Expression and activity of ion transporters in pancreatic cancer stem cells.

• Project/Area Number: 17K10710
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Toma Atsushi 京都府立医科大学, 医学(系)研究科(研究院), 講師 (30516191)
• Co-Investigator(Kenkyū-buntansha): 大辻 英吾 京都府立医科大学, 医学(系)研究科(研究院), 教授 (20244600) ; 塩崎 敦 京都府立医科大学, 医学(系)研究科(研究院), 助教 (40568086)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 膵癌 / 膵臓外科学 / 癌幹細胞 / イオンチャネル

Outline of Final Research Achievements

Cells exhibiting strong ALDH1 activity were isolated from PK59 pancreatic cancer cells by cell sorting, and cancer stem cells (CSCs) were then generated with the sphere formation assay. The gene expression profiles of CSCs were examined by microarray analysis, and the expression of 57 genes related to ion channels, including voltage-gated potassium channel (Kv), was upregulated. The Kv inhibitor, 4-aminopyridine (4-AP) was more cytotoxic at a lower concentration in CSCs than in non-CSCs, and effectively decreased the number of tumorspheres. Furthermore, 4-AP significantly decreased the cell population that strongly expressed ALDH1 among PK59 cells. In a xenograft model in nude mice, injection of PK59 cells treated with 4-AP resulted in significantly smaller tumor volumes than those of nontreated cells. These results suggest that Kv is involved in the maintenance of CSCs, and that its specific inhibitor, 4-AP, has potential as a targeted therapeutic agent against pancreatic carcinoma.

Academic Significance and Societal Importance of the Research Achievements

電位依存性カリウムチャネルが膵癌幹細胞において高発現し、その阻害剤である4-aminopyridineが癌幹細胞特異的に抑制効果を示すことを新たに見出した。4-aminopyridineは多発性硬化症に対し臨床で用いられている薬剤であり、その抗腫瘍効果を明らかにしたことの社会的意義は大きいと考えられる。

Research Products

• [Journal Article] ANO9 Regulated Cell Cycle in Human Esophageal Squamous Cell Carcinoma. (2020)
  • Author(s): Katsurahara K, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.
  • Journal Title: Ann Surg Oncol. Volume: ー Issue: 9 Pages: 3218-3230
  • DOI: 10.1245/s10434-020-08368-y
  • Peer Reviewed
• [Journal Article] Case of a 5mm Rectal Neuroendocrine Tumor(G1)with Lymph Node Metastasis. (2020)
  • Author(s): Takemoto K, Harada K, Toma A, Imura T, Ochiai T, Otsuji E.
  • Journal Title: Gan To Kagaku Ryoho. Volume: 47 Pages: 652-654
  • Peer Reviewed
• [Journal Article] The expression and role of TRPV2 in esophageal squamous cell carcinoma. (2019)
  • Author(s): Kudou M, Shiozaki A, Yamazato Y, Katsurahara K, Kosuga T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 16055-16055
  • DOI: 10.1038/s41598-019-52227-0
  • Peer Reviewed / Open Access
• [Journal Article] Effect of low temperature on the regulation of cell volume after hypotonic shock in gastric cancer cells. (2019)
  • Author(s): Shiozaki A, Yamazato Y, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E.
  • Journal Title: Int J Oncol. Volume: 55 Pages: 905-914
  • DOI: 10.3892/ijo.2019.4853
  • Peer Reviewed
• [Journal Article] LRRC8A Expression Influences Growth of Esophageal Squamous Cell Carcinoma. (2019)
  • Author(s): Konishi T, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.
  • Journal Title: Am J Pathol. Volume: 189 Issue: 10 Pages: 1973-1985
  • DOI: 10.1016/j.ajpath.2019.06.006
  • Peer Reviewed
• [Journal Article] Outcome of a second hepatectomy in octogenarians with hepatocellular carcinoma recurrence: single centre's experience. (2019)
  • Author(s): Ochiai T, Inoue H, Watanabe N, Ito H, Toma A, Morimura R, Ikoma H, Otsuji E.
