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The relationship between SNPs and pouchitis after pouch operation in patients with ulcerative colitis

Research Project

Project/Area Number 17K10622
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionThe University of Tokyo

Principal Investigator

Hata Keisuke  東京大学, 医学部附属病院, 特任講師 (60526755)

Co-Investigator(Kenkyū-buntansha) 清松 知充  東京大学, 医学部附属病院, 登録研究員 (00625303)
川合 一茂  東京大学, 医学部附属病院, 講師 (80571942)
野澤 宏彰  東京大学, 医学部附属病院, 准教授 (80529173)
渡邉 聡明  東京大学, 医学部附属病院, 教授 (80210920)
石原 聡一郎  東京大学, 医学部附属病院, 教授 (00376443)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords回腸嚢炎 / 一塩基多型 / 外科
Outline of Final Research Achievements

Major complications in patients with UC include ulcerative colitis (UC)-associated cancer (UCAC) and postoperative pouchitis. We aimed to identify SNPs associated with UCAC/ high-grade dysplasia (HGD) and pouchitis.
The IL1B (rs1143627) TT genotype and preoperative EIM were statistically significant predictors of pouchitis development after IPAA in patients with UC.
None of the selected SNPs were significantly associated with UCAC/HGD in our cohort.

Academic Significance and Societal Importance of the Research Achievements

内科的治療抵抗性の潰瘍性大腸炎や大腸がん合併潰瘍性大腸炎症例に対する治療として大腸全摘が行われます。その際の再建方法として回腸をJ字型に形成し、肛門と吻合する回腸嚢手術を行うことで、永久人工肛門が回避できますが、術後に回腸嚢の中に炎症がおこる回腸嚢炎が問題になります。
本研究では、IL1βのDNAのわずかな違いである一塩基多型が、術後の回腸嚢炎の発症と関係していることが明らかになりました。回腸嚢炎が起こるメカニズムとIL1βとの関わりが示唆されますので、今後、さらにこのメカニズムを調べることにより、回腸嚢炎の治療に役立つ可能性が期待されます。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (2 results)

All 2019

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] A Polymorphism in Interleukin-1β Gene Is Associated with the Development of Pouchitis in Japanese Patients with Ulcerative Colitis2019

    • Author(s)
      Okada S, Hata K, Shinagawa T, Noguchi T, Tanaka T, Kawai K, Nozawa H, Ishihara S
    • Journal Title

      Digestion

      Volume: in press Issue: 3 Pages: 489-498

    • DOI

      10.1159/000503283

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] 日本人の回腸嚢炎発症とUC関連大腸癌のリスク因子の検討2019

    • Author(s)
      岡田聡、畑啓介, 秀野泰隆, 西川武司, 佐々木和人, 金子学, 江本成伸, 室野浩司, 石井博章, 園田洋史, 田中敏明, 川合一茂, 野澤宏彰, 石原聡一郎
    • Organizer
      第10回日本炎症性腸疾患学会学術集会
    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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