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Connectome map for epilepsy surgery originated by network imaging analysis and its justification by stereotactic electroencephalography (SEEG)

Research Project

Project/Area Number 17K10890
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionNagoya University

Principal Investigator

Maesawa Satoshi  名古屋大学, 脳とこころの研究センター, 特任教授 (90566960)

Co-Investigator(Kenkyū-buntansha) Bagarinao E.  名古屋大学, 脳とこころの研究センター, 特任准教授 (00443218)
渡辺 宏久  藤田医科大学, 医学部, 教授 (10378177)
寳珠山 稔  名古屋大学, 医学系研究科(保健), 教授 (30270482)
中坪 大輔  名古屋大学, 医学部附属病院, 病院准教授 (70378165)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords安静時fMRI / EEG-fMRI / MEG / SEEG / 焦点性てんかん / 焦点診断 / 脳内ネットワーク / focal epilepsy / epilepsy surgery / ネットワーク / 機能脳神経外科学
Outline of Final Research Achievements

The purpose of this study was to evaluate epileptogenic networks in focal epilepsy using novel modalities such as rsfMRI, MEG, and EEG-fMRI, create the connectome map, and justify with stereotactic electroencephalography (SEEG). Multilayer analysis with rsfMRI revealed epileptogenic hubs near the focus with excitatory connection to the contralateral hubs and inhibitory connections to the default mode network, and this may reflect pathological mechanism in focal epilepsy. Modified DS(distributed source) analysis in MEG and subsecond analysis in EEG-fMRI improved detection of epileptic focus and its networks. Novel metrics for demonstrating connectivity to canonical networks were created, and used as a connectome map. SEEG analyzed with coherence showed relationship between epileptic focus and its networks.

Academic Significance and Societal Importance of the Research Achievements

学術的意義としては、焦点性てんかんはネットワーク疾患である、という仮説に基づいてネットワーク的な解析を行う事で、てんかんの焦点、及び焦点より形成されるてんかん性ネットワークを明らかにした事が挙げられる。特に安静時fMRI、EEG-fMRI、MEGといったモダリティは非侵襲的であり、改良を加え新規解析を開発した点は、てんかん患者にとって非侵襲的で有効な検査法が増えた事となり、社会的意義が高い。SEEG(定位的頭蓋内電極による脳波記録)は海外で導入が始まっているが日本は遅れをとっており、その安全且つ有効な手法を確立し日本で最初に示し、更に脳波解析の可能性を示した点も意義がある。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (23 results)

All 2020 2019 2018 2017 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results,  Open Access: 8 results) Presentation (9 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] Subsecond EEG-fMRI analysis for presurgical evaluation in focal epilepsy2020

    • Author(s)
      Ito Yuji、Maesawa Satoshi、Bagarinao Epifanio、Okai Yu、Nakatsubo Daisuke、Yamamoto Hiroyuki、Kidokoro Hiroyuki、Usui Naotaka、Natsume Jun、Hoshiyama Minoru、Wakabayashi Toshihiko、Sobue Gen、Ozaki Norio
    • Journal Title

      Journal of Neurosurgery

      Volume: 13 Issue: 4 Pages: 1-10

    • DOI

      10.3171/2020.1.jns192567

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distributed source analysis of magnetoencephalography using a volume head model combined with statistical methods improves focus diagnosis in epilepsy surgery2020

    • Author(s)
      Ishizaki Tomotaka、Maesawa Satoshi、Nakatsubo Daisuke、Yamamoto Hiroyuki、Takai Sou、Shibata Masashi、Kato Sachiko、Natsume Jun、Hoshiyama Minoru、Wakabayashi Toshihiko
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 5263-5263

    • DOI

      10.1038/s41598-020-62098-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel non-invasive modalities for presurgical evaluation in focal epilepsy.2019

    • Author(s)
      Yuji Ito, Hiroyuki Yamamoto, Toru Okanishi, Satoshi Maesawa, Jun Natsume.
    • Journal Title

      Pediatr Int.

      Volume: 61 Issue: 3 Pages: 319-321

    • DOI

      10.1111/ped.13793

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reorganization of brain networks and its association with general cognitive performance over the adult lifespan.2019

    • Author(s)
      Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake,…他 Haruo Isoda, Shinji Naganawa, Gen Sobue
    • Journal Title

      Sci Rep.

      Volume: 9(1) Issue: 1 Pages: 11352-11352

    • DOI

      10.1038/s41598-019-47922-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anatomo-electro-clinical correlations of hypermotor seizures with amygdala enlargement: Hippocampal seizure origin identified using stereoelectroencephalography2019

    • Author(s)
      Ishizaki Tomotaka、Maesawa Satoshi、Nakatsubo Daisuke、Yamamoto Hiroyuki、Shibata Masashi、Kato Sachiko、Yoshida Mari、Natsume Jun、Hoshiyama Minoru、Wakabayashi Toshihiko
    • Journal Title

      Epilepsy & Behavior Case Reports

      Volume: 11 Pages: 10-13

    • DOI

      10.1016/j.ebcr.2018.09.011

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 連載 機能的脳神経外科最新の動向【新連載】 (1)EEG-fMRIを用いた焦点診断2018

    • Author(s)
      Maesawa S, Bagarinao E, Nakatsubo D, Wakabayashi T.
    • Journal Title

      Neurological Surgery 脳神経外科

      Volume: 46 Issue: 1 Pages: 67-79

    • DOI

      10.11477/mf.1436203677

    • ISSN
      0301-2603, 1882-1251
    • Year and Date
      2018-01-10
    • Related Report
      2017 Research-status Report
  • [Journal Article] An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan.2018

    • Author(s)
      Bagarinao E
    • Journal Title

      Neuroimage.