  • Journal Title: ANZ J Surg. Volume: 89 Issue: 10 Pages: 1270-1274
  • DOI: 10.1111/ans.15330
  • Peer Reviewed
• [Journal Article] 超高齢者小腸結核穿孔の1例 (2019)
  • Author(s): 満田 雅人, 渡邉 信之, 伊藤 博士, 當麻 敦史, 真崎 武, 落合 登志哉, 大辻 英吾
  • Journal Title: 京都府立医科大学雑誌 Volume: 128 Pages: 19-25
  • Peer Reviewed
• [Journal Article] Successful curative resection after chemotherapy for initially unresectable advanced gallbladder cancer with rectal metastasis:a case report (2018)
  • Author(s): 井上 博之、當麻 敦史、渡邉 信之、伊藤 博士、落合 登志哉、大辻 英吾
  • Journal Title: Nippon Shokakibyo Gakkai Zasshi Volume: 115 Issue: 10 Pages: 905-913
  • DOI: 10.11405/nisshoshi.115.905
  • NAID: 130007496596
  • ISSN: 0446-6586, 1349-7693
  • Year and Date: 2018-10-10
  • Peer Reviewed
• [Journal Article] Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer (2018)
  • Author(s): Shiozaki Atsushi、Ariyoshi Yosuke、Iitaka Daisuke、Kosuga Toshiyuki、Shimizu Hiroki、Kudou Michihiro、Konishi Tomoki、Shoda Katsutoshi、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Marunaka Yoshinori、Ichikawa Daisuke、Otsuji Eigo
  • Journal Title: Gastric Cancer Volume: 22 Issue: 3 Pages: 473-485
  • DOI: 10.1007/s10120-018-0874-2
  • NAID: 40021884050
  • Peer Reviewed
• [Journal Article] Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma (2018)
  • Author(s): Shiozaki A, Hikami S, Ichikawa D, Kosuga T, Shimizu H, Kudou M, Yamazato Y, Kobayashi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E
  • Journal Title: Oncotarget Volume: 9 Issue: 40 Pages: 25993-26006
  • DOI: 10.18632/oncotarget.25417
  • Peer Reviewed / Open Access
• [Journal Article] Aquaporin 1 suppresses apoptosis and affects prognosis in esophageal squamous cell carcinoma (2018)
  • Author(s): Yamazato Yuzo、Shiozaki Atsushi、Ichikawa Daisuke、Kosuga Toshiyuki、Shoda Katsutoshi、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Marunaka Yoshinori、Otsuji Eigo
  • Journal Title: Oncotarget Volume: 9 Issue: 52 Pages: 29957-29974
  • DOI: 10.18632/oncotarget.25722
  • Peer Reviewed / Open Access
• [Journal Article] Chloride intracellular channel 1 as a switch among tumor behaviors in human esophageal squamous cell carcinoma (2018)
  • Author(s): Kobayashi Toshiyuki、Shiozaki Atsushi、Nako Yoshito、Ichikawa Daisuke、Kosuga Toshiyuki、Shoda Katsutoshi、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Marunaka Yoshinori、Otsuji Eigo
  • Journal Title: Oncotarget Volume: 9 Issue: 33 Pages: 23237-23252
  • DOI: 10.18632/oncotarget.25296
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Feeding Jejunostomy via Gastric Tube Versus Jejunum After Esophageal Cancer Surgery (2018)
  • Author(s): KONISHI TOMOKI、SHIOZAKI ATSUSHI、FUJIWARA HITOSHI、KONISHI HIROTAKA、TAKEMOTO KENICHI、KUDOU MICHIHIRO、SHODA KATSUTOSHI、ARITA TOMOHIRO、KOSUGA TOSHIYUKI、MORIMURA RYO、MURAYAMA YASUTOSHI、KURIU YOSHIAKI、IKOMA HISASHI、KUBOTA TAKESHI、NAKANISHI MASAYOSHI、OKAMOTO KAZUMA、OTSUJI EIGO
  • Journal Title: Anticancer Research Volume: 38 Issue: 8 Pages: 4941-4945
  • DOI: 10.21873/anticanres.12811
  • Peer Reviewed
• [Journal Article] Relationship Between Postoperative CRP and Prognosis in Thoracic Esophageal Squamous Cell Carcinoma (2018)
  • Author(s): KATSURAHARA KEITA、SHIOZAKI ATSUSHI、FUJIWARA HITOSHI、KONISHI HIROTAKA、KUDOU MICHIHIRO、SHODA KATSUTOSHI、ARITA TOMOHIRO、KOSUGA TOSHIYUKI、MORIMURA RYO、MURAYAMA YASUTOSHI、KURIU YOSHIAKI、IKOMA HISASHI、KUBOTA TAKESHI、NAKANISHI MASAYOSHI、OKAMOTO KAZUMA、OTSUJI EIGO
