| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Lysophospholipids, which are physiologically active lipids, play important roles in immunity and the vascular system. In this study, we investigated the role of lysophospholipids, such as sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA), at the blood-brain barrier (BBB). Examination using the in vitro BBB model and the in vivo model revealed that S1P and LPA have an effect on regulating BBB function. Furthermore, we have found that inhibition of S1P signaling by sphingosine kinase inhibitor (SKI-II) or ABCA1 transporter inhibitor (Probucol) prevents BBB dysfunction after ischemia both in vitro and in vivo.
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