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Circulating tumor DNA monitoring in esophageal squamous cell carcinoma patients

Research Project

Project/Area Number 17K10605
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionIwate Medical University

Principal Investigator

Takeshi Iwaya  岩手医科大学, 医学部, 特任准教授 (70405801)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords食道癌 / circulating tumor DNA / 変異 / デジタルPCR / 血漿DNA / Circulating tumor DNA / 癌 / ゲノム / トランスレーショナルリサーチ
Outline of Final Research Achievements

Esophageal squamous cell carcinoma (ESCC) is a poor prognosis tumor. Analysis of circulating tumor DNA (ctDNA) has demonstrated promising results for cancer diagnosis. However, ctDNA test hasn’t yet been an established tool in daily practice of cancer patients. This study aimed to investigate whether frequent tumor burden monitoring with ctDNA of individual tumor-specific mutations using digital PCR (dPCR) provides clinically useful information for ESCC patients. Mutation screening of primary ESCCs was performed with amplicon sequencing using originally-designed SCC panel, targeting 31 genes. The level of ctDNAs were evaluated using dPCR with originally-designed primer/probe sets for individual mutations. 27). This study demonstrated clinical validities of tumor burden monitoring with patient-specific ctDNA using dPCR in standard-of-care for ESCC patients including: 1) relapse and growth prediction, 2) treatment efficacy evaluation, and 3) relapse-free confirmation.

Academic Significance and Societal Importance of the Research Achievements

次世代シークエンサー (NGS)を用いたctDNA解析は、組織採取困難な症例の癌診断や薬剤の投薬根拠となる変異の検出などいわゆるLiquid biopsyに適した方法である。しかし、治療期間での頻回な検査や長期間のfollow upなど広く多数の癌患者で行うことは、コストや解析時間を要する。また微量なctDNAはいずれの手法を用いても、偽陽性・偽陰性は完全に避けられないため、異なる手法による検証も必要である。治療法決定に多くの情報が必要な場合のNGS解析と治療効果の頻回な判定、長期間の再発モニタリングにはdigital PCRと合わせた効率的システムを確立した。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (23 results)

All 2020 2019 2018 2017

All Journal Article (9 results) (of which Open Access: 7 results,  Peer Reviewed: 8 results) Presentation (12 results) (of which Int'l Joint Research: 4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Frequent tumor burden monitoring of esophageal squamous cell carcinoma with circulating tumor DNA using individually designed digital PCR2020

    • Author(s)
      Iwaya Takeshi、Endo Fumitaka、Yaegashi Mizunori、Sasaki Noriyuki、Fujisawa Ryosuke、Hiraki Hayato、Akiyama Yuji、Sasaki Akira、Suzuki Yuji、Masuda Mari、Yamada Tesshi、Takahashi Fumiaki、Tokino Takashi、Sasaki Yasushi、Nishizuka Satoshi S
    • Journal Title

      medRxiv

      Volume: NA

    • DOI

      10.1101/2020.05.01.20087106

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] Safety of thoracoscopic esophagectomy after induction chemotherapy for locally advanced unresectable esophageal squamous cell carcinoma2020

    • Author(s)
      Akiyama Yuji、Iwaya Takeshi、Endo Fumitaka、Nikai Haruka、Baba Shigeaki、Chiba Takehiro、Kimura Toshimoto、Takahara Takeshi、Otsuka Koki、Nitta Hiroyuki、Mizuno Masaru、Kimura Yusuke、Koeda Keisuke、Sasaki Akira
    • Journal Title

      Asian Journal of Endoscopic Surgery

      Volume: 13 Issue: 2 Pages: 152-159

    • DOI

      10.1111/ases.12731

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recurrence risk evaluation in T1N1M0/T2N0M0/T3N0M0 gastric cancer with TP53 codon 72 polyphorphism2019

    • Author(s)
      Omori Y, Nomura T, Fukushima N, Takahashi F, Iwaya T, Koeda K, Nishizuka SS
    • Journal Title

      J Surg Oncol

      Volume: 120 Issue: 7 Pages: 1154-1161

    • DOI

      10.1002/jso.25718

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the need for routine feeding jejunostomy for enteral nutrition after esophagectomy2018

    • Author(s)
      Akiyama Yuji、Iwaya Takeshi、Endo Fumitaka、Nikai Haruka、Sato Kei、Baba Shigeaki、Chiba Takehiro、Kimura Toshimoto、Takahara Takeshi、Nitta Hiroyuki、Otsuka Koki、Mizuno Masaru、Kimura Yusuke、Koeda Keisuke、Sasaki Akira
    • Journal Title

