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Analysis based on the progression of pancreatic cancer and validation by prospective clinical trial

Research Project

Project/Area Number 17K10689
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Ban Daisuke  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (40376736)

Co-Investigator(Kenkyū-buntansha) 渡邊 秀一  東京医科歯科大学, 医学部附属病院, 助教 (20771827)
田中 真二  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30253420)
田邉 稔  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (50197513)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords膵癌 / 局所進行膵癌 / オリゴ転移 / 局所進行切除不能膵癌 / 薬剤感受性 / 術前化学療法 / Conversion Surgery
Outline of Final Research Achievements

It has been suggested that there may be cases in which surgical treatment is successful even in advanced pancreatic cancer. In general, cases that would benefit from resection are considered to be tumors of a localized nature with no distant metastases. It was examined in oligo metastases cases, and in clinical trial to introduce surgical treatment for advanced pancreatic cancer.
Although we intended to include patients with no distant metastases in the clinical trial, some patients developed distant metastases as a result of the study were found to be unsuitable for this study. A longitudinal analysis of the gene mutation profile was performed by reviewing previous cases of oligo metastasis. Phylogenetic analysis of the profile revealed that the next metastasis arose from a metastasis and that a new subclone was formed at the metastasis.

Academic Significance and Societal Importance of the Research Achievements

現在、遠隔転移を伴う膵癌や局所進行膵癌に対する標準治療は化学療法であるが、根治性が得られる治療選択はなく、予後も不良である。本研究の目的はそのような進行膵癌であっても根治性が期待できるような、あるいは予後に有効な外科的治療介入の可能性を探索することであった。切除後に再発を来した膵癌であってもオリゴ転移と考えて良い過去の再発巣切除例の遺伝子プロファイルを検討することによって、その機序と遺伝子プロファイルの一端を明らかにできたことは今後の患者選択を検討する上での基盤を提供することできたと考える。さらにこれらの研究を進めていくことによって臨床に実装されることを期待したい。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (36 results)

All 2020 2019 2018 2017

All Journal Article (24 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 24 results,  Open Access: 9 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Combination of weekly streptozocin and oral S-1 treatment for patients of unresectable or metastatic pancreatic neuroendocrine neoplasms.2020

    • Author(s)
      Ono H, Kudo A, Akahoshi K, Ogura T, Ogawa K, Ban D, Tanaka S, Tanabe M.
    • Journal Title

      Journal of Cancer Research and Clinical Oncology

      Volume: 146 Issue: 3 Pages: 793-799

    • DOI

      10.1007/s00432-019-03109-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Position of the pancreas division line and postoperative outcomes after distal pancreatectomy.2020

    • Author(s)
      Matsui S, Ogura T, Ban D, Ogawa K, Ono H, Mitsunori Y, Kudo A, Tanaka S, Tanabe M.
    • Journal Title

      World Journal of Surgery

      Volume: 44 Issue: 4 Pages: 1244-1251

    • DOI

      10.1007/s00268-019-05305-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reticular pattern around SMA in CT imaging predicting poor prognosis of pancreatic head cancer.2020

    • Author(s)
      Kato T, Ban D, Tateishi U, Ogura T, Ogawa K, Ono H, Mitsunori Y, Kudo A, Tanaka S, Tanabe M.
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: 27 Issue: 3 Pages: 114-123

    • DOI

      10.1002/jhbp.700

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The clinical implications of peripancreatic fluid collection after distal pancreatectomy.2019

    • Author(s)
      Yoshino J, Ban D, Ogura T, Ogawa K, Ono H, Mitsunori Y, Kudo A, Tanaka S, Tanabe M.
    • Journal Title

      World Journal of Surgery

      Volume: 43 Issue: 8 Pages: 2069-2076

    • DOI

      10.1007/s00268-019-05009-8

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality2019

    • Author(s)
      Watanabe S, Shimada S, Akiyama Y, Ishikawa Y, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Yamaoka S, Tanabe M, Tanaka S.
    • Journal Title

      International Journal of Cancer

      Volume: - Issue: 1 Pages: 192-205

    • DOI

      10.1002/ijc.32072

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A simple and practical index predicting the prognoses of the patients with well-differentiated pancreatic neuroendocrine neoplasms.2019

    • Author(s)
      Liu B, Kudo A, Kinowaki Y, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Tanaka S, Akashi T, Tanabe M.
    • Journal Title

      J Gastroenterol.

