Visualization of epileptogenesis by PET multi-tracer methods
| Project/Area Number |
17K10886
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Inaji Motoki 東京医科歯科大学, 医学部附属病院, 講師 (00422486)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | epilepsy / PET / てんかん / てんかん原性 |
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| Outline of Final Research Achievements |
PET evalustion with multi-tracers realize the determination of epliptic foci with high accuracy in clinical diagonsis. Because the epileptic foci was expressed as cold lesion, statistical analysis was required. TSPO is hopeful target for PET imaging. TSPO PET iagung clearly visualized the foci in the basic research. Glutamate receptor type5, tryptophan metabolism are also hopeful target for imaging. Actually, significant increasing binding was observed in each model animals. Especially in EL mice, uptake into whole brain by tryptophan metabolism is markedly increased, and it is considered to be the most useful PET tracer for clinical application. This metabolism does not change in the lesion related epilepsy model.
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| Academic Significance and Societal Importance of the Research Achievements |
てんかん外科ではてんかん焦点を切除することで根治が期待できるが、てんかん焦点の明確なイメージングはいまだ困難である。PET、SPECTといった核医学検査は、構造的な異常ではなく、質的な脳機能異常を可視化しうる。また、複数のリガンドを用いることで脳機能を多角的に評価することができ、てんかん原性により本質的な焦点の可視化が期待される。さらには、基礎動物実験からヒト臨床までの共通した診断ツールでもある。てんかん焦点診断のみならず、てんかん原性の機序解明に寄与しうる可能性を持っており、さらなる新規トレーサー開発による本質的な焦点診断が期待される。
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Report
(4 results)
Research Products
(42 results)
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[Presentation] Astrocyte dysfunction induced by abnormal tryptophan metabolism in the pathology of epilepsy.2019
Author(s)
Hashimoto S , Maeda J , Takuwa H , Takado Y , Shimojo M , Takahashi M , Urushihata T , Sampei K , Minamihisamatsu T , Inaji M , Kumata K , Ming-Rong Z , Suhara T , Maehara T
Organizer
the 33rd International Epilepsy Congress
Related Report
Int'l Joint Research
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[Presentation] Altered tryptophan metabolism can accelerate epileptogenesis2017
Author(s)
Hashimoto,S., Maeda,J., Kumata,K., Takado,Y., Inaji,M., Ming-Rong Zhang, Suhara,T., Maehara,T., Higuchi,M.
Organizer
American Epilpsy Society Annual Meeting 2017
Related Report
Int'l Joint Research
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