| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Ftx partially escapes X-inactivation and is upregulated specifically in female ES cells at the onset of X-inactivation, an expression profile which closely follows that of Xist. In adult tissues, FTX expression level was low and its function was not understood. This study aimed to clinical and biological significance of FTX expression in colorectal cancer. FTX expression in colorectal cancer was higher than normal mucosa. Patients with high FTX expression showed significant poorer prognosis compared to patients with low FTX expression. Multiregional regional mutation screening and proteomic analysis revealed heterogeneity in colorectal cancer. FTX mRNA expression could not be detected in most colorectal cancer tissues by real time PCR. Digital PCR analysis revealed the slight difference of FTX expression among multi regions of colorectal primary tumors, even in cases with negative for FTX expression by real time PCR.
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