Effect of insulin on platelet aggregation in coronary artery bypass grafting
| Project/Area Number |
17K10771
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cardiovascular surgery
|
|---|
| Research Institution | Kyushu University of Health and Welfare |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
蒲生 修治 九州保健福祉大学, 薬学部, 教授 (20273930)
|
|---|
| Project Period (FY) |
2017-04-01 – 2022-03-31
|
| Project Status |
Completed (Fiscal Year 2021)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 冠動脈バイパス手術 / 糖尿病 / 血小板 / インスリン / 伏在静脈 / スパズム / セロトニン（5-HT） / セロトニン / 血小板凝集 / 心バイパス手術 |
|---|
| Outline of Final Research Achievements |
It is likely that the increased contractile response to serotonin (5-HT) found in the blood vessels of diabetic patients may be due to the relative increase in the number of 5-HT2A receptors in the vascular smooth muscle cell membrane by the deficiency of insulin. The inhibitory effect of insulin on platelet aggregation induced by 5-HT was confirmed in rabbit platelets. However, in human platelets, the inhibitory effect of insulin on platelet aggregation induced by 5-HT was not confirmed. Platelet aggregation by 5-HT stimulation was observed after collagen stimulation, and its action was confirmed to be much smaller than that of ADP, which is another platelet-derived substance. Therefore, it is likely that the enhanced vasoconstrictor responsiveness to 5-HT observed in the blood vessels of diabetic patients is limited to vasoconstrictor muscle cells, and the contribution of 5-HT alone stimulation to platelets is small.
|
| Academic Significance and Societal Importance of the Research Achievements |
我々はこれまで、糖尿病におけるグラフト血管れん縮の増大には、インスリンによる細胞膜からの5-HT2A受容体インターナリゼーション作用の減弱が関連することを明らかにしてきた。しかし、この反応が血小板でも同様に起こるかは分かっていない。現在、周術期の血管れん縮抑制にはCa拮抗薬やアンジオテンシンⅡ受容体拮抗薬等が使用され、治療成績は改善されつつあるが、より有効で安全な予防法の確立が必要とされている。食生活の変化や高齢化社会の進展などにより、糖尿病患者に対する冠動脈バイパス手術施行回数が年々増加する中で、本研究の社会的意義は大きいと思われる。
|
Report
(6 results)
Research Products
(12 results)
-
-
[Journal Article] Effects of M-1, a Major Metabolite of Sarpogrelate, on 5-HT-Induced Constriction of Isolated Human Internal Thoracic Artery2020
Author(s)
Naoko Tanaka-Totoribe, Muneaki Hidaka, Shuji Gamoh, Atsuko Yokota, Eisaku Nakamura, Masachika Kuwabara, Jun Tsunezumi, Ryuichi Yamamoto
-
Journal Title
Biological and Pharmaceutical Bulletin
Volume: 43
Issue: 12
Pages: 1979-1982
DOI
NAID
ISSN
0918-6158, 1347-5215
Year and Date
2020-12-01
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
[Presentation] In patients with diabetes mellitus(DM), but not in patients without DM, angiotensin II is a vasospasm inducer in both venous and arterial conduits under coronary artery bypass grafting2018
Author(s)
Tatsuo Shiba, Atsuko Yokota, Shuji Gamoh, Naoko Tanaka-Totoribe, Masachika Kuwabara, Eisaku Nakamura, Takairo Hayase, Kunihide Nakamura, Hiroaki Hisa, Ryuichi Yamamto
Organizer
18th WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY(国際学会)
Related Report
Int'l Joint Research
-
-
