| Project/Area Number |
17K10826
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
甲村 英二 神戸大学, 医学研究科, 名誉教授 (30225388)
林 公祐 神戸大学, 工学研究科, 准教授 (60455152)
細田 弘吉 神戸大学, 医学研究科, 医学研究員 (90403261)
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | cerebral aneurysm / CFD / WSS / OSI / growing / rupture / prediction / growth / thick wall / thin wall / thin walled region / aneurysm growth / high / simulation |
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| Outline of Final Research Achievements |
In this study, we have developed a CFD analysis software that can perform CFD analysis from MRA only, in collaboration with the Faculty of Engineering at Kobe University. We evaluated the validity of this analysis method by conducting flow experiments in a simulated vascular channel using a silicon resin cerebral aneurysm model to see if the method reflects the actual parameters (2 papers). We found that aneurysms having a transient increase region of wall shear stress in the early stage of dilation during one cardiac cycle tended to increase in size afterwards (1 paper). In addition, we found that WSS vector cycle variation (WSSVV) and oscillatory shear index (OSI) can predict aneurysm wall thinness (3 papers).
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| Academic Significance and Societal Importance of the Research Achievements |
脳ドックでしばしば発見される未破裂脳動脈瘤の内、ここ数年のうちに増大・破裂をきたすのはわずかであるが、その特徴はこれまで不明であった。今回我々が発見したCFD解析のパラメーターを用いることで、近い将来増大を来たしうる動脈瘤、また破裂しやすいと言われる壁菲薄部を持つ動脈瘤を同定できるようになり、破裂予防手術を行っておくべき動脈瘤をより効率的に同定できるようになった。また本数値流体力学的特徴が及ぼす動脈瘤壁への組織学的影響を検索することで、脳動脈瘤の破裂メカニズム解明に寄与できる可能性がある。
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