      Volume: - Issue: 9 Pages: 819-828

    • DOI

      10.1007/s00535-019-01570-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comprehensive molecular characterization of liver cancer and inheritance of the phenotypic traits during tumor recurrence.2019

    • Author(s)
      Shimada S, Mogushi K, Akiyama Y, Furuyama T, Watanabe S, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Tanabe M, Wands JR, Tanaka S.
    • Journal Title

      EBioMedicine

      Volume: 40 Pages: 457-470

    • DOI

      10.1016/j.ebiom.2018.12.058

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rapid growth speed of cysts can predict malignant intraductal mucinous papillary neoplasms.2018

    • Author(s)
      Akahoshi K, Ono H, Akasu M, Ban D, Kudo A, Konta A, Tanaka S, Tanabe M.
    • Journal Title

      J Surg Res

      Volume: 231 Pages: 195-200

    • DOI

      10.1016/j.jss.2018.05.056

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Difficulty scoring system in laparoscopic distal pancreatectomy.2018

    • Author(s)
      Ohtsuka T, Ban D, Nakamura Y, Nagakawa Y, Tanabe M, Gotoh Y, Velasquez VVDM, Nakata K, Sahara Y, Takaori K, Honda G, Misawa T, Kawai M, Yamaue H, Morikawa T, Kuroki T, Mou Y, Lee WJ, Shrikhande SV, Tang CN, Conrad C, Han HS, Palanivelu C, Asbun HJ, Kooby DA, Wakabayashi G, Takada T, Yamamoto M, Nakamura M.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 25 Issue: 11 Pages: 489-497

    • DOI

      10.1002/jhbp.578

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Downregulated Pancreatic Beta Cell Genes Indicate Poor Prognosis in Patients With Pancreatic Neuroendocrine Neoplasms.2018

    • Author(s)
      Kudo A, Akahoshi K, Ito S, Akashi T, Shimada S, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Tateishi U, Tanaka S, Tanabe M.
    • Journal Title

      Ann Surg.

      Volume: - Issue: 4 Pages: 732-739

    • DOI

      10.1097/sla.0000000000002911

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Minimally invasive preservation versus splenectomy during distal pancreatectomy: a systematic review and meta-analysis2018

    • Author(s)
      Nakata K, Shikata S, Ohtsuka T, Ukai T, Miyasaka Y, Mori Y, Velasquez VVDM, Gotoh Y, Ban D, et al.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 25 Issue: 11 Pages: 476

    • DOI

      10.1002/jhbp.569

    • URL

      https://pure.teikyo.jp/en/publications/b34f5cfe-7160-4c03-9781-622da9efd2e4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Current topics in the surgical treatments for hepatocellular carcinoma2018

    • Author(s)
      Ban Daisuke、Ogura Toshiro、Akahoshi Keiichi、Tanabe Minoru
    • Journal Title

      Annals of Gastroenterological Surgery

      Volume: 2 Issue: 2 Pages: 137-146

    • DOI

      10.1002/ags3.12065

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-dimensional computed tomography analysis of the vascular anatomy of the splenic hilum for gastric cancer surgery.2018

    • Author(s)
      Ishikawa Y, Ehara K, Yamada T, Matsuzawa N, Arai S, Ban D, Kudo A, Tanabe M, Kawashima Y, Sakamoto H.
    • Journal Title

      Surg Today.

      Volume: 48 Issue: 9 Pages: 841-847

    • DOI

      10.1007/s00595-018-1679-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Splenic artery as a simple landmark indicating difficulty during laparoscopic distal pancreatectomy2018

    • Author(s)
      Ishikawa Yoshiya、Ban Daisuke、Watanabe Shuichi、Akahoshi Keiichi、Ono Hiroaki、Mitsunori Yusuke、Kudo Atsushi、Tanaka Shinji、Tanabe Minoru
    • Journal Title

      Asian Journal of Endoscopic Surgery

      Volume: - Issue: 1 Pages: 81-87

    • DOI

      10.1111/ases.12485

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sunitinib shrinks NET-G3 pancreatic neuroendocrine neoplasms2018

    • Author(s)
      Mizuno Yuki、Kudo Atsushi、Akashi Takumi、Akahoshi Keiichi、Ogura Toshiro、Ogawa Kosuke、Ono Hiroaki、Mitsunori Yusuke、Ban Daisuke、Tanaka Shinji、Tateishi Ukihide、Tanabe Minoru
    • Journal Title

      Journal of Cancer Research and Clinical Oncology

      Volume: - Issue: 6 Pages: 1155-1163

    • DOI

      10.1007/s00432-018-2636-2

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fatty Acid Binding Protein 4 (FABP4) Overexpression in Intratumoral Hepatic Stellate Cells within Hepatocellular Carcinoma with Metabolic Risk Factors.2018

    • Author(s)
      Chiyonobu N, Shimada S, Akiyama Y, Mogushi K, Itoh M, Akahoshi K, Matsumura S, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Suganami T, Yamaoka S, Ogawa Y, Tanabe M, Tanaka S.
    • Journal Title

      Am J Pathol.