  • Journal Title: Anticancer Research Volume: 38 Issue: 11 Pages: 6513-6518
  • DOI: 10.21873/anticanres.13016
  • Peer Reviewed
• [Journal Article] Glutathione S‐transferase Pi 1 is a valuable predictor for cancer drug resistance in esophageal squamous cell carcinoma (2018)
  • Author(s): Ogino Shinpei、Konishi Hirotaka、Ichikawa Daisuke、Matsubara Daiki、Shoda Katsutoshi、Arita Tomohiro、Kosuga Toshiyuki、Komatsu Shuhei、Shiozaki Atsushi、Okamoto Kazuma、Kishimoto Mitsuo、Otsuji Eigo
  • Journal Title: Cancer Science Volume: 110 Issue: 2 Pages: 795-804
  • DOI: 10.1111/cas.13896
  • Peer Reviewed
• [Journal Article] Detection of fusion gene in cell-free DNA of a gastric synovial sarcoma. (2018)
  • Author(s): Ogino S, Konishi H, Ichikawa D, Hamada J, Shoda K, Arita T, Komatsu S, Shiozaki A, Okamoto K, Yamazaki S, Yasukawa S, Konishi E, Otsuji E.
  • Journal Title: World J Gastroenterol. Volume: 24 Issue: 8 Pages: 949-956
  • DOI: 10.3748/wjg.v24.i8.949
  • Peer Reviewed / Open Access
• [Journal Article] 急性虫垂炎で発症した小児虫垂カルチノイドの1例 (2018)
  • Author(s): 満田 雅人, 渡邉 信之, 伊藤 博士, 當麻 敦史, 真崎 武, 落合 登志哉, 大辻 英吾
  • Journal Title: 京都府立医科大学雑誌 Volume: 127 Pages: 679-684
  • Peer Reviewed
• [Journal Article] Esophageal cancer stem cells are suppressed by tranilast, a TRPV2 channel inhibitor. (2017)
  • Author(s): Shiozaki A, Kudou M, Ichikawa D, Fujiwara H, Shimizu H, Ishimoto T, Arita T, Kosuga T, Konishi H, Komatsu S, Okamoto K, Marunaka Y, Otsuji E.
  • Journal Title: J Gastroenterol Volume: 印刷中 Issue: 2 Pages: 197-207
  • DOI: 10.1007/s00535-017-1338-x
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Expression and role of anion exchanger 1 in esophageal squamous cell carcinoma. (2017)
  • Author(s): Shiozaki A, Kudou M, Ichikawa D, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E.
  • Journal Title: Oncotarget Volume: 8 Issue: 11 Pages: 17921-17935
  • DOI: 10.18632/oncotarget.14900
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Regulation of osmolality for cancer treatment. (2017)
  • Author(s): Shiozaki A, Ichikawa D, Kosuga T, Marunaka Y, Otsuji E.
  • Journal Title: J Physiol Sci Volume: 印刷中 Issue: 3 Pages: 353-360
  • DOI: 10.1007/s12576-017-0528-x
  • NAID: 40021176358
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Na+/H+ exchanger 1 has tumor suppressive activity and prognostic value in esophageal squamous cell carcinoma. (2017)
  • Author(s): Ariyoshi Y, Shiozaki A, Ichikawa D, Shimizu H, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E.
  • Journal Title: Oncotarget Volume: 10 Issue: 2 Pages: 2209-2223
  • DOI: 10.18632/oncotarget.13645
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer (2017)
  • Author(s): Kosuga Toshiyuki、Shiozaki Atsushi、Kudou Michihiro、Yamazato Yuzo、Ichikawa Daisuke、Komatsu Shuhei、Konishi Hirotaka、Okamoto Kazuma、Shoda Katsutoshi、Arita Tomohiro、Morimura Ryo、Murayama Yasutoshi、Kuriu Yoshiaki、Ikoma Hisashi、Nakanishi Masayoshi、Fujiwara Hitoshi、Marunaka Yoshinori、Otsuji Eigo
  • Journal Title: Oncotarget Volume: 8 Issue: 60 Pages: 101394-101405
  • DOI: 10.18632/oncotarget.20736
  • Peer Reviewed / Open Access
• [Journal Article] Heat shock exerts anticancer effects on liver cancer via autophagic degradation of aquaporin 5. (2017)
  • Author(s): Kudou M, Shiozaki A, Kosuga T, Shimizu H, Ichikawa D, Konishi H, Morimura R, Komatsu S, Ikoma H, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E.
