Role of tissue fibrinolytic factors in NASH liver fibrosis and intrahepatic macrophage activation
| Project/Area Number |
17K10666
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | LDL / apoB100 / Macrophage / Foam cell / NASH / Fibrosis / 線溶因子 / ヒト型高脂血症 / 四塩化炭素 / BCG / マクロファージ / 組織線溶 |
|---|
| Outline of Final Research Achievements |
L-/-/A-/- mouse model is characterized as spontaneous LDL-C driven atherosclerosis model. We have established a NASH model by using L-/-/A-/- mouse model, in which hepatic foam cell formation of macrophages were observed with massive fibrosis.
Since the LDL fraction is hardly observed as a lipoprotein fraction in Wt mice, it will be possible to evaluate the effect of LDL on NASH pathology in our murine system. For the next steps, we are planning to evaluate the effects on cells modified by LDL, especially macrophages, in connection with coagulation/fibrinolytic factors.
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| Academic Significance and Societal Importance of the Research Achievements |
今回作製したNASHモデルは顕著な高LDL血症を示す実験モデルであり、従来のモデルでは評価できないLDLによる病態への影響を評価することが可能となっている。今後NASHにおけるLDLコレステロールの影響に関して本モデルを用いて研究することで、現在有効な治療薬が存在しないNASHにおける有望な治療薬が開発される可能性がある。
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Report
(5 results)
Research Products
(14 results)
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[Journal Article] Hyperfunctioning Papillary Thyroid Carcinoma with a BRAF Mutation: The First Case Report and a Literature Review2021
Author(s)
Shinkai S, Ohba K, Kakudo K, Iwaki T, Mimura Y, Matsushita A, Kuroda G, Sakai Y, Nishino N, Umemura K, Suda T, Sasaki S
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Journal Title
European Thyroid Journal
Volume: -
Issue: 3
Pages: 262-267
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Elevated Plasma Levels of LDL Cholesterol Promote Dissecting Thoracic Aortic Aneurysms in Angiotensin II-Induced Mice.2018
Author(s)
Tanaka H, Iida Y, Iwaki T, Suzuki Y, Sano H, Miyajima C, Zaima N, Sasaki T, Sumioka A, Hakamata S, Shimizu H, Umemura K, Urano T.
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Journal Title
Ann Vasc Surg.
Volume: 48
Pages: 204-213
DOI
Related Report
Peer Reviewed
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[Journal Article] Lysophosphatidylcholine Acyltransferase-3 Expression Is Associated with Atherosclerosis Progression.2017
Author(s)
Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Yata T, Iwaki T, Umemura K, Sano H, Suzuki Y, Urano T, Setou M, Unno N
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Journal Title
J Vasc Res
Volume: 54(4)
Issue: 4
Pages: 200-208
DOI
Related Report
Peer Reviewed
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