/s00595-016-1444-z

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 大腸癌異時性肝転移に対する肝切除術の治療成績2019

    • Author(s)
      飯田拓、岩﨑純治、原田樹幸、森彩、長田圭司、髙橋有和、松浦正徒、塩田哲也、伊丹淳、京極高久
    • Organizer
      第74回 日本消化器外科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Evaluation of clinical outcome in the pure laparoscopic liver resection, comparing with the open liver resection.2019

    • Author(s)
      飯田拓、岩﨑純治、原田樹幸、森彩、長田圭司、髙橋有和、松浦正徒、塩田哲也、伊丹淳、京極高久
    • Organizer
      日本肝胆膵外科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 当院での脳死肝移植術の治療成績とその課題2018

    • Author(s)
      飯田拓、大坂雅史、増田康史、松山剛久、原田俊平、中村緑佐、昇修治、牛込秀隆、吉村了勇
    • Organizer
      第73回 日本消化器外科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 右葉グラフトの胆管分岐異常に対して、レシピエント胆嚢管を用いて胆道再建した生体肝移植の2例2018

    • Author(s)
      松山剛久、飯田拓、大坂雅史、増田康史、原田俊平、中村緑佐、昇修治、牛込秀隆、吉村了勇
    • Organizer
      第73回 日本消化器外科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 生体肝移植を施行した肝肺症候群2例の検討2018

    • Author(s)
      増田康史、飯田拓、大坂雅史、松山剛久、原田俊平、中村緑佐、昇修治、牛込秀隆、吉村了勇
    • Organizer
      第73回 日本消化器外科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 血液透析及び腹膜透析導入患者に対してTEP法が有用であった鼠径ヘルニアの2症例2018

    • Author(s)
      原田俊平、飯田拓、大坂雅史、増田康史、松山剛久、中村緑佐、昇修治、牛込秀隆、吉村了勇
    • Organizer
      第73回 日本消化器外科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 腹腔鏡下肝切除術を施行した原発不明神経内分泌腫瘍肝転移の1例2018

    • Author(s)
      飯田 拓 、岩﨑純治、原田樹幸、森 彩、長田圭司 高橋有和、松浦正徒、塩田哲也、伊丹 淳、京極高久
    • Organizer
      第31回 日本内視鏡外科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Significance of proper graft selection on adult living donor liver transplant recipients with preoperative deteriorated condition2017

    • Author(s)
      Taku Iida, Masafumi Osaka, Koji Masuda, Takehisa Matsuyama, Shunpei Harada, Tsukasa Nakamura Shuji Nobori , Hidetaka Ushigome, Norio Yoshimura
    • Organizer
      ESOT
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] C型肝硬変に対する肝移植成績と術後抗ウイルス療法の現況2017

    • Author(s)
      飯田 拓、大坂雅史、増田康史、松山剛久、 原田俊平、中村緑佐、昇 修治、牛込秀隆、吉村了勇
    • Organizer
      第15回 日本消化器外科学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 血液型不適合肝移植の治療変遷と成績2017

    • Author(s)
      飯田 拓 、大坂雅史、増田康史、松山剛久 原田俊平、中村緑佐、昇 修治、牛込秀隆、吉村了勇
    • Organizer
      第53回 日本移植学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 生体肝移植におけるレシピエント術前状態を考慮したグラフト選択の意義2017

    • Author(s)
      飯田 拓 、大坂雅史、増田康史、松山剛久 原田俊平、中村緑佐、昇 修治、牛込秀隆、吉村了勇
    • Organizer
      第117回 日本外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 成人生体肝移植における右葉グラフト選択の意義の意義2017

    • Author(s)
      飯田 拓 、大坂雅史、増田康史、松山剛久 原田俊平、中村緑佐、昇 修治、牛込秀隆、吉村了勇
    • Organizer
      第72回日本消化器外科学会総会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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