  • Journal Title: Int J Oncol Volume: 50 Issue: 5 Pages: 1857-1867
  • DOI: 10.3892/ijo.2017.3940
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Transient Receptor Potential Melastatin 7 as an Independent Prognostic Factor in Human Esophageal Squamous Cell Carcinoma. (2017)
  • Author(s): Nakashima S, Shiozaki A, Ichikawa D, Hikami S, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.
  • Journal Title: Anticancer Res Volume: 37 Issue: 3 Pages: 1161-1167
  • DOI: 10.21873/anticanres.11429
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Role of cIAP1 and XIAP in Apoptosis Induced by Tumor Necrosis Factor Alpha in Esophageal Squamous Cell Carcinoma Cells. (2017)
  • Author(s): Hikami S, Shiozaki A, Kitagawa-Juge M, Ichikawa D, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Otsuji E.
  • Journal Title: Dig Dis Sci Volume: 印刷中 Issue: 3 Pages: 652-659
  • DOI: 10.1007/s10620-016-4430-9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A Case Report of an Elderly Patient's Intrahepatic Cholangiocellular Carcinoma with Cholangitis (2017)
  • Author(s): Ito H, Ochiai T, Nakatsuji H, Inoue H, Watanabe N, Yoshiyama A, Toma A, Nakamura K, Otsuji E.
  • Journal Title: Gan To Kagaku Ryoho Volume: 44 Pages: 1823-1825
  • Peer Reviewed
• [Journal Article] A Successful Curative Resection Case of Metastatic Hepatocellular Carcinoma to the Kidney Which Extended into the Renal Vein (2017)
  • Author(s): Inoue H, Ochiai T, Nakatsuji H, Watanabe N, Ito H, Yoshiyama A, Toma A, Nakamura K, Otsuji E.
  • Journal Title: Gan To Kagaku Ryoho Volume: 44 Pages: 1820-1822
  • Peer Reviewed
• [Journal Article] Long-Term Survival of a Patient with Metastatic Liver and Para-Aortic Lymph Node Cancer from Colon Cancer Treated with Regorafenib (2017)
  • Author(s): Watanabe N, Akagi S, Inoue H, Nakatsuji H, Ito H, Toma A, Nakamura K, Ochiai T, Otsuji E.
  • Journal Title: Gan To Kagaku Ryoho Volume: 44 Pages: 1732-1734
  • Peer Reviewed
• [Journal Article] Neoadjuvant FOLFIRINOX for Unresectable Adenocarcinoma of the Pancreas - A Case Report (2017)
  • Author(s): Ochiai T, Inoue H, Nakatsuji H, Watanabe N, Yoshiyama A, Ito H, Toma A, Nakamura K.
  • Journal Title: Gan To Kagaku Ryoho Volume: 44 Pages: 1349-1351
  • Peer Reviewed
• [Presentation] 食道扁平上皮癌におけるTRPV2発現の臨床病理学的意義についての検討 (2019)
  • Author(s): 加藤俊治、塩﨑敦、山里有三、小菅敏幸、小西博貴、窪田健、藤原斉、岡本和真、岸本光夫、森村玲、生駒久視、村山康利、栗生宜明、中西正芳、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 膵癌幹細胞における4-aminopyridineの抗腫瘍効果について (2019)
  • Author(s): 小西智規、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 食道癌におけるLeucine-Rich Repeat-Containing protein 8A（LRRC8A）発現と機能解析 (2019)
  • Author(s): 倉島研人、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるAno9発現の意義 (2019)
  • Author(s): 葛原啓太、塩﨑敦、工藤道弘、庄田勝俊、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] ヒト食道扁平上皮癌におけるNa+/K+-ATPase発現と役割 (2019)
  • Author(s): 小林利行、塩﨑敦、工藤道弘、小菅敏幸、庄田勝俊、有田智洋、小西博貴、小松周平、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、小西英一、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるCLC-2（Chloride Channel protein 2）発現の意義 (2019)
  • Author(s): 満田雅人、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるCFTR（cystic fibrosis transmembrane conductance regulator）の発現の意義 (2019)
  • Author(s): 松本順久、塩﨑敦、工藤道弘、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 胃癌細胞の低浸透圧処理後容積変化における低温刺激の影響 (2019)
  • Author(s): 中村慶、塩﨑敦、小菅敏幸、山里有三、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾.
