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Visualization of epileptogenesis by PET multi-tracer methods

Research Project

Project/Area Number 17K10886
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Inaji Motoki  東京医科歯科大学, 医学部附属病院, 講師 (00422486)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsepilepsy / PET / てんかん / てんかん原性
Outline of Final Research Achievements

PET evalustion with multi-tracers realize the determination of epliptic foci with high accuracy in clinical diagonsis. Because the epileptic foci was expressed as cold lesion, statistical analysis was required. TSPO is hopeful target for PET imaging. TSPO PET iagung clearly visualized the foci in the basic research. Glutamate receptor type5, tryptophan metabolism are also hopeful target for imaging. Actually, significant increasing binding was observed in each model animals. Especially in EL mice, uptake into whole brain by tryptophan metabolism is markedly increased, and it is considered to be the most useful PET tracer for clinical application. This metabolism does not change in the lesion related epilepsy model.

Academic Significance and Societal Importance of the Research Achievements

てんかん外科ではてんかん焦点を切除することで根治が期待できるが、てんかん焦点の明確なイメージングはいまだ困難である。PET、SPECTといった核医学検査は、構造的な異常ではなく、質的な脳機能異常を可視化しうる。また、複数のリガンドを用いることで脳機能を多角的に評価することができ、てんかん原性により本質的な焦点の可視化が期待される。さらには、基礎動物実験からヒト臨床までの共通した診断ツールでもある。てんかん焦点診断のみならず、てんかん原性の機序解明に寄与しうる可能性を持っており、さらなる新規トレーサー開発による本質的な焦点診断が期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (42 results)

All 2020 2019 2018 2017

All Journal Article (18 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 15 results,  Open Access: 7 results,  Acknowledgement Compliant: 1 results) Presentation (23 results) (of which Int'l Joint Research: 9 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] Detection of hemodynamic impairment on 15O gas PET using visual assessment of arterial spin-labeling MR imaging in patients with moyamoya disease2020

    • Author(s)
      Hara Shoko、Tanaka Yoji、Ueda Yasuhiro、Abe Daisu、Hayashi Shihori、Inaji Motoki、Maehara Taketoshi、Ishii Kenji、Nariai Tadashi
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 72 Pages: 258-263

    • DOI

      10.1016/j.jocn.2019.11.026

    • Related Report
      2019 Annual Research Report
  • [Journal Article] テクニカル・ノート 遠位部前大脳動脈瘤の部位,親動脈を同定するためのカラードップラーエコーの有用性2019

    • Author(s)
      澤栁 文菜、前原 健寿、壽美田 一貴、田中 洋次、唐鎌 淳、工藤 琢巳、田村 郁、菅原 貴志、稲次 基希、成相 直
    • Journal Title

      Neurological Surgery 脳神経外科

      Volume: 47 Issue: 3 Pages: 321-327

    • DOI

      10.11477/mf.1436203937

    • ISSN
      0301-2603, 1882-1251
    • Year and Date
      2019-03-10
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Journal Article] Regression of White Matter Hyperintensity after Indirect Bypass Surgery in a Patient with Moyamoya Disease2019

    • Author(s)
      Hara S, Hori M, Inaji M, Maehara T, Aoki S, Nariai T
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 18 Issue: 4 Pages: 247-248

    • DOI

      10.2463/mrms.ci.2018-0088

    • NAID

      130007728806

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unraveling Specific Brain Microstructural Damage in Moyamoya Disease Using Diffusion Magnetic Resonance Imaging and Positron Emission Tomography.2019

    • Author(s)
      Hara S, Hori M, Ueda R, Hayashi S, Inaji M, Tanaka Y, Maehara T, Ishii K, Aoki S, Nariai T
    • Journal Title

      Journal of Stroke and Cerebrovascular diseases

      Volume: 28 Issue: 4 Pages: 1113-1125

    • DOI

      10.1016/j.jstrokecerebrovasdis.2018.12.038

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of [<sup>11</sup>C] Methionine PET in the Differentiation of Tumefactive Multiple Sclerosis from High Grade Astrocytoma2019

    • Author(s)
      HASHIMOTO Satoka、INAJI Motoki、NARIAI Tadashi、KOBAYASHI Daisuke、SANJO Nobuo、YOKOTA Takanori、ISHII Kenji、TAKETOSHI Maehara
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 59 Issue: 5 Pages: 176-183

    • DOI

      10.2176/nmc.oa.2018-0287

    • NAID

      130007649853

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Journal Article] Intravoxel incoherent motion perfusion in patients with Moyamoya disease: comparison with 15O-gas positron emission tomography2019

