Expression and role of TRPV2 in esophageal squamous cell carcinoma and cancer stem cells.

• Project/Area Number: 17K10602
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Shiozaki Atsushi 京都府立医科大学, 医学(系)研究科(研究院), 助教 (40568086)
• Co-Investigator(Kenkyū-buntansha): 大辻 英吾 京都府立医科大学, 医学(系)研究科(研究院), 教授 (20244600)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 食道癌 / 食道外科学 / 癌幹細胞 / イオンチャネル

Outline of Final Research Achievements

Cells exhibiting strong ALDH1A1 activity were isolated from TE4 and TE8 esophageal squamous cell carcinoma (ESCC) cells by cell sorting, and cancer stem cells (CSCs) were generated with the sphere formation assay. Microarray analysis revealed TRPV2 was upregulated in CSCs, and its inhibitor tranilast effectively decreased the number of tumorspheres. An immunohistochemical analysis revealed a relationship between strong TRPV2 expression and a poor prognosis in ESCC patients. TRPV2 was overexpressed in TE15 and KYSE170 cells, and TRPV2 depletion with siRNA suppressed cell proliferation, cell cycle progression, and invasion/migration, and induced apoptosis. A pathway analysis of microarray data revealed that TRPV2 depletion down-regulated WNT/β-catenin signaling-related genes. These results provide an insight into the role of TRPV2 as a biomarker, and that its specific inhibitor, tranilast, has potential as a targeted therapeutic agent against ESCC.

Academic Significance and Societal Importance of the Research Achievements

TRPV2が食道扁平上皮癌幹細胞において高発現し、その阻害剤であるトラニラストが癌幹細胞特異的に抑制効果を示すことを新たに見出した。トラニラストは抗アレルギー剤、ケロイド・肥厚性瘢痕の予防・治療薬として臨床で用いられている薬剤であり、その抗腫瘍効果を明らかにしたことの社会的意義は大きいと考えられる。また、TRPV2のWnt/β-カテニンシグナル伝達系を介する新たな腫瘍進展制御機構や、予後因子としての意義を明らかにし、バイオマーカーや治療標的としての可能性を示した。

Research Products

• [Journal Article] ANO9 Regulated Cell Cycle in Human Esophageal Squamous Cell Carcinoma. (2020)
  • Author(s): Katsurahara K, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.
  • Journal Title: Ann Surg Oncol. Volume: ー Issue: 9 Pages: 3218-3230
  • DOI: 10.1245/s10434-020-08368-y
  • Peer Reviewed
• [Journal Article] Involvement of Intracellular and Extracellular High-Mobility Group Box-1 in the Progression of Esophageal Squamous Cell Carcinoma. (2020)
  • Author(s): Matsubara D, Konishi H, Arita T, Shoda K, Fujita Y, Ogino S, Takao K, Nanishi K, Kosuga T, Komatsu S, Shiozaki A, Fujiwara H, Okamoto K, Otsuji E.
  • Journal Title: Ann Surg Oncol. Volume: ー Issue: 9 Pages: 3233-3244
  • DOI: 10.1245/s10434-020-08363-3
  • Peer Reviewed
• [Journal Article] Plasma microRNA profiles: identification of miR-1229-3p as a novel chemoresistant and prognostic biomarker in gastric cancer (2020)
  • Author(s): Nishibeppu K, Komatsu S et al.
  • Journal Title: Sci Rep Volume: 10 Issue: 1 Pages: 3161-3161
  • DOI: 10.1038/s41598-020-59939-8
  • Peer Reviewed / Open Access
• [Journal Article] The expression and role of TRPV2 in esophageal squamous cell carcinoma. (2019)
  • Author(s): Kudou M, Shiozaki A, Yamazato Y, Katsurahara K, Kosuga T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 16055-16055
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  • Peer Reviewed / Open Access
• [Journal Article] Effect of low temperature on the regulation of cell volume after hypotonic shock in gastric cancer cells. (2019)
  • Author(s): Shiozaki A, Yamazato Y, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E.
  • Journal Title: Int J Oncol. Volume: 55 Pages: 905-914
  • DOI: 10.3892/ijo.2019.4853
  • Peer Reviewed
• [Journal Article] LRRC8A Expression Influences Growth of Esophageal Squamous Cell Carcinoma. (2019)
  • Author(s): Konishi T, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.
