Vasa Vasorum in Abdominal Aortic Aneurysm

• Project/Area Number: 17K10751
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: TANAKA Hiroki 浜松医科大学, 医学部, 特任研究員 (50456563)
• Co-Investigator(Kenkyū-buntansha): 鈴木 優子 浜松医科大学, 医学部, 准教授 (20345812) ; 浦野 哲盟 浜松医科大学, 医学部, 教授 (50193967) ; 佐野 秀人 浜松医科大学, 医学部, 助教 (80623842)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 腹部大動脈瘤 / 大動脈瘤 / モデル動物 / 生体イメージング / 心臓血管外科学 / 大血管外科学

Outline of Final Research Achievements

Abdominal aortic aneurysm (AAA) is an inflammatory cardiovascular disease common among the elderly,1, 2) and whose pathogenesis is not fully understood.We sought to determine whether hypoperfusion of the adventitial VV could develop AAA.In this study, we can observed inflammatory cell and hypoxia in AAA tissue by two-photon microscopy.

Academic Significance and Societal Importance of the Research Achievements

血管壁を栄養する微細な血流が腹部大動脈瘤(AAA)の発症や進展に関与することをより強く立証した。現況ではAAAの進展を制御する薬物療法はないが、微細な組織の血流改善が薬物の開発（あるいは治療適応の拡大）が新たな治療ターゲットになる。

Research Products

• [Journal Article] Pathological Implication of Adipocytes in AAA Development and the Rupture (2018)
  • Author(s): Kugo Hirona、Tanaka Hiroki、Moriyama Tatsuya、Zaima Nobuhiro
  • Journal Title: Annals of Vascular Diseases Volume: 11 Issue: 2 Pages: 159-168
  • DOI: 10.3400/avd.ra.17-00130
  • NAID: 130007410749
  • ISSN: 1881-641X, 1881-6428
  • Year and Date: 2018-06-25
  • Peer Reviewed
• [Journal Article] Proprotein Convertase Subtilisin/Kexin Type 9 Is Associated with Degenerating Adipocytes in Abdominal Aortic Aneurysm (2018)
  • Author(s): Tanaka Hiroki、Inuzuka Kazunori、Iida Yasunori、Shimizu Hideyuki、Unno Naoki、Urano Tetsumei
  • Journal Title: Journal of Oleo Science Volume: 67 Issue: 10 Pages: 1355-1360
  • DOI: 10.5650/jos.ess18131
  • NAID: 130007497383
  • ISSN: 1345-8957, 1347-3352
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Problems and Perspectives of Abdominal Aortic Aneurysm Research (2018)
  • Author(s): Tanaka Hiroki
  • Journal Title: Current Drug Targets Volume: 19 Issue: 11 Pages: 1227-1227
  • DOI: 10.2174/138945011911180720122330
• [Journal Article] Hypoperfusion of the aortic wall secondary to degeneration of adventitial vasa vasorum causes abdominal aortic aneurysms (2018)
  • Author(s): Tanaka Hiroki、Unno Naoki、Suzuki Yuko、Sano Hideto、Yata Tatsuro、Urano Tetsumei
  • Journal Title: Current Drug Targets Volume: 19 Issue: 11 Pages: 1327-1332
  • DOI: 10.2174/1389450119666180122154409
  • Peer Reviewed
• [Journal Article] Elevated Plasma Levels of LDL Cholesterol Promote Dissecting Thoracic Aortic Aneurysms in Angiotensin II-Induced Mice. (2018)
  • Author(s): Tanaka H, Iida Y, Iwaki T, Suzuki Y, Sano H, Miyajima C, Zaima N, Sasaki T, Sumioka A, Hakamata S, Shimizu H, Umemura K, Urano T.
  • Journal Title: Ann Vasc Surg. Volume: 48 Pages: 204-213
  • DOI: 10.1016/j.avsg.2017.10.006
  • Peer Reviewed
• [Journal Article] PC194 Ectopic Expression of Proprotein Convertase Subtilisin Kexin Type 9 by Smooth Muscular Cells Contributes to Aortic Dissection. (2017)
  • Author(s): Iida Y, Tanaka H, Urano T, Unno N, Shimizu H.
  • Journal Title: J Vasc Surg Volume: 65(6) Pages: 195-203
  • DOI: 10.1016/j.avsg.2017.10.005
  • Peer Reviewed