Establishment of prophylactic treatment for aortic disease form analyzing the mechanism of aortic aneurysmal formation and aortic dissection
| Project/Area Number |
17K10761
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
益田 宗孝 横浜市立大学, 医学研究科, 教授 (10190365)
内田 敬二 横浜市立大学, 附属市民総合医療センター, 診療教授 (50275062)
横山 詩子 東京医科大学, 医学部, 主任教授 (70404994)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 大動脈瘤 / プロスタグランジンE2 / アンギオテンシンII / calcium chloride / オーダーメイド医療 |
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| Outline of Final Research Achievements |
No effective pharmacological therapy to attenuate AAA progression is currently available. We reported that the prostaglandin E receptor EP4 plays roles in AAA progression.
Here, we show the effect of CJ-42794, a selective EP4 antagonist, on AAA using two mouse models (angiotensin II- and CaCl2-induced AAAs) . CJ-42794 prevented aneurysmal formation of the two mouse models.
Additionally, in smooth muscle cells isolated from human AAA tissues, stimulation of CJ-42794 inhibited PGE2-induced IL-6 secretion in a dose-dependent manner and decreased PGE2-induced MMP-2 activity. These data suggest that inhibition of EP4 has the potential to be a pharmacological strategy for attenuation of AAA progression.
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| Academic Significance and Societal Importance of the Research Achievements |
大動脈疾患の患者数は年々増加しており生命にかかわる重症疾患である。大動脈瘤化や大動脈解離発症のメカニズムの解明や、予防法や早期介入を含めた治療法の確立は、医学的に大きな意義がある。
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] A selective antagonist of prostaglandin E receptor subtype 4 attenuate abdominal aortic aneurysm2018
Author(s)
Mamun A, Yokoyama U, Saito J, Ito S, Hiromi T, Umemura M, Fujita T, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Masuda M, Ishikawa Y
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Journal Title
Physiological Reports
Volume: 18
Related Report
Peer Reviewed / Open Access
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[Journal Article] Proteomic analysis of aortic smooth muscle cell secretions reveals an association of myosin heavy chain 11 with abdominal aortic aneurysm2018
Author(s)
Yokoyama U, Arakawa N, Ishikawa R, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, MatsumotoM, Koizumi N, Taguri M, Hirano H, Yoshimura K, Ogino H, Masuda M, Ishikawa Y
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Journal Title
Am J Physiol Heart Circ Physiol
Volume: 315
Related Report
Peer Reviewed / Open Access
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