    • Author(s)
      Hara Shoko、Hori Masaaki、Ueda Ryo、Hagiwara Akifumi、Hayashi Shihori、Inaji Motoki、Tanaka Yoji、Maehara Taketoshi、Ishii Kenji、Aoki Shigeki、Nariai Tadashi
    • Journal Title

      Acta Radiologica Open

      Volume: 8 Issue: 5 Pages: 1-1

    • DOI

      10.1177/2058460119846587

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of a collaborative transdisciplinary team approach on oral health status in acute stroke patients2019

    • Author(s)
      Obana Michiyo、Furuya Junichi、Matsubara Chiaki、Tohara Haruka、Inaji Motoki、Miki Kazunori、Numasawa Yoshiyuki、Minakuchi Shunsuke、Maehara Taketoshi
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 46 Issue: 12 Pages: 1170-1176

    • DOI

      10.1111/joor.12855

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bayesian Estimation of CBF Measured by DSC-MRI in Patients with Moyamoya Disease: Comparison with 15O-Gas PET and Singular Value Decomposition2019

    • Author(s)
      Hara S.、Tanaka Y.、Hayashi S.、Inaji M.、Maehara T.、Hori M.、Aoki S.、Ishii K.、Nariai T.
    • Journal Title

      American Journal of Neuroradiology

      Volume: 40 Pages: 1894-1900

    • DOI

      10.3174/ajnr.a6248

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness of perampanel as a first add-on antiepileptic drug for the treatment of partial epilepsy.2019

    • Author(s)
      Takahashi S, Shimizu K, Inaji M, Hashimoto S, Yamamoto S, Maehara T
    • Journal Title

      Epilepsy Behav.

      Volume: 100 Pages: 106492-106492

    • DOI

      10.1016/j.yebeh.2019.106492

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 連載 機能的脳神経外科最新の動向 (3)難治性てんかんに対する発作感知型デバイスによる新たな治療選択肢-AspireSR & RNS System2018

    • Author(s)
      山本 貴道、稲次 基希、前原 健寿、川合 謙介、Werner K. Doyle
    • Journal Title

      Neurological Surgery 脳神経外科

      Volume: 46 Issue: 3 Pages: 247-262

    • DOI

      10.11477/mf.1436203711

    • ISSN
      0301-2603, 1882-1251
    • Year and Date
      2018-03-10
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Microstructural Damage in Normal-Appearing Brain Parenchyma and Neurocognitive Dysfunction in Adult Moyamoya Disease2018

    • Author(s)
      Hara Shoko、Hori Masaaki、Murata Syo、Ueda Ryo、Tanaka Yoji、Inaji Motoki、Maehara Taketoshi、Aoki Shigeki、Nariai Tadashi
    • Journal Title

      Stroke

      Volume: 49 Issue: 10 Pages: 2504-2507

    • DOI

      10.1161/strokeaha.118.022367

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unique Angiographic Appearances of Moyamoya Disease Detected with 3-Dimensional Rotational Digital Subtraction Angiography Imaging Showing the Hemodynamic Status2018

    • Author(s)
      Karakama Jun、Nariai Tadashi、Hara Shoko、Hayashi Shihori、Sumita Kazutaka、Inaji Motoki、Tanaka Yoji、Wagatsuma Kei、Ishii Kenji、Nemoto Shigeru、Maehara Taketoshi
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 27 Issue: 8 Pages: 2147-2157

    • DOI

      10.1016/j.jstrokecerebrovasdis.2018.03.006

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased Binding Potential of Brain Adenosine A1 Receptor in Chronic Stages of Patients with Diffuse Axonal Injury Measured with [1-methyl-11C] 8-dicyclopropylmethyl-1-methyl-3-propylxanthine Positron Emission Tomography Imaging2018

    • Author(s)
      Hayashi Shihori、Inaji Motoki、Nariai Tadashi、Oda Keiichi、Sakata Muneyuki、Toyohara Jun、Ishii Kenji、Ishiwata Kiichi、Maehara Taketoshi
    • Journal Title

      Journal of Neurotrauma

      Volume: 35 Issue: 1 Pages: 25-31

    • DOI

      10.1089/neu.2017.5006

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Noninvasive Evaluation of CBF and Perfusion Delay of Moyamoya Disease Using Arterial Spin-Labeling MRI with Multiple Postlabeling Delays: Comparison with 15O-Gas PET and DSC-MRI.2017

    • Author(s)
      Hara S, Tanaka Y, Ueda Y, Hayashi S, Inaji M, Ishiwata K, Ishii K, Maehara T, Nariai T.
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: 38 Issue: 4 Pages: 696-702