      Journal of Thoracic Disease

      Volume: 10 Issue: 12 Pages: 6854-6862

    • DOI

      10.21037/jtd.2018.11.97

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Giant gastrointestinal stromal tumor of the mediastinum associated with an esophageal hiatal hernia and chest discomfort: a case report2018

    • Author(s)
      Fujisawa Ryosuke、Akiyama Yuji、Iwaya Takeshi、Endo Fumitaka、Nikai Haruka、Baba Shigeaki、Chiba Takehiro、Kimura Toshimoto、Takahara Takeshi、Otsuka Koki、Nitta Hiroyuki、Mizuno Masaru、Koeda Keisuke、Sasaki Akira
    • Journal Title

      Surgical Case Reports

      Volume: 4 Issue: 1 Pages: 144-144

    • DOI

      10.1186/s40792-018-0553-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thoracoscopic esophagectomy with total meso-esophageal excision reduces regional lymph node recurrence2018

    • Author(s)
      Akiyama Yuji、Iwaya Takeshi、Endo Fumitaka、Nikai Haruka、Sato Kei、Baba Shigeaki、Chiba Takehiro、Kimura Toshimoto、Takahara Takeshi、Otsuka Koki、Nitta Hiroyuki、Mizuno Masaru、Kimura Yusuke、Koeda Keisuke、Sasaki Akira
    • Journal Title

      Langenbeck's Archives of Surgery

      Volume: 403 Issue: 8 Pages: 967-975

    • DOI

      10.1007/s00423-018-1727-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Outcomes of esophagectomy after chemotherapy with biweekly docetaxel plus cisplatin and fluorouracil for advanced esophageal cancer: a retrospective cohort analysis2018

    • Author(s)
      Akiyama Yuji、Sasaki Akira、Endo Fumitaka、Nikai Haruka、Amano Satoshi、Umemura Akira、Baba Shigeaki、Chiba Takehiro、Kimura Toshimoto、Takahara Takeshi、Nitta Hiroyuki、Otsuka Koki、Mizuno Masaru、Kimura Yusuke、Koeda Keisuke、Iwaya Takeshi
    • Journal Title

      World Journal of Surgical Oncology

      Volume: 16 Issue: 1 Pages: 122-122

    • DOI

      10.1186/s12957-018-1420-8

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigation of operative outcomes of thoracoscopic esophagectomy after triplet chemotherapy with docetaxel, cisplatin, and 5-fluorouracil for advanced esophageal squamous cell carcinoma2017

    • Author(s)
      Akiyama Yuji、Iwaya Takeshi、Endo Fumitaka、Chiba Takehiro、Takahara Takeshi、Otsuka Koki、Nitta Hiroyuki、Koeda Keisuke、Mizuno Masaru、Kimura Yusuke、Sasaki Akira
    • Journal Title

      Surgical Endoscopy

      Volume: 32 Issue: 1 Pages: 391-399

    • DOI

      10.1007/s00464-017-5688-5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness of intervention with a perioperative multidisciplinary support team for radical esophagectomy2017

    • Author(s)
      Akiyama Yuji、Iwaya Takeshi、Endo Fumitaka、Shioi Yoshihiro、Kumagai Motoi、Takahara Takeshi、Otsuka Koki、Nitta Hiroyuki、Koeda Keisuke、Mizuno Masaru、Kimura Yusuke、Suzuki Kenji、Sasaki Akira
    • Journal Title

      Supportive Care in Cancer

      Volume: 25 Issue: 12 Pages: 3733-3739

    • DOI

      10.1007/s00520-017-3801-x

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Patient-specific circulating tumor DNA monitoring using esophageal squamous cell cancer gene panel and digital PCR.2019

    • Author(s)
      Iwaya T, Endo F, Sasaki Y, Sasaki N, Yaegashi M, Akiyama Y, Sasaki A, Masuda M, Yamada T, Tokino T, Nishizuka S
    • Organizer
      American Association for Cancer Research (AACR)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 食道癌に対するゲノム医療の可能性と方向性:Circulating tumor DNAモニタリングによる食道癌患者ゲノム情報の有効活用.2019

