Identification of a small compound targeting cancer stem cells in cholangiocarcinoma
| Project/Area Number |
17K10716
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Miyagi Prefectural Hospital Organization Miyagi Cancer Center |
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Principal Investigator |
Yamamoto Kuniharu 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 特任研究員 (00375073)
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| Co-Investigator(Kenkyū-buntansha) |
玉井 恵一 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 (40509262)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 胆管癌 / がん幹細胞 |
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| Outline of Final Research Achievements |
Recently, Cancer stem cell is recognized as therapy-resistant cells because its population is dominant in quiescent phase. We searched a new cancer stem cell-related gene, and found BEX2. BEX2 is indispensable in maintaining dormant cancer stem cells and could be a promising therapeutic target.
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| Academic Significance and Societal Importance of the Research Achievements |
私たちは難治性癌である胆管癌の新たな治療標的を同定した。今後、詳細な分子機構を明らかにすることで、新規治療に結びつく可能性がある。
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Report
(5 results)
Research Products
(3 results)
