| Project/Area Number |
17K10675
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
UENO Masaki 和歌山県立医科大学, 医学部, 講師 (90405465)
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| Co-Investigator(Kenkyū-buntansha) |
速水 晋也 和歌山県立医科大学, 医学部, 講師 (00468290)
川井 学 和歌山県立医科大学, 医学部, 准教授 (40398459)
山上 裕機 和歌山県立医科大学, 医学部, 教授 (20191190)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 腫瘍微小環境 / 肝細胞癌 / 免疫チェックポイント阻害剤 / 原発性肝癌 / 分子標的治療剤 / ゲノム / 癌 / 抗癌剤 |
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| Outline of Final Research Achievements |
There was no significant association between the mutations in the driver genes and expressions in drug sensitivity-related genes. Furthermore, there was no significant relation between expressions of these drug sensitivity-related genes and the therapeutic effects of TACE therapy or molecular-targeted therapies.
Regarding the therapeutic effect in some patients received molecular-targeted therapies, there was a suggestive relation between the degree of infiltration of CD8-positive T cells around the tumor and the therapeutic effect. Therefore, not only gene expression of drug sensitivity-related genes, it was suggested that the condition of the tumor microenvironment strongly affects the therapeutic effect.
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| Academic Significance and Societal Importance of the Research Achievements |
実臨床において薬剤治療効果を推測するには、腫瘍自体の遺伝子変異や、薬物感受性関連遺伝子の発現多寡のみならず、腫瘍微小環境の状態（抗腫瘍免疫の状態や、癌関連線維芽細胞の動態）などの解析を加える必要があることが分かった。
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