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Critical role of TGF-beta for functional switch in cancer invasion

Research Project

Project/Area Number 17K10534
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionGunma University

Principal Investigator

FUJII TAKAAKI  群馬大学, 大学院医学系研究科, 准教授 (40507331)

Co-Investigator(Kenkyū-buntansha) 高田 考大  群馬大学, 医学部附属病院, 助教 (00781311)
矢島 玲奈  群馬大学, 医学部附属病院, 助教 (10431701)
久保 憲生  群馬大学, 医学部附属病院, 助教 (10464744)
黒住 献  群馬大学, 医学部附属病院, 助教 (40768735)
尾林 紗弥香  群馬大学, 医学部附属病院, 助教 (10648471)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords腫瘍血管新生 / 乳癌 / VEGF / PD-L1 / FDG-PET / 腫瘍免疫 / TILs / エリブリン / 炎症 / PDGF / FDG / TGF-Β / TGF-β / 癌関連線維芽細胞 / PDGF-AA / 上皮間葉移行
Outline of Final Research Achievements

VEGF effect on cancer growth and development. We demonstrated that eribulin has a potential antitumor mechanism to prevent new metastases in patients with metastatic breast cancer. VEGF expression is associated with PD-L1 and may be predictive of immunological features and biomarkers of immune checkpoint inhibitors in cases with breast cancer. Our study demonstrated that the finding of preoperative FDG uptake in breast cancer reflected the grades of TILs and the expression of PD-L1 in the primary tumor. These findings indicate that FDG uptake may be predictive of immunological features (including TILs and PD-L1 expression) in addition to aggressive features among patients with breast cancer.

Academic Significance and Societal Importance of the Research Achievements

今回の成果は、VEGFの血管新生作用に加え、腫瘍での作用、癌微小環境における役割を示すものである。特にFDG-PETやVEGF発現が腫瘍微小環境の状態を反映するとともに、免疫チェックポイント阻害剤のバイオマーカーとなりうることを示す重要なデータであると考えている。現在TGF-βと、VEGF発現、FDG集積や、TILsについて検討しており、腫瘍増殖、微小環境、免疫応答のメカニズムの本質に迫る可能性があると考えている。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (13 results)

All 2020 2019 2018 2017 2016

All Journal Article (9 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 9 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Eribulin Suppresses New Metastases in Patients With Metastatic Breast Cancer2020

    • Author(s)
      Fujii T, Tokuda S, Nakazawa Y, Kurozumi S, Obayashi S, Yajima R, Shirabe K.
    • Journal Title

      In Vivo

      Volume: 34 Issue: 2 Pages: 917-920

    • DOI

      10.21873/invivo.11858

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Relationship Between FDG Uptake and the Platelet/lymphocyte Ratio in Patients With Breast Invasive Ductal Cancer.2020

    • Author(s)
      Fujii T, Tokuda S, Nakazawa Y, Kurozumi S, Obayashi S, Yajima R, Shirabe K.
    • Journal Title

      In Vivo

      Volume: 34 Issue: 3 Pages: 1365-1369

    • DOI

      10.21873/invivo.11915

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] FDG uptake reflects breast cancer immunological features: the PD-L1 expression and degree of TILs in primary breast cancer.2020

    • Author(s)
      Hirakata T, Fujii T, Kurozumi S, Katayama A, Honda C, Yanai K, Tokuda S, Nakazawa Y, Obayashi S, Yajima R, Kaira K, Oyama T, Shirabe K.
    • Journal Title

      Breast Cancer Res Treat

      Volume: 181 Issue: 2 Pages: 331-338

    • DOI

      10.1007/s10549-020-05619-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Relationship Between FDG Uptake and Neutrophil/Lymphocyte Ratio in Patients with Invasive Ductal Breast Cancer.2018

    • Author(s)
      Fujii T, Yanai K, Tokuda S, Nakazawa Y, Kurozumi S, Obayashi S, Yajima R, Hirakata T, Shirabe K
    • Journal Title

      Anticancer Res

      Volume: 38 Issue: 8 Pages: 4927-4931

    • DOI

      10.21873/anticanres.12809

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Phase II Study of S-1 plus Trastuzumab for HER2-positive Metastatic Breast Cancer (GBCCSG-01).2018

    • Author(s)
      Fujii T, Horiguchi J, Yanagita Y, Koibuchi Y, Ikeda F, Uchida N, Kimura M
    • Journal Title

      Anticancer Res

      Volume: 38 Pages: 905-909

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Implication of atypical supraclavicular F18-fluorodeoxyglucose uptake in patients with breast cancer: Association between brown adipose tissue and breast cancer.2017

    • Author(s)
      Fujii T, Yajima R, Tatsuki H, Oosone K, Kuwano H.
    • Journal Title

      Oncology Letter

      Volume: 14 Pages: 7025-7030

    • DOI

      10.3892/ol.2017.6768

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinicopathological Features of Ductal Carcinoma In Situ from 18F-FDG-PET Findings.2017

    • Author(s)
      Fujii T, Yanai K, Tokuda S, Nakazawa Y, Kurozumi S, Obayashi S, Yajima R, Hirakata T, Kuwano H.
    • Journal Title

      Anticancer Research

      Volume: 37 Pages: 5053-5056

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 18F-fluorodeoxyglucose uptake as predictor for invasion in preoperatively diagnosed breast ductal carcinoma in situ: Significance in cases without mass formation.2017

    • Author(s)
      Fujii T, Yajima R, Tatsuki H, Kuwano H.
    • Journal Title

      Molecular Clinical Oncology

      Volume: 7 Pages: 183-187

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Anticancer effect of rapamycin on MCF-7 via downregulation of VEGF expression.2016

    • Author(s)
      Fujii T, Yajima R, Tatsuki H, Oosone K, Kuwano H.
    • Journal Title

      In Vitro Cell Dev Biol Anim.

      Volume: 52 Issue: 1 Pages: 45-48

    • DOI

      10.1007/s11626-015-9944-5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 乳癌におけるFDG集積と炎症, 免疫の関連:NLRとTILsから見たFDG集積2019

    • Author(s)
      藤井孝明、 黒住献、片山彩香、小山徹也、矢内恵子、徳田尚子、中澤祐子、尾林紗弥香、矢島玲奈、平方智子
    • Organizer
      第119回日本外科学会定期学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 乳癌におけるVEGF発現とPD-L1発現の関連2019

    • Author(s)
      西木瑛理子、平方智子、徳田尚子、中澤祐子、黒住献、尾林紗弥香、矢島玲奈、片山彩香、小山轍也、藤井孝明
    • Organizer
      第28回乳癌基礎研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Implication of atypical supraclavicular F18-fluorodeoxyglucose uptake in patients with breast cancer: Relationship between brown adipose tissue and TILs, PD-L12019

    • Author(s)
      TAKAAKI FUJII, SHOKO TOKUDA, YUKO NAKAZAWA, SASAGU KUROZUMI, SAYAKA OBAYASHI, REINA YAJIMA, TOMOKO HIRAKATA, KEN SHIRABE
    • Organizer
      第59回日本癌治療学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Relationship between FDG-uptake and neutrophil/lymphocyte ratio in patients with primary breast cancer2018

    • Author(s)
      TAKAAKI FUJII, KEIKO YANAI, NAOKO TOKUDA, YUKO NAKAZAWA, SASAGU KUROZUMI, SAYAKA OBAYASHI, REINA YAJIMA, TOMOKO HIRAKATA, KEN SHIRABE
    • Organizer
      SAN ANTONIO BREAST CANCER SYMPOSIUM
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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