      Volume: 169 Pages: 134-144

    • DOI

      10.1016/j.neuroimage.2017.12.014

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Gradient Coil Noise and Gradient Coil Replacement on the Reproducibility of Resting State Networks2018

    • Author(s)
      Bagarinao Epifanio、Tsuzuki Erina、Yoshida Yukina、Ozawa Yohei、Kuzuya Maki、Otani Takashi、Koyama Shuji、Isoda Haruo、Watanabe Hirohisa、Maesawa Satoshi、Naganawa Shinji、Sobue Gen
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 12 Pages: 148-148

    • DOI

      10.3389/fnhum.2018.00148

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term Effect and Predictive Factors of Motor Cortex and Spinal Cord Stimulation for Chronic Neuropathic Pain2018

    • Author(s)
      TANEI Takafumi、KAJITA Yasukazu、MAESAWA Satoshi、NAKATSUBO Daisuke、AOKI Kosuke、NODA Hiroshi、TAKEBAYASHI Shigenori、NAKAHARA Norimoto、WAKABAYASHI Toshihiko
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 58 Issue: 10 Pages: 422-434

    • DOI

      10.2176/nmc.oa.2018-0106

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Application of Awake Surgery for Epilepsy in Clinical Practice2018

    • Author(s)
      MAESAWA Satoshi、NAKATSUBO Daisuke、FUJII Masazumi、IIJIMA Kentaro、KATO Sachiko、ISHIZAKI Tomotaka、SHIBATA Masashi、WAKABAYASHI Toshihiko
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 58 Issue: 10 Pages: 442-452

    • DOI

      10.2176/nmc.oa.2018-0122

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detecting sub-second changes in brain activation patterns during interictal epileptic spike using simultaneous EEG-fMRI2017

    • Author(s)
      Epifanio Bagarinao, Satoshi Maesawa, Yuji Ito, Naotaka Usui, Jun Natsume, Hirohisa Watanabe, Minoru Hoshiyama, Toshihiko Wakabayashi, Gen Sobue, Shinji Naganawa, Haruo Isoda
    • Journal Title

      Clin Neurophysiol.

      Volume: 129(2) Issue: 2 Pages: 377-389

    • DOI

      10.1016/j.clinph.2017.11.018

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Paroxysmal nonepileptic events in children with epilepsy.2017

    • Author(s)
      Ito Y, Kidokoro H, Negoro T, Tanaka M, Okai Y, Sakaguchi Y, Ogawa C, Takeuchi T, Ohno A, Yamamoto H, Nakata T, Maesawa S, Watanabe K, Takahashi Y, Natsume J
    • Journal Title

      Epilepsy Research

      Volume: 132 Pages: 59-63

    • DOI

      10.1016/j.eplepsyres.2017.02.009

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 安静時機能的MRIを使った複層的脳内大域ネットワーク解析とてんかん外科2019

    • Author(s)
      前澤聡、中坪大輔、加藤祥子、石崎友崇、柴田昌志、高井想生、若林俊彦
    • Organizer
      第78回 日本脳神経外科学会総会(大阪府大阪市)
    • Related Report
      2019 Annual Research Report
  • [Presentation] SEEGの臨床経験-日本の限られた設備の中での工夫2019

    • Author(s)
      前澤聡、中坪大輔、加藤祥子、石崎友崇、柴田昌志、高井想生、若林俊彦
    • Organizer
      第53回日本てんかん学会学術集会(兵庫県神戸市)
    • Related Report
      2019 Annual Research Report
  • [Presentation] てんかん外科における電気生理学的アプローチ2019

    • Author(s)
      前澤聡、中坪大輔、加藤祥子、石崎友崇、柴田昌志、高井想生、若林俊彦
    • Organizer
      第49回日本臨床神経生理学会(福島県福島市)
    • Related Report
      2019 Annual Research Report
  • [Presentation] SEEGと硬膜下電極併用による頭蓋内脳波記録と解析2018

    • Author(s)
      前澤 聡、中坪大輔、加藤祥子、石崎友崇、柴田昌志、高井想生、若林俊彦
    • Organizer
      第77回日本脳神経外科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] てんかんの新たな画像解析法 ―機能的MRI画像2018

    • Author(s)
      前澤 聡
    • Organizer
      第61回日本脳循環代謝学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] てんかんに対する最新のモダリティを使ったコネクトーム解析 - MRI, MEG, そしてEEG-fMRI2018

    • Author(s)
      前澤 聡
    • Organizer
      第52回日本てんかん学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 頭蓋内脳波記録におけるSEEGと硬膜下電極併用法の有用性2018

    • Author(s)
      前澤 聡、中坪大輔、加藤祥子、石崎友崇、柴田昌志、高井想生、若林俊彦
    • Organizer
      第42回日本てんかん外科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] SEEGにおけるロボットアームの有用性2017

    • Author(s)
      前澤 聡、中坪大輔、若林俊彦
    • Organizer
      第52回日本てんかん学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Hub analysis using resting state fMRI in patients with focal epilepsy and surgical outcomes2017

    • Author(s)
      Satoshi Maesawa, Bagarinao Epifanio, Daisuke Nakatsubo, Jun Natsume, Sachiko Kato, Tomoya Ishizaki, Masashi Shibata, Hirohisa Watanabe, Gen Sobue, Shinji Naganawa, Toshihiko Wakabayashi
    • Organizer
      71st annual meeting of American Epilepsy Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Remarks] 名古屋大学脳とこころの研究センター・実際の応用研究紹介・脳神経外科学

    • URL

      https://www.med.nagoya-u.ac.jp/noutokokoro/introduction/noushinkeigeka.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 名古屋大学 脳とこころの研究センター

    • URL

      https://www.med.nagoya-u.ac.jp/noutokokoro/

    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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