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 低浸透圧による細胞容積制御を介した胃癌細胞へのパクリタキセル取り込み増強効果 (2019)
  • Author(s): 小菅敏幸、塩﨑敦、工藤道弘、飯高大介、小林利行、竹本健一、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、岡本和真、藤原斉、小松周平、市川大輔、大辻英吾.
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] High CD44 gastric cancer stem cells are suppressed by voltage gated Ca2+ channel blocker. (2019)
  • Author(s): Keita Katsurahara, Atsushi Shiozaki, Michihiro Kudou, Katsutoshi Shoda, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Ryo Morimura, Yasutoshi Murayama, Takeshi Kubota, Masayoshi Nakanishi, Hitoshi Fujiwara, Eigo Otsuji.
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] The development of novel targeted therapies to over-expressed ion transporters in esophageal cancer stem cells. (2019)
  • Author(s): Yoshihisa Matsumoto, Michihiro Kudou, Atsushi Shiozaki, Toshiyuki Kosuga, Ryo Morimura , Yasutoshi Murayama, Yoshiaki Kuriu , Hisashi Ikoma, Takeshi Kubota, Masayoshi Nakanishi, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji.
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] 胃癌におけるヨウ化ナトリウム共輸送体のIFNシグナルを介する腫瘍制御機構の解明 (2019)
  • Author(s): 塩﨑敦、有吉要輔、小菅敏幸、工藤道弘、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第57回日本癌治療学会学術集会
• [Presentation] 食道癌幹細胞特異的に発現するion channelの同定と新規標的治療への応用 (2018)
  • Author(s): 塩﨑敦, 工藤道弘, 藤原斉, 小西博貴, 庄田勝俊, 有田智洋, 小菅敏幸, 森村玲, 村山康利, 栗生宜明, 生駒久視, 窪田健, 中西正芳, 岡本和真, 大辻英吾
  • Organizer: JDDW2018（第16回日本消化器外科学会大会）
• [Presentation] 食道扁平上皮癌におけるAnion exchanger 2の細胞遊走能制御機構の解明 (2018)
  • Author(s): 塩﨑敦、樋上翔一郎、小菅敏幸、工藤道弘、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第56回日本癌治療学会学術集会
• [Presentation] 食道癌幹細胞に高発現する TRPV2 を標的とした新たな治療方法の開発 (2018)
  • Author(s): 葛原啓太、塩﨑敦、工藤道弘、庄田勝俊、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌における Na+/K+-ATPase の発現意義 (2018)
  • Author(s): 松本順久、塩﨑敦、小林利行、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌における Aquaporin 1 の発現機能 (2018)
  • Author(s): 山里有三、塩﨑敦、庄田勝俊、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌における CLIC1 の発現意義と機能解析 (2018)
  • Author(s): 小林利行、塩﨑敦、名幸義人、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 食道癌における Leucine-Rich Repeat-Containing protein 8A（LRRC8A）発現の臨床的意義について (2018)
  • Author(s): 小西智規、塩﨑敦、工藤道弘、庄田勝俊、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 胃癌細胞における低温刺激がもたらすRegulatory Volume Decrease (RVD) への影響． (2018)
  • Author(s): 満田雅人、塩﨑敦、山里有三、小菅敏幸、庄田勝俊、小西博貴、窪田健、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] Functional analysis and prognostic value of sodium iodide symporter (NIS) in gastric cancer (2018)
  • Author(s): Atsushi Shiozaki, Yosuke Ariyoshi, Toshiyuki Kosuga, Michihiro Kudou, Katsutoshi Shoda, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Yoshinori Marunaka, Eigo Otsuji