    • DOI

      10.3174/ajnr.a5068

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Amelioration of intractable epilepsy by adjunct vagus nerve stimulation therapy in a girl with a CDKL5 mutation2017

    • Author(s)
      Baba Shimpei、Sugawara Yuji、Moriyama Kengo、Inaji Motoki、Maehara Taketoshi、Yamamoto Toshiyuki、Morio Tomohiro
    • Journal Title

      Brain and Development

      Volume: 39 Issue: 4 Pages: 341-344

    • DOI

      10.1016/j.braindev.2016.10.007

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case of Familial Moyamoya Disease Presenting 10 Years After Initial Negative Magnetic Resonance Screening in Childhood2017

    • Author(s)
      Aoyama Jiro、Nariai Tadashi、Mukawa Maki、Inaji Motoki、Tanaka Yoji、Maehara Taketoshi
    • Journal Title

      World Neurosurgery

      Volume: 105 Pages: 1035.e1-1035.e4

    • DOI

      10.1016/j.wneu.2017.06.036

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of a novel tungsten-impregnated rubber neck shield on the quality of cerebral images acquired using 15O-labeled gas2017

    • Author(s)
      Wagatsuma Kei、Oda Keiichi、Miwa Kenta、Inaji Motoki、Sakata Muneyuki、Toyohara Jun、Ishiwata Kiichi、Sasaki Masayuki、Ishii Kenji
    • Journal Title

      Radiological Physics and Technology

      Volume: 10 Issue: 4 Pages: 422-430

    • DOI

      10.1007/s12194-017-0414-5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation between Clinical Presentations and Hemodynamic Parameters Measured by Dynamic Susceptibility Contrast Magnetic Resonance Imaging in Adult Patients with Moyamoya Disease2017

    • Author(s)
      Hirai Sakyo、Inaji Motoki、Tanaka Yoji、Hara Shoko、Nariai Tadashi、Maehara Taketoshi
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 26 Issue: 12 Pages: 2814-2820

    • DOI

      10.1016/j.jstrokecerebrovasdis.2017.06.057

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Astrocyte dysfunction induced by abnormal tryptophan metabolism in the pathology of epilepsy.2019

    • Author(s)
      Hashimoto S , Maeda J , Takuwa H , Takado Y , Shimojo M , Takahashi M , Urushihata T , Sampei K , Minamihisamatsu T , Inaji M , Kumata K , Ming-Rong Z , Suhara T , Maehara T
    • Organizer
      the 33rd International Epilepsy Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Perampanel administration as an add-on therapy in patients with partial seizures2019

    • Author(s)
      Thamamongood I, Takahashi S, Hashimoto S, Inaji M, Yamamoto S, Maehara T.
    • Organizer
      the 33rd International Epilepsy Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] [11C] MPDX PET imaging of adenosine A1 receptors in mesial temporal lobe epilepsy patients2019

    • Author(s)
      Inaji M, Hayashi S, Nariai T, Sakata M, Ishii K, Maehara T.
    • Organizer
      the 33rd International Epilepsy Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Changes in cerebral blood flow during pregnancy detected by arterial spin labeling MRI in healthy subjects and in the patients with moyamoya disease.2019

    • Author(s)
      Tanaka Y, Miyasaka N, Hara S, Inaji M, Maehara T, Nariai T.
    • Organizer
      BRAIN and BRAIN PET 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Insights into the improvement of neurocognitive dysfunction after indirect bypass surgery in adult Moyamoya disease; 15O-gas positron emission tomography study.2019

    • Author(s)
      Hara S, Kudo T, Hayashi S, Inaji M, Maehara T, Ishii K, Nariai T.
    • Organizer
      BRAIN and BRAIN PET 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Postoperative anti-epileptic drugs of patients treated by hippocampal transection.2019

    • Author(s)
      Taketoshi Maehara, Motoki Inaji, Satoka Hashimoto, Asumi Orihara
    • Organizer
      The 13th Asian Epilepsy Surgery Congress (AESC2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The difference of metabolism and neuroinflammation between epileptic animal models.2019

    • Author(s)
      S.Hashimoto, J.Maeda, M.Inaji, K.Kumata, M.Chang, T.Maehara, M.Higuchi.
    • Organizer
      AES2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Views of patients with epilepsy on wearable seizure prediction system; Impact of two different type of devices on sleep quality.2019