      Volume: 188 Pages: 1213-1224

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma2018

    • Author(s)
      Mizuno Y, Shimada S, Akiyama Y, Watanabe S, Aida T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Yamaoka S, Tanabe M, Tanaka S
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 106-106

    • DOI

      10.1038/s41598-017-18323-9

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor suppressor functions of DAXX through histone H3.3/H3K9me3 pathway in pancreatic NETs.2018

    • Author(s)
      Ueda H, Akiyama Y, Shimada S, Mogushi K, Serizawa M, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S.
    • Journal Title

      Endocr Relat Cancer

      Volume: 25(6) Issue: 6 Pages: 619-631

    • DOI

      10.1530/erc-17-0328

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fatty Acid Binding Protein 4 (FABP4) Overexpression in Intratumoral Hepatic Stellate Cells within Hepatocellular Carcinoma with Metabolic Risk Factors2018

    • Author(s)
      Chiyonobu Norimichi、Shimada Shu、Akiyama Yoshimitsu、Mogushi Kaoru、Itoh Michiko、Akahoshi Keiichi、Matsumura Satoshi、Ogawa Kosuke、Ono Hiroaki、Mitsunori Yusuke、Ban Daisuke、Kudo Atsushi、Arii Shigeki、Suganami Takayoshi、Yamaoka Shoji、Ogawa Yoshihiro、Tanabe Minoru、Tanaka Shinji
    • Journal Title

      Am. J. Pathol.

      Volume: 188 Issue: 5 Pages: 1213-1224

    • DOI

      10.1016/j.ajpath.2018.01.012

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A simple morphological classification to estimate the malignant potential of pancreatic neuroendocrine tumors2017

    • Author(s)
      Oba Atsushi、Kudo Atsushi、Akahoshi Keiichi、Kishino Mitsuhiro、Akashi Takumi、Katsuta Eriko、Iwao Yasuhito、Ono Hiroaki、Mitsunori Yusuke、Ban Daisuke、Tanaka Shinji、Eishi Yoshinobu、Tateishi Ukihide、Tanabe Minoru
    • Journal Title

      Journal of Gastroenterology

      Volume: 52 Issue: 10 Pages: 1140-1146

    • DOI

      10.1007/s00535-017-1349-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surgical pitfalls of jejunal vein anatomy in pancreaticoduodenectomy2017

    • Author(s)
      Ishikawa Yoshiya、Ban Daisuke、Matsumura Satoshi、Mitsunori Yusuke、Ochiai Takanori、Kudo Atsushi、Tanaka Shinji、Tanabe Minoru
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: 24 Issue: 7 Pages: 394-400

    • DOI

      10.1002/jhbp.451

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acquired resistance with epigenetic alterations under long-term anti-angiogenic therapy for hepatocellular carcinoma.2017

    • Author(s)
      Ohata Y, Akiyama Y, Shimada S, Mogushi K, Nakao K, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S.
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: in press Issue: 6 Pages: 1155-1165

    • DOI

      10.1158/1535-7163.mct-16-0728

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ARID2 modulates DNA damage response in human hepatocellular carcinoma cells.2017

    • Author(s)
      Oba A, Shimada S, Akiyama Y, Nishikawaji T, Mogushi K, Ito H, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Asahara H, Kaida A, Miura M, Tanabe M, Tanaka S.
    • Journal Title

      Journal of Hepatology

      Volume: in press Issue: 5 Pages: 942-951

    • DOI

      10.1016/j.jhep.2016.12.026

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Refractory Long-Term Cholangitis After Pancreaticoduodenectomy: A Retrospective Study2017

    • Author(s)
      Ueda Hiroki、Ban Daisuke、Kudo Atsushi、Ochiai Takanori、Tanaka Shinji、Tanabe Minoru
    • Journal Title