  • Journal Title: Am J Pathol. Volume: 189 Issue: 10 Pages: 1973-1985
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  • Peer Reviewed
• [Journal Article] Value of Prognostic Nutritional Index as a Predictor of Lymph Node Metastasis in Gastric Cancer (2019)
  • Author(s): KOSUGA TOSHIYUKI、KONISHI TOMOKI、KUBOTA TAKESHI、SHODA KATSUTOSHI、KONISHI HIROTAKA、SHIOZAKI ATSUSHI、OKAMOTO KAZUMA、FUJIWARA HITOSHI、KUDOU MICHIHIRO、ARITA TOMOHIRO、MORIMURA RYO、MURAYAMA YASUTOSHI、KURIU YOSHIAKI、IKOMA HISASHI、NAKANISHI MASAYOSHI、OTSUJI EIGO
  • Journal Title: Anticancer Research Volume: 39 Issue: 12 Pages: 6843-6849
  • DOI: 10.21873/anticanres.13901
  • Peer Reviewed
• [Journal Article] Clinical significance of neutrophil-to-lymphocyte ratio as a predictor of lymph node metastasis in gastric cancer (2019)
  • Author(s): Kosuga Toshiyuki、Konishi Tomoki、Kubota Takeshi、Shoda Katsutoshi、Konishi Hirotaka、Shiozaki Atsushi、Okamoto Kazuma、Fujiwara Hitoshi、Kudou Michihiro、Arita Tomohiro、Morimura Ryo、Murayama Yasutoshi、Kuriu Yoshiaki、Ikoma Hisashi、Nakanishi Masayoshi、Otsuji Eigo
  • Journal Title: BMC Cancer Volume: 19 Issue: 1 Pages: 1187-1187
  • DOI: 10.1186/s12885-019-6404-8
  • Peer Reviewed / Open Access
• [Journal Article] Functional Outcomes of Billroth I Gastroduodenostomy Using Linear Staplers in Totally Laparoscopic Distal Gastrectomy. (2019)
  • Author(s): Katsurahara K, Kosuga T, Kubota T, Shiozaki A, Okamoto K, Shoda K, Konishi H, Fujiwara H, Kudou M, Arita T, Morimura R, Murayama Y, Kuriu Y, Ikoma H, Nakanishi M, Komatsu S, Otsuji E.
  • Journal Title: In Vivo. Volume: 33 Issue: 6 Pages: 1993-1999
  • DOI: 10.21873/invivo.11695
  • Peer Reviewed / Open Access
• [Journal Article] Overexpression of CTEN relates to tumor malignant potential and poor outcomes of adenocarcinoma of the esophagogastric junction. (2019)
  • Author(s): Aratani K, Komatsu S, Ichikawa D, Ohashi T, Miyamae M, Okajima W, Imamura T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E.
  • Journal Title: Oncotarget. Volume: 10 Issue: 55 Pages: 5726-5726
  • DOI: 10.18632/oncotarget.27229
  • Peer Reviewed / Open Access
• [Journal Article] Transmediastinal approach for esophageal cancer: A new trend toward radical surgery (2019)
  • Author(s): Fujiwara Hitoshi、Shiozaki Atsushi、Konishi Hirotaka、Otsuji Eigo
  • Journal Title: Asian Journal of Endoscopic Surgery Volume: 12 Issue: 1 Pages: 30-36
  • DOI: 10.1111/ases.12687
  • Peer Reviewed / Open Access
• [Journal Article] Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer (2018)
  • Author(s): Shiozaki Atsushi、Ariyoshi Yosuke、Iitaka Daisuke、Kosuga Toshiyuki、Shimizu Hiroki、Kudou Michihiro、Konishi Tomoki、Shoda Katsutoshi、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Marunaka Yoshinori、Ichikawa Daisuke、Otsuji Eigo
  • Journal Title: Gastric Cancer Volume: 22 Issue: 3 Pages: 473-485
  • DOI: 10.1007/s10120-018-0874-2
  • NAID: 40021884050
  • Peer Reviewed
• [Journal Article] Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma (2018)
  • Author(s): Shiozaki A, Hikami S, Ichikawa D, Kosuga T, Shimizu H, Kudou M, Yamazato Y, Kobayashi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E
  • Journal Title: Oncotarget Volume: 9 Issue: 40 Pages: 25993-26006
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  • Peer Reviewed / Open Access
