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Development of Forecasting Technology for Onset of Aortic Dissection using X-ray Phase-contrast Tomography and Vascular Ultrasonography

Research Project

Project/Area Number 17K10754
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionKobe University

Principal Investigator

TSUKUBE Takuro  神戸大学, 医学研究科, 非常勤講師 (50304100)

Co-Investigator(Kenkyū-buntansha) 中川 和憲  九州大学, 医学研究院, 講師 (50217668)
八木 直人  公益財団法人高輝度光科学研究センター, 分光・イメージング推進室, 特別研究員 (80133940)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords急性大動脈解離 / 放射光位相差X線CT法 / 高周波超音波法 / 発症前診断 / 位相差X線CT法 / 超音波イメージング / 位相差エック線 / 超音波診断 / 大動脈壁構造研究 / SPring-8 / 発症機序の解明 / 大動脈解離 / 位相差エックス線CT法 / 大動脈瘤 / 予防医学
Outline of Final Research Achievements

We applied synchrotron-based X-ray phase tomography (XPCT) to 14 human aortic specimens of acute aortic dissection(AADA) and divided into two groups; formalin-fixed (Group-A: n=7) or fresh (Group-F: n=7) and densities of tunica media (DTM) were measured. To investigate the dynamic phenomena under stretching, dynamic X-ray phase tomography (dynamic-XPCT) were applied for Group-F. Theses XPCT findings were compared to high resolution aortic ultrasound imaging.
Synchrotron-based X-ray phase tomography had a capability to trace the detail of deformation process of the aortic wall, and these findings might be reflected in preclinical diagnosis of acute type A aortic dissection. Theses XPCT findings of aortic wall were compared to high resolution aortic ultrasound imaging.

Academic Significance and Societal Importance of the Research Achievements

大型放射光施設施設の位相差X 線CT 法を利用し、大動脈疾患の異常血管構造解析を非破壊で生体内環境に近い条件で行い、中膜の異常構造をCT像として可視化しえた。その主な学術的意義として2019年に国際ワークショップで成果を講演し、将来の国際共同研究に繋がった。さらに放射光位相差X線CT法で大動脈中膜疾患(大動脈解離など)の壁構造異常が明らかにされ、さらに得られた中膜構造の変化が高周波超音波大動脈検査法で再現しえた。社会的意義として、妥当性・有用性が証明された事で、今後の超音波プローべ開発に寄与し、致死的な大動脈疾患に特異的な血管構造異常の解析・検出が一気に進展し治療・予防に直結すると期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report

Research Products

(6 results)

All 2019 2018 2017

All Presentation (6 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results)

  • [Presentation] Cardiovascular imaging at SPring-82019

    • Author(s)
      Takuro Tsukube
    • Organizer
      1st International Workshop for Cardiovascular X-ray Phase-Contrast Imaging
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synchrotron-based 4D-X-ray phase tomography of fresh aortic wall of acute aortic dissection2019

    • Author(s)
      Takuro Tsukube, Koki Yokawa, Naoto Yagi, Masato Hoshino, Yutaka Nakashima, Kazunori Nakagawa
    • Organizer
      2019 Annual Meeting of American Heart Association
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cardiovascular imaging at SPring-82019

    • Author(s)
      Takuro Tsukube
    • Organizer
      1st International Workshop Cardiovascular X-ray Phase-Contrast Imaging
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Mechanism of Aneurysm Expansion After Endovascular Aortic Repair Analyzed With X-Ray Phase-Contrast Tomography2018

    • Author(s)
      Takateru Yamamoto, Kenji Okada,Naoto Yagi, Masato Hoshino, Yutaka Nakashima, Kazunori Nakagawa, Takuro Tsukube
    • Organizer
      2018 Annual Meeting of American Heart Association
    • Related Report
      2018 Research-status Report
  • [Presentation] Quantitative and Dynamic Measurements of Fresh Aortic Wall of Acute Type-A Aortic Dissection with X-ray Phase-contrast Tomography2017

    • Author(s)
      Koki Yokawa, Takuro Tsukube, Naoto Yagi, Masato Hoshino, Yutaka Nakashima, Kazunori Nakagawa, Yutaka Okita
    • Organizer
      31th Annual Meeting of the European Association for Cardiothoracic Surgeones
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Degeneration of tunica media in acute type-A aortic dissection from X-ray phase-contrast tomography2017

    • Author(s)
      Koki Yokawa, Takuro Tsukube, Naoto Yagi, Masato Hoshino, Yutaka Nakashima, Kazunori Nakagawa, Yutaka Okita
    • Organizer
      2017 Annual Meeting of American Heart Association
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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