| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In this study, we conducted experiments to express Ascl1, Sox2, and NeuroD1 in glial cells in the post-stroke brain of mice using retrovirus. As a result, it was revealed that neural progenitor cells were induced 24 days after the retrovirus injection and mature neurons were induced 52 days. These results suggested that nerve cells can be reproduced from the abundant remaining glial cells in the brain. In the future, we will further improve the induction efficiency, establish safety and promote the development of treatment methods that contribute to the improvement of motor paralysis in patients with ischemic stroke.
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