• [Journal Article] Aquaporin 1 suppresses apoptosis and affects prognosis in esophageal squamous cell carcinoma (2018)
  • Author(s): Yamazato Yuzo、Shiozaki Atsushi、Ichikawa Daisuke、Kosuga Toshiyuki、Shoda Katsutoshi、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Marunaka Yoshinori、Otsuji Eigo
  • Journal Title: Oncotarget Volume: 9 Issue: 52 Pages: 29957-29974
  • DOI: 10.18632/oncotarget.25722
  • Peer Reviewed / Open Access
• [Journal Article] Chloride intracellular channel 1 as a switch among tumor behaviors in human esophageal squamous cell carcinoma (2018)
  • Author(s): Kobayashi Toshiyuki、Shiozaki Atsushi、Nako Yoshito、Ichikawa Daisuke、Kosuga Toshiyuki、Shoda Katsutoshi、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Marunaka Yoshinori、Otsuji Eigo
  • Journal Title: Oncotarget Volume: 9 Issue: 33 Pages: 23237-23252
  • DOI: 10.18632/oncotarget.25296
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Feeding Jejunostomy via Gastric Tube Versus Jejunum After Esophageal Cancer Surgery (2018)
  • Author(s): KONISHI TOMOKI、SHIOZAKI ATSUSHI、FUJIWARA HITOSHI、KONISHI HIROTAKA、TAKEMOTO KENICHI、KUDOU MICHIHIRO、SHODA KATSUTOSHI、ARITA TOMOHIRO、KOSUGA TOSHIYUKI、MORIMURA RYO、MURAYAMA YASUTOSHI、KURIU YOSHIAKI、IKOMA HISASHI、KUBOTA TAKESHI、NAKANISHI MASAYOSHI、OKAMOTO KAZUMA、OTSUJI EIGO
  • Journal Title: Anticancer Research Volume: 38 Issue: 8 Pages: 4941-4945
  • DOI: 10.21873/anticanres.12811
  • Peer Reviewed
• [Journal Article] Relationship Between Postoperative CRP and Prognosis in Thoracic Esophageal Squamous Cell Carcinoma (2018)
  • Author(s): KATSURAHARA KEITA、SHIOZAKI ATSUSHI、FUJIWARA HITOSHI、KONISHI HIROTAKA、KUDOU MICHIHIRO、SHODA KATSUTOSHI、ARITA TOMOHIRO、KOSUGA TOSHIYUKI、MORIMURA RYO、MURAYAMA YASUTOSHI、KURIU YOSHIAKI、IKOMA HISASHI、KUBOTA TAKESHI、NAKANISHI MASAYOSHI、OKAMOTO KAZUMA、OTSUJI EIGO
  • Journal Title: Anticancer Research Volume: 38 Issue: 11 Pages: 6513-6518
  • DOI: 10.21873/anticanres.13016
  • Peer Reviewed
• [Journal Article] Glutathione S‐transferase Pi 1 is a valuable predictor for cancer drug resistance in esophageal squamous cell carcinoma (2018)
  • Author(s): Ogino Shinpei、Konishi Hirotaka、Ichikawa Daisuke、Matsubara Daiki、Shoda Katsutoshi、Arita Tomohiro、Kosuga Toshiyuki、Komatsu Shuhei、Shiozaki Atsushi、Okamoto Kazuma、Kishimoto Mitsuo、Otsuji Eigo
  • Journal Title: Cancer Science Volume: 110 Issue: 2 Pages: 795-804
  • DOI: 10.1111/cas.13896
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• [Journal Article] Value of Preoperative PET-CT in the Prediction of Pathological Stage of Gastric Cancer (2018)
  • Author(s): Kudou Michihiro、Kosuga Toshiyuki、Kubota Takeshi、Okamoto Kazuma、Komatsu Shuhei、Shoda Katsutoshi、Konishi Hirotaka、Shiozaki Atsushi、Fujiwara Hitoshi、Arita Tomohiro、Morimura Ryo、Murayama Yasutoshi、Kuriu Yoshiaki、Ikoma Hisashi、Nakanishi Masayoshi、Otsuji Eigo
  • Journal Title: Annals of Surgical Oncology Volume: 25 Issue: 6 Pages: 1633-1639
  • DOI: 10.1245/s10434-018-6455-0
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• [Journal Article] Detection of fusion gene in cell-free DNA of a gastric synovial sarcoma. (2018)
  • Author(s): Ogino S, Konishi H, Ichikawa D, Hamada J, Shoda K, Arita T, Komatsu S, Shiozaki A, Okamoto K, Yamazaki S, Yasukawa S, Konishi E, Otsuji E.