      World Journal of Surgery

      Volume: 41 Issue: 7 Pages: 1882-1889

    • DOI

      10.1007/s00268-017-3912-z

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] THE IMPLICATION OF INDUCTION CHEMOTHERAPY FOLLOWED BY CHEMORADIOTHERAPY FOR LOCALLY ADVANCED PANCREATIC CANCER, INTENDED CONVERSION SURGERY2019

    • Author(s)
      Daisuke Ban, Toshitaka Sugawara, Tomotaka Kato, Atsushi Kudo, Minoru Tanabe
    • Organizer
      53rd annual meeting of Pancreas club
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PREOPERATIVE FACTORS FOR EARLY RECURRENCE OF RESECTED PANCREATIC DUCTAL ADENOCARCINOMA2019

    • Author(s)
      Toshitaka Sugawara, Daisuke Ban, Shuichi Watanabe, Toshiro Ogura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Atsushi Kudo, Minoru Tanabe
    • Organizer
      53rd annual meeting of Pancreas club
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膵 癌の縦断的whole exome sequence 解析によるfounder mutation 推定の試み.2019

    • Author(s)
      渡辺秀一、伴 大輔、西野 穣、石井 武、松井 聡、菅原俊喬、赤須雅文、加藤智敬、浅野大輔、吉野  潤、小倉俊郎、小川康介、小野宏晃、光法雄介、工藤 篤、田中真二、鎌谷高志、宮 冬樹、田邉 稔.
    • Organizer
      第119 回日本外科学会定期学 術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The efficacy of induction chemotherapy for locally advanced pancreatic cancer, intended conversion surgery.2019

    • Author(s)
      Daisuke Ban.
    • Organizer
      The 65th annual congress of international college of surgeons Japan section
    • Related Report
      2019 Annual Research Report
  • [Presentation] 局所進行切除不能膵癌に対する導 入化学療法と化学放射線療法によるConvwrsion surgery の意義.2019

    • Author(s)
      伴 大輔、加藤智敬、小倉俊郎、小川康介、小野宏晃、工藤 篤、田邉 稔.
    • Organizer
      第28 回日本癌病態治療研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 下大静脈高度腫瘍浸潤・腫瘍栓症例に対する多領域外科の協力による総合戦略2017

    • Author(s)
      伴大輔、大井啓司、工藤敏文、齋藤一隆、巌康仁、松村聡、光法雄介、小野宏晃、落合高徳、工藤篤、水野友裕、田中真二、藤井靖久、井上芳徳、荒井裕国、田邉稔
    • Organizer
      第117回 日本外科学会定期学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] How to set up difficulty scoring system in laparoscopic liver resection2017

    • Author(s)
      Daisuke Ban、Minoru Tanabe
    • Organizer
      6th A-PHPBA 29th JSHBPS
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Safely expanding of the laparoscopic liver resection according to difficulty scoring system2017

    • Author(s)
      Daisuke Ban, Jun Yoshino, Toshiro Ogura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Atsushi Kudo, Minoru Tanabe
    • Organizer
      The 63rd Annual Congress of International College of Surgeons Japan Section
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Safely expanding of the laparoscopic liver resection according to difficulty scoring system2017

    • Author(s)
      Ban Daisuke, Ogura Toshiro, Yoshino Jun, Akahoshi Keiichi, Mitsunori Yusuke, Ono Hiroaki, Kudo Atsushi, Tanabe Minoru
    • Organizer
      International Laparoscopic Liver Society 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] BR膵癌のCT画像膵外進展評価における淡い網目状高吸収所見の意義2017

    • Author(s)
      伴 大輔、浅野 大輔、吉野 潤、渡辺 秀一、水野 裕貴、千代延 記道、赤星 径一、小倉 俊郎、小川 康介、小野 宏晃、光法 雄介、工藤 篤、田中 真二、田邉 稔
    • Organizer
      第48回 日本膵臓学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 膵体尾部切除における膵液瘻予防のためのBest Practice~断端被覆と管理の変遷2017

    • Author(s)
      伴大輔、吉野潤、加藤智敬、赤須雅文、赤星径一、小川康介、小野宏晃、光法雄介、工藤篤、田中真二、田邉稔
    • Organizer
      第44回 日本膵切研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 腹腔鏡下肝切除におけるDifficulty Scoring Systemの課題と今後の展望2017

    • Author(s)
      伴大輔、加藤智敬、赤須雅文、吉野潤、渡辺秀一、千代延記道、水野裕貴、赤星径一、小倉俊郎、小川康介、小野宏晃、光法雄介、工藤篤、田中真二、田邉稔
    • Organizer
      第30回日本内視鏡外科学会総会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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