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] 胃癌におけるsodium iodide symporter(NIS)の機能とその臨床病理学的意義． (2017)
  • Author(s): 有吉要輔、塩﨑敦、市川大輔、有田智洋、小菅敏幸、小西博貴、森村玲、小松周平、生駒久視、栗生宜明、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾．
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 肝癌における温熱刺激によるAquaporin5制御を介した抗腫瘍効果． (2017)
  • Author(s): 小菅敏幸、塩﨑敦、工藤道弘、清水浩紀、市川大輔、小松周平、小西博貴、有田智洋、森村玲、村山康利、栗生宜明、生駒久視、中西正芳、岡本和真、藤原斉、大辻英吾．
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 食道癌におけるanion exchanger 1(AE1)の発現と役割． (2017)
  • Author(s): 小西智規、塩﨑敦、工藤道弘、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、小松周平、栗生宜明、生駒久視、中西正芳、市川大輔、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるCLIC1（Chloride Intracellular Channel-1）発現の意義． (2017)
  • Author(s): 小林利行、塩﨑敦、市川大輔、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、小松周平、栗生宜明、生駒久視、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾．
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるAquaporin1発現の臨床病理学的意義． (2017)
  • Author(s): 山里有三、塩﨑敦、市川大輔、小西智規、小林利行、有吉要輔、樋上翔一郎、工藤道弘、庄田勝俊、有田智洋、小西博貴、小菅敏幸、森村玲、村山康利、小松周平、栗生宜明、生駒久視、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 落合登志哉, 井上博之, 中辻拡興, 渡邉信之, 吉山敦, 伊藤博士, 當麻敦史, 中村憲司, 森村玲, 生駒久視, 大辻英吾 (2017)
  • Author(s): 高齢者(80歳以上)肝細胞癌切除例に対するリスク評価
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 当院における高齢者胆道癌症例の個別化切除療法 (2017)
  • Author(s): 落合登志哉, 井上博之, 中辻拡興, 吉山敦, 渡邉信之, 伊藤博士, 當麻敦史, 中村憲司, 大辻英吾
  • Organizer: 第72回日本消化器外科学会総会
• [Presentation] 食道癌におけるsodium iodide symporterの発現とその意義 (2017)
  • Author(s): 有吉要輔、塩﨑敦、市川大輔、飯高大介、小菅敏幸、小西博貴、窪田健、藤原斉、岡本和真、岸本光夫、丸中良典、大辻英吾．
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 食道扁平上皮癌におけるAnion Exchanger 2の発現・機能解析 (2017)
  • Author(s): 塩﨑敦、樋上翔一郎、小菅敏幸、庄田勝俊、有田智洋、小西博貴、小松周平、窪田健、藤原斉、岡本和真、岸本光夫、丸中良典、大辻英吾．
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 食道扁平上皮癌におけるCLIC1(Chloride Intracellular Channel-1)の発現と役割 (2017)
  • Author(s): 小林利行、塩﨑敦、小菅敏幸、名幸義人、工藤道弘、庄田勝俊、有田智洋、小西博貴、窪田健、藤原斉、岡本和真、岸本光夫、大辻英吾．
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 胃癌におけるNISの発現と機能 (2017)
  • Author(s): 小西智規、塩﨑敦、有吉要輔、飯高大輔、小菅敏幸、小西博貴、窪田健、藤原斉、岡本和真、岸本光夫、丸中良典、大辻英吾．
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 食道癌幹細胞のイオン輸送体を標的とした治療法の開発 (2017)
  • Author(s): 工藤道弘、塩﨑敦、小菅敏幸、有田智洋、庄田勝俊、中西正芳、栗生宜明、窪田健、中西正芳、藤原斉、岡本和真、丸中良典、大辻英吾．
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 食道扁平上皮癌におけるAquaporin1の発現と予後との検討 (2017)
  • Author(s): 山里有三、塩﨑敦、有田智洋、小菅敏幸、小西博貴、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾．
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 胃癌におけるカリウムイオン輸送遮断による低浸透圧殺細胞増強効果 (2017)
  • Author(s): 小菅敏幸、塩﨑敦、工藤道弘、山里有三、小松周平、小西博貴、有田智洋、村山康利、窪田健、岡本和真、藤原斉、中西正芳、大辻英吾．
  • Organizer: 第76回日本癌学会学術総会