  • Journal Title: World J Gastroenterol. Volume: 24 Issue: 8 Pages: 949-956
  • DOI: 10.3748/wjg.v24.i8.949
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• [Journal Article] Esophageal cancer stem cells are suppressed by tranilast, a TRPV2 channel inhibitor. (2017)
  • Author(s): Shiozaki A, Kudou M, Ichikawa D, Fujiwara H, Shimizu H, Ishimoto T, Arita T, Kosuga T, Konishi H, Komatsu S, Okamoto K, Marunaka Y, Otsuji E.
  • Journal Title: J Gastroenterol Volume: 印刷中 Issue: 2 Pages: 197-207
  • DOI: 10.1007/s00535-017-1338-x
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• [Journal Article] Expression and role of anion exchanger 1 in esophageal squamous cell carcinoma. (2017)
  • Author(s): Shiozaki A, Kudou M, Ichikawa D, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E.
  • Journal Title: Oncotarget Volume: 8 Issue: 11 Pages: 17921-17935
  • DOI: 10.18632/oncotarget.14900
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• [Journal Article] Regulation of osmolality for cancer treatment. (2017)
  • Author(s): Shiozaki A, Ichikawa D, Kosuga T, Marunaka Y, Otsuji E.
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• [Journal Article] Na+/H+ exchanger 1 has tumor suppressive activity and prognostic value in esophageal squamous cell carcinoma. (2017)
  • Author(s): Ariyoshi Y, Shiozaki A, Ichikawa D, Shimizu H, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E.
  • Journal Title: Oncotarget Volume: 10 Issue: 2 Pages: 2209-2223
  • DOI: 10.18632/oncotarget.13645
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• [Journal Article] Blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer (2017)
  • Author(s): Kosuga Toshiyuki、Shiozaki Atsushi、Kudou Michihiro、Yamazato Yuzo、Ichikawa Daisuke、Komatsu Shuhei、Konishi Hirotaka、Okamoto Kazuma、Shoda Katsutoshi、Arita Tomohiro、Morimura Ryo、Murayama Yasutoshi、Kuriu Yoshiaki、Ikoma Hisashi、Nakanishi Masayoshi、Fujiwara Hitoshi、Marunaka Yoshinori、Otsuji Eigo
  • Journal Title: Oncotarget Volume: 8 Issue: 60 Pages: 101394-101405
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• [Journal Article] Heat shock exerts anticancer effects on liver cancer via autophagic degradation of aquaporin 5. (2017)
  • Author(s): Kudou M, Shiozaki A, Kosuga T, Shimizu H, Ichikawa D, Konishi H, Morimura R, Komatsu S, Ikoma H, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E.
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• [Journal Article] Transient Receptor Potential Melastatin 7 as an Independent Prognostic Factor in Human Esophageal Squamous Cell Carcinoma. (2017)
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• [Journal Article] The Role of cIAP1 and XIAP in Apoptosis Induced by Tumor Necrosis Factor Alpha in Esophageal Squamous Cell Carcinoma Cells. (2017)
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• [Journal Article] Hand-assisted technique beneficial for laparoscopic transhiatal esophagectomy with en-bloc dissection of middle and lower mediastinal lymph nodes: roles of the operator’s left hand (2017)
  • Author(s): Shiozaki Atsushi、Fujiwara Hitoshi、Konishi Hirotaka、Arita Tomohiro、Kosuga Toshiyuki、Morimura Ryo、Murayama Yasutoshi、Komatsu Shuhei、Kuriu Yoshiaki、Ikoma Hisashi、Nakanishi Masayoshi、Ichikawa Daisuke、Okamoto Kazuma、Otsuji Eigo
  • Journal Title: Esophagus Volume: 14 Issue: 2 Pages: 138-145
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  • NAID: 40021166210
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• [Journal Article] Efficacy of Additional Surgical Resection After Endoscopic Submucosal Dissection for Superficial Esophageal Cancer. (2017)
  • Author(s): Kudou M, Shiozaki A, Fujiwara H, Konishi H, Shoda K, Arita T, Kosuga T, Morimura R, Murayama Y, Kuriu Y, Ikoma H, Kubota T, Nakanishi M, Okamoto K, Dohi O, Konishi H, Naito Y, Otsuji E.
  • Journal Title: Anticancer Res. Volume: 37 Pages: 5301-5307
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• [Journal Article] Short- and Long-term Progress of Recurrent Laryngeal Nerve Paralysis After Subtotal Esophagectomy. (2017)
  • Author(s): Shimizu H, Shiozaki A, Fujiwara H, Konishi H, Kosuga T, Komatsu S, Ichikawa D, Okamoto K, Otsuji E.