    • Author(s)
      岩谷 岳、遠藤史隆、千葉丈広、八重樫瑞典、佐々木教之、二階春香、馬場誠朗、秋山有史、佐々木章、西塚 哲
    • Organizer
      第73日本食道学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Post-therapeutic tumor burden monitoring with circulating tumor DNA in esophageal squamous cell carcinoma.2019

    • Author(s)
      Iwaya T, Nishizuka S.
    • Organizer
      第78回日本癌学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 上部消化管癌におけるCirculating tumor DNA 検査に関する検討.2019

    • Author(s)
      岩谷 岳, 遠藤史隆, 千葉丈広, 八重樫瑞典, 佐々木教之, 佐藤慧, 秋山有史, 佐々木章, 西塚 哲.
    • Organizer
      第119回日本外科学会定期 学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Patient-specific circulating tumor DNA monitoring using esophageal squamous cell cancer gene panel and digital PCR2019

    • Author(s)
      Takeshi Iwaya, Fumitaka Endo, Yasushi Sasaki, Noriyuki Sasaki, Mizunori Yaegashi, Yuji Akiyama, Akira Sasaki, Mari Masuda, Tesshi Yamada, Takashi Tokino, Satoshi Nishizuka
    • Organizer
      アメリカ癌学会
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 上部消化管癌における Circulating tumor DNA検査に関する検討2019

    • Author(s)
      岩谷 岳、遠藤 史隆1、千葉 丈広 、八重樫 瑞典 、佐々木 教之、 佐藤 慧 、秋山 有史、佐々木 章 、西塚 哲
    • Organizer
      第119回日本外科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Patient-specific circulating tumor DNA monitoring using digital PCR in esophageal squamous cell cancer patients.2018

    • Author(s)
      Takeshi Iwaya, Fumitaka Endo, Yasushi Sasaki, Mizunori Yaegashi, Kei Sato, Noriyuki Sasaki, Yuji Akiyama, Akira Sasaki, Mari Masuda, Takashi Tokino, Satoshi Nishizuka
    • Organizer
      第77回日本癌学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Therapeutic response monitoring using digital PCR for patient-specific circulating tumor DNA identified by an esophageal squamous cell carcinoma-specific sequencing panel.2018

    • Author(s)
      Takeshi Iwaya, Fumitaka Endo, Yasushi Sasaki, Yuji Akiyama, Akira Sasaki, Mari Masuda, Tesshi Yamada, Takashi Tokino, Satoshi Nishizuka
    • Organizer
      米国臨床腫瘍学会
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 食道癌患者におけるCirculating tumor DNAモニタリングシステムの検討2018

    • Author(s)
      岩谷 岳、遠藤 史隆、秋山 有史、千葉 丈広、馬場 誠朗、梅邑 晃、二階 春香、佐藤 慧、八重樫 瑞典、川岸 涼子、松尾 鉄平、木村 聡元、高原 武志、大塚 幸喜、新田 浩幸、水野 大、肥田 圭介、西塚 哲、佐々木 章
    • Organizer
      第118回日本外科学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Exploitation of a liquid biopsy system using circulating tumor DNA in esophageal cancer patients2017

    • Author(s)
      Takeshi Iwaya, Fumitaka Endo, Yasushi Sasaki, Mizunori Yaegashi, Takehiro Chiba, Yuji Akiyama, Mari Masuda, Tesshi Yamada, Takashi Tokino, Satoshi Nishizuka
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 食道扁平上皮癌パネルを用いた変異解析の有用性の検討2017

    • Author(s)
      岩谷 岳、遠藤 史隆、西塚 哲、秋山 有史、高原 武志、大塚 幸喜、新田 浩幸、肥田 圭介、水野 大、佐々木 章
    • Organizer
      第72回消化器外科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Mutation detection by target sequence analyses using tissue-specific panels in esophageal squamous cell carcinoma2017

    • Author(s)
      Takeshi Iwaya, Fumitaka Endo, Kohei Kume, Yasushi Sasaki, Takashi Tokino, Satoshi Nishizuka
    • Organizer
      アメリカ癌学会
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] がんの診断のためのプローブ・プライマーライブラリー2018

    • Inventor(s)
      岩谷 岳、西塚 哲
    • Industrial Property Rights Holder
      岩手医科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Acquisition Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] がんの診断のためのプローブ/プライマーライブラリー2018

    • Inventor(s)
      西塚哲、岩谷岳
    • Industrial Property Rights Holder
      西塚哲、岩谷岳
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-143912
    • Filing Date
      2018
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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