Development of immunotherapy with T cells in breast cancer
| Project/Area Number |
17K10540
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Mimura Kosaku 福島県立医科大学, 医学部, 准教授 (90568031)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 乳癌 / 癌微小環境 / phospho-STAT1 / PD-L1 / HLA class I / CD8陽性T細胞 / 乳がん / 乳腺外科学 / 免疫細胞療法 |
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| Outline of Final Research Achievements |
In the present study, we indicated that PD-L1 and HLA class I were co-expressed in phospho-STAT1, a molecule in the IFN-γ signaling pathway, positive breast cancer cells, and that phospho-STAT1 in breast cancer cells was activated by IFN-γ secreted from tumor infiltrating immune cells, and that phospho-STAT1 expression in breast cancer cells may be a potential biomarker for immunotherapy with anti-PD-1 monoclonal antibody.
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| Academic Significance and Societal Importance of the Research Achievements |
近年、進行乳癌に対する新たな治療戦略の1つとして抗PD-1抗体を用いた免疫細胞療法が施行されている。しかし、その臨床効果は限られており、更なる治療の開発やバイオマーカーの開発などが必要と考えられている。乳癌微小環境におけるPD-L1の発現機構の１つを解明した本申請研究の成果は、進行乳癌症例おいて、抗PD-1抗体を用いた免疫細胞療法の効果増強方法やバイオマーカーの開発に寄与するものである。
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Phospho-STAT1 expression as a potential biomarker for ant-PD-1/anti-PD-L1 immunotherapy for breast cancer.2019
Author(s)
Nakayama Y, Mimura K, Tamaki T, Shiraishi K, Kua LF, Koh V, Ohmori M, Kimura A, Inoue S, Okayama H, Suzuki Y, Nakazawa T, Ichikawa D, Kono K.
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Journal Title
Int J Oncol.
Volume: 54
Pages: 2030-2038
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Immunotherapy for esophageal squamous cell carcinoma: a review2018
Author(s)
Mimura K, Yamada L, Ujiie D, Hayase S, Tada T, Hanayama H, Thar Min AK, Shibata M, Momma T, Saze Z, Ohki S, Kono K.
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Journal Title
FUKUSHIMA JOURNAL OF MEDICAL SCIENCE
Volume: 64
Issue: 2
Pages: 46-53
DOI
NAID
ISSN
0016-2590, 2185-4610
Related Report
Peer Reviewed
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[Presentation] 乳癌微小環境におけるPD-L1の発現機構2018
Author(s)
中山 裕子,三村 耕作,中澤 匡男,白石謙介,井上 正行,門馬智之,佐瀬善一郎,大木進司,井上 慎吾,市川大輔,河野 浩二
Organizer
第31回日本バイオセラピィ学会学術集会総会
Related Report
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