  • Journal Title: Anticancer Res. Volume: 37 Pages: 2019-2023
  • Peer Reviewed
• [Presentation] 食道扁平上皮癌におけるTRPV2発現の臨床病理学的意義についての検討 (2019)
  • Author(s): 加藤俊治、塩﨑敦、山里有三、小菅敏幸、小西博貴、窪田健、藤原斉、岡本和真、岸本光夫、森村玲、生駒久視、村山康利、栗生宜明、中西正芳、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 膵癌幹細胞における4-aminopyridineの抗腫瘍効果について (2019)
  • Author(s): 小西智規、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 食道癌におけるLeucine-Rich Repeat-Containing protein 8A（LRRC8A）発現と機能解析 (2019)
  • Author(s): 倉島研人、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるAno9発現の意義 (2019)
  • Author(s): 葛原啓太、塩﨑敦、工藤道弘、庄田勝俊、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] ヒト食道扁平上皮癌におけるNa+/K+-ATPase発現と役割 (2019)
  • Author(s): 小林利行、塩﨑敦、工藤道弘、小菅敏幸、庄田勝俊、有田智洋、小西博貴、小松周平、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、小西英一、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるCLC-2（Chloride Channel protein 2）発現の意義 (2019)
  • Author(s): 満田雅人、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるCFTR（cystic fibrosis transmembrane conductance regulator）の発現の意義 (2019)
  • Author(s): 松本順久、塩﨑敦、工藤道弘、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 胃癌細胞の低浸透圧処理後容積変化における低温刺激の影響 (2019)
  • Author(s): 中村慶、塩﨑敦、小菅敏幸、山里有三、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾.
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 低浸透圧による細胞容積制御を介した胃癌細胞へのパクリタキセル取り込み増強効果 (2019)
  • Author(s): 小菅敏幸、塩﨑敦、工藤道弘、飯高大介、小林利行、竹本健一、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、岡本和真、藤原斉、小松周平、市川大輔、大辻英吾.
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] High CD44 gastric cancer stem cells are suppressed by voltage gated Ca2+ channel blocker. (2019)
  • Author(s): Keita Katsurahara, Atsushi Shiozaki, Michihiro Kudou, Katsutoshi Shoda, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Ryo Morimura, Yasutoshi Murayama, Takeshi Kubota, Masayoshi Nakanishi, Hitoshi Fujiwara, Eigo Otsuji.
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] The development of novel targeted therapies to over-expressed ion transporters in esophageal cancer stem cells. (2019)
  • Author(s): Yoshihisa Matsumoto, Michihiro Kudou, Atsushi Shiozaki, Toshiyuki Kosuga, Ryo Morimura , Yasutoshi Murayama, Yoshiaki Kuriu , Hisashi Ikoma, Takeshi Kubota, Masayoshi Nakanishi, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji.
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] 胃癌におけるヨウ化ナトリウム共輸送体のIFNシグナルを介する腫瘍制御機構の解明 (2019)
  • Author(s): 塩﨑敦、有吉要輔、小菅敏幸、工藤道弘、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第57回日本癌治療学会学術集会
• [Presentation] 食道癌幹細胞特異的に発現するion channelの同定と新規標的治療への応用 (2018)
  • Author(s): 塩﨑敦, 工藤道弘, 藤原斉, 小西博貴, 庄田勝俊, 有田智洋, 小菅敏幸, 森村玲, 村山康利, 栗生宜明, 生駒久視, 窪田健, 中西正芳, 岡本和真, 大辻英吾
  • Organizer: JDDW2018（第16回日本消化器外科学会大会）
• [Presentation] 食道扁平上皮癌におけるAnion exchanger 2の細胞遊走能制御機構の解明 (2018)
  • Author(s): 塩﨑敦、樋上翔一郎、小菅敏幸、工藤道弘、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第56回日本癌治療学会学術集会
• [Presentation] 食道癌幹細胞に高発現する TRPV2 を標的とした新たな治療方法の開発 (2018)
  • Author(s): 葛原啓太、塩﨑敦、工藤道弘、庄田勝俊、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌における Na+/K+-ATPase の発現意義 (2018)
  • Author(s): 松本順久、塩﨑敦、小林利行、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌における Aquaporin 1 の発現機能 (2018)