    • Author(s)
      Miyajima M, Yamakawa T, Fujiwara K, Seki T, Ohno T, IimoriM, Inaji M, Osoegawa H, Kano M, Maehara T.
    • Organizer
      World sleep 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New York UniversityにおけるResponsive Neurostimulation2018

    • Author(s)
      稲次基希、山本貴道、川合謙介、前原健寿、Werner Doyle
    • Organizer
      第41回日本てんかん外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 海馬硬化を伴う内側側頭葉てんかん患者の海馬切除術前後の側頭葉外側皮質脳波変化2018

    • Author(s)
      永森千寿子、原恵子、赤座実穂、前原健寿、稲次基希、角勇樹
    • Organizer
      第41回日本てんかん外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] てんかん焦点診断における、[18F]FDGPET、[11C]flumazenil-PET SPM統計画像解析2018

    • Author(s)
      稲次基希、林志保理、我妻慧、豊原潤、石井賢二、成相直、前原健寿
    • Organizer
      第41回日本脳神経CI学会
    • Related Report
      2017 Research-status Report
  • [Presentation] てんかんの画像診断2018

    • Author(s)
      稲次基希
    • Organizer
      第41回日本てんかん外科学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] MST前後の術中脳波における高周波律動解析を行った一例2017

    • Author(s)
      永森千寿子、原恵子、太田克也、赤座実穂、前原健寿、稲次基希、角勇樹
    • Organizer
      第11回日本てんかん学会関東甲信越地方会
    • Related Report
      2017 Research-status Report
  • [Presentation] Detection of Epileptogenic lesion using PET with multitracers.2017

    • Author(s)
      稲次基希、橋本聡華、林志保里、我妻慧、豊原潤、石井賢二、前田純、樋口真人、前原健寿
    • Organizer
      日本脳神経外科学会第76回学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 基礎と臨床の包括的研究の重要性2017

    • Author(s)
      前原健寿、橋本聡華、清水一秀、稲次基希、池田昭夫、柿田明美、井上有史、渡辺裕貴、岩崎真樹、白水洋史、福田敦夫、小泉修一、岡田元宏、大野行弘
    • Organizer
      第51回日本てんかん学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 新規PETトレーサーを用いた焦点診断の試み2017

    • Author(s)
      稲次基希、橋本聡華、石井賢二、豊原潤、前田純、樋口真人、前原健寿 新規PETトレーサーを用いた焦点診断の試み
    • Organizer
      第51回日本てんかん学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] モデルマウスを用いたトリプトファン代謝のてんかん病態への関与の検討2017

    • Author(s)
      橋本聡華、前田純、稲次基希、熊田勝志、張明栄、須原哲也、前原健寿、樋口真人
    • Organizer
      第51回日本てんかん学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 多施設共同研究における発作時DC電位・HFOの記録および解析の標準化案2017

    • Author(s)
      中谷光良、井内盛遠、十川純平、村井智彦、小林勝哉、人見健文、橋本聡華、稲次基希、白水洋史、金澤恭子、渡辺裕貴、臼井直敬、井上有史、前原健寿、池田昭夫
    • Organizer
      第51回日本てんかん学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] てんかんにおける核医学検査の現状-脳神経外科の立場から2017

    • Author(s)
      稲次基希、橋本聡華、林志保里、石井賢二、樋口真人、前原健寿
    • Organizer
      第47回日本臨床神経生理学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Altered tryptophan metabolism can accelerate epileptogenesis2017

    • Author(s)
      Hashimoto,S., Maeda,J., Kumata,K., Takado,Y., Inaji,M., Ming-Rong Zhang, Suhara,T., Maehara,T., Higuchi,M.
    • Organizer
      American Epilpsy Society Annual Meeting 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] HFO検出ソフト2種類を用いた発作時脳波解析結果の比較2017

    • Author(s)
      吉村優里、原恵子、赤座実穂、稲次基希、永森千寿子、橋本聡華、太田克也、角勇樹、前原健寿
    • Organizer
      第47回日本臨床神経生理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] EMUにおける医師の役割2017

    • Author(s)
      稲次基希、原恵子、前原健寿
    • Organizer
      第47回日本臨床神経生理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 多彩な発作型を呈した左側頭葉島皮質てんかんの一例2017

    • Author(s)
      橋本聡華、稲次基希、原恵子、前原健寿
    • Organizer
      第47回日本臨床神経生理学会
    • Related Report
      2017 Research-status Report
  • [Book] てんかんの薬物治療 ③頻用される新規約 ブレインナーシング 第33巻12号2017

    • Author(s)
      稲次基希、原田裕美
    • Total Pages
      5
    • Publisher
      メディカ出版
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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