| Project/Area Number |
17K10627
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
今野 弘之 浜松医科大学, 医学部, 学長 (00138033)
山本 真義 浜松医科大学, 医学部, 助教 (70397420)
原田 岳 浜松医科大学, 医学部附属病院, 診療助教 (00537251)
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 炎症性腸疾患 / 発癌 / 腸内細菌 / 炎症性発癌 / dysbiosis / 潰瘍性大腸炎 / クローン病 / CAC / 消化器外科学 / 小腸大腸肛門外科学 |
|---|
| Outline of Final Research Achievements |
In the past surgical cases, the condition of FFPE specimens was worse than expected and the DNA quality was poor. Therefore, it was necessary to exclude such cases and we could not reach the target number of cases. In addition, the data of the next-generation sequencer did not reveal any difference in the components of the intestinal flora between IBD cases without cancer and CAC cases, and no bacterial species specific to CAC cases were identified.
|
| Academic Significance and Societal Importance of the Research Achievements |
CAC症例は増加傾向にあり，その発癌メカニズム解明と予防法の確立はIBD患者の予後向上のための喫緊の課題である．現在のところCAC特異的な腸内細菌叢の変化，およびMetaboliteの変化は同定することができていないが，脂質代謝変化などの興味深い知見は得られているため，今後もさらに解析を続けていく予定である．
|