  • Author(s): 山里有三、塩﨑敦、庄田勝俊、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌における CLIC1 の発現意義と機能解析 (2018)
  • Author(s): 小林利行、塩﨑敦、名幸義人、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 食道癌における Leucine-Rich Repeat-Containing protein 8A（LRRC8A）発現の臨床的意義について (2018)
  • Author(s): 小西智規、塩﨑敦、工藤道弘、庄田勝俊、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 胃癌細胞における低温刺激がもたらすRegulatory Volume Decrease (RVD) への影響． (2018)
  • Author(s): 満田雅人、塩﨑敦、山里有三、小菅敏幸、庄田勝俊、小西博貴、窪田健、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] Functional analysis and prognostic value of sodium iodide symporter (NIS) in gastric cancer (2018)
  • Author(s): Atsushi Shiozaki, Yosuke Ariyoshi, Toshiyuki Kosuga, Michihiro Kudou, Katsutoshi Shoda, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Yoshinori Marunaka, Eigo Otsuji
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] 胃癌におけるsodium iodide symporter(NIS)の機能とその臨床病理学的意義． (2017)
  • Author(s): 有吉要輔、塩﨑敦、市川大輔、有田智洋、小菅敏幸、小西博貴、森村玲、小松周平、生駒久視、栗生宜明、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾．
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 肝癌における温熱刺激によるAquaporin5制御を介した抗腫瘍効果． (2017)
  • Author(s): 小菅敏幸、塩﨑敦、工藤道弘、清水浩紀、市川大輔、小松周平、小西博貴、有田智洋、森村玲、村山康利、栗生宜明、生駒久視、中西正芳、岡本和真、藤原斉、大辻英吾．
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 食道癌におけるanion exchanger 1(AE1)の発現と役割． (2017)
  • Author(s): 小西智規、塩﨑敦、工藤道弘、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、小松周平、栗生宜明、生駒久視、中西正芳、市川大輔、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるCLIC1（Chloride Intracellular Channel-1）発現の意義． (2017)
  • Author(s): 小林利行、塩﨑敦、市川大輔、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、小松周平、栗生宜明、生駒久視、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾．
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるAquaporin1発現の臨床病理学的意義． (2017)
  • Author(s): 山里有三、塩﨑敦、市川大輔、小西智規、小林利行、有吉要輔、樋上翔一郎、工藤道弘、庄田勝俊、有田智洋、小西博貴、小菅敏幸、森村玲、村山康利、小松周平、栗生宜明、生駒久視、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるAnion Exchanger 2の発現・機能解析 (2017)
  • Author(s): 塩﨑敦、樋上翔一郎、小菅敏幸、庄田勝俊、有田智洋、小西博貴、小松周平、窪田健、藤原斉、岡本和真、岸本光夫、丸中良典、大辻英吾．
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 食道癌におけるsodium iodide symporterの発現とその意義 (2017)
  • Author(s): 有吉要輔、塩﨑敦、市川大輔、飯高大介、小菅敏幸、小西博貴、窪田健、藤原斉、岡本和真、岸本光夫、丸中良典、大辻英吾．
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 食道扁平上皮癌におけるCLIC1(Chloride Intracellular Channel-1)の発現と役割 (2017)
  • Author(s): 小林利行、塩﨑敦、小菅敏幸、名幸義人、工藤道弘、庄田勝俊、有田智洋、小西博貴、窪田健、藤原斉、岡本和真、岸本光夫、大辻英吾．
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 胃癌におけるNISの発現と機能 (2017)
  • Author(s): 小西智規、塩﨑敦、有吉要輔、飯高大輔、小菅敏幸、小西博貴、窪田健、藤原斉、岡本和真、岸本光夫、丸中良典、大辻英吾．
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 食道癌幹細胞のイオン輸送体を標的とした治療法の開発 (2017)
  • Author(s): 工藤道弘、塩﨑敦、小菅敏幸、有田智洋、庄田勝俊、中西正芳、栗生宜明、窪田健、中西正芳、藤原斉、岡本和真、丸中良典、大辻英吾．
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 食道扁平上皮癌におけるAquaporin1の発現と予後との検討 (2017)
  • Author(s): 山里有三、塩﨑敦、有田智洋、小菅敏幸、小西博貴、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾．
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 胃癌におけるカリウムイオン輸送遮断による低浸透圧殺細胞増強効果 (2017)
  • Author(s): 小菅敏幸、塩﨑敦、工藤道弘、山里有三、小松周平、小西博貴、有田智洋、村山康利、窪田健、岡本和真、藤原斉、中西正芳、大辻英吾．
  • Organizer: 第76回日本癌学会学術総会