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Relationship between language and motor fibers in dominant side frontal lobe

Research Project

Project/Area Number 17K10892
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionKyoto University

Principal Investigator

Kikuchi Takayuki  京都大学, 医学研究科, 助教 (40625084)

Co-Investigator(Kenkyū-buntansha) 松本 理器  京都大学, 医学研究科, 准教授 (00378754)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords補足運動野 / 言語機能 / supplementary motor area / language function / narrative reading task / laterality / frontal aslant tract / 脳神経疾患 / 運動機能 / 前頭葉
Outline of Final Research Achievements

Connectivity within dominant frontal lobe was reliably evaluated by cortico-cortical evoked potential recording.
Due to small sample size, we could not obtain enough reproducible result in the relationship between connectivity gradient and functional localization. We are continuing patient inclusion and intraoperative recording.
As for the relationship between connectivity within dominant frontal lobe and language function, we tested functional MRI using language task and revealed that the lateralization of activation in the supplementary motor area is strongly related to the language lateralization revealed by intraarterial propofol testing.

Academic Significance and Societal Importance of the Research Achievements

言語表出に関わると推定される前頭葉内の接続性を電気生理学的に評価する方法を確立したことは、今後の脳内ネットワーク解明の一助となると考えられるとともに、臨床の面からは信頼性の高い言語機能の一面の評価方法として、術中判断の材料となる可能性を有する。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (31 results)

All 2020 2019 2018 2017

All Journal Article (20 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 20 results,  Open Access: 11 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Invited: 5 results)

  • [Journal Article] Connectivity Gradient in the Human Left Inferior Frontal Gyrus: Intraoperative Cortico-Cortical Evoked Potential Study2020

    • Author(s)
      Takuro Nakae, Riki Matsumoto, Takeharu Kunieda, Yoshiki Arakawa, Katsuya Kobayashi, Akihiro Shimotake, Yukihiro Yamao, Takayuki Kikuchi, Toshihiko Aso, Masao Matsuhashi, Kazumichi Yoshida, Akio Ikeda, Ryosuke Takahashi, Matthew A Lambon Ralph, Susumu Miyamoto
    • Journal Title

      Cerebral Cortex

      Volume: - Issue: 8 Pages: 4633-4650

    • DOI

      10.1093/cercor/bhaa065

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intraoperative electrophysiological mapping of medial frontal motor areas and functional outcomes2020

    • Author(s)
      Sumiya Shibata, Yukihiro Yamao, Takeharu Kunieda, Rika Inano, Takuro Nakae, Sei Nishida, Taku Inada, Yuki Takahashi, Takayuki Kikuchi, Yoshiki Arakawa, Kazumichi Yoshida, Riki Matsumoto, Akio Ikeda, Tatsuya Mima, Susumu Miyamoto
    • Journal Title

      World Neurosurgery

      Volume: 4 Pages: 389-404

    • DOI

      10.1016/j.wneu.2020.02.129

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human entorhinal cortex electrical stimulation evoked short-latency potentials in the broad neocortical regions: Evidence from cortico-cortical evoked potential recordings2019

    • Author(s)
      Hirofumi Takeyama, Riki Matsumoto, Kiyohide Usami, Takuro Nakae, Katsuya Kobayashi, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
    • Journal Title

      Brain and Behavior

      Volume: 9 Issue: 9

    • DOI

      10.1002/brb3.1366

    • NAID

      120006733133

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A follow-up study of the effect of training using the Hybrid Assistive Limb on Gait ability in chronic stroke patients2019

    • Author(s)
      Tanaka Hiroki、Nankaku Manabu、Nishikawa Toru、Yonezawa Honami、Mori Hiroki、Kikuchi Takayuki、Nishi Hidehisa、Takagi Yasushi、Miyamoto Susumu、Ikeguchi Ryosuke、Matsuda Shuichi
    • Journal Title

      Topics in Stroke Rehabilitation

      Volume: 26 Issue: 7 Pages: 491-496

    • DOI

      10.1080/10749357.2019.1640001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The neural tides of sleep and consciousness revealed by single-pulse electrical brain stimulation.2019

    • Author(s)
      Usami K, Korzeniewska A, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Kunieda T, Mikuni N, Kikuchi T, Yoshida K, Miyamoto S, Takahashi R, Ikeda A, Crone NE.
    • Journal Title

      Sleep.

      Volume: in press Issue: 6 Pages: 1-9

    • DOI

      10.1093/sleep/zsz050

    • NAID

      120006647295

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Spatiotemporal gait characteristic changes with gait training using the hybrid assistive limb for chronic stroke patients2019

    • Author(s)
      Tanaka Hiroki、Nankaku Manabu、Nishikawa Toru、Hosoe Takuya、Yonezawa Honami、Mori Hiroki、Kikuchi Takayuki、Nishi Hidehisa、Takagi Yasushi、Miyamoto Susumu、Ikeguchi Ryosuke、Matsuda Shuichi
    • Journal Title

      Gait & Posture

      Volume: 71 Pages: 205-210

    • DOI

      10.1016/j.gaitpost.2019.05.003

    • NAID

      120006634669

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A rational, multispectral mapping algorithm for primary motor cortex: A primary step before cortical stimulation2019

    • Author(s)
      Shuichiro Neshige, Katsuya Kobayashi, Masao Matsuhashi, Takefumi Hitomi, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Riki Matsumoto, Susumu Miyamoto, Ryosuke Takahashi, Hirofumi Maruyama, Akio Ikeda
    • Journal Title

      Epilepsia

      Volume: 60 Issue: 3 Pages: 547-559

    • DOI

      10.1111/epi.14669

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 症例 アンカーボルトを用いた定位的深部電極挿入術(stereotactic EEG insertion)の初期経験-課題の抽出と挿入精度向上の検討2018

    • Author(s)
      稲田 拓、下竹 昭寛、山尾 幸広、吉田 和道、國枝 武治、松本 理器、池田 昭夫、宮本 享、菊池 隆幸、小林 勝哉、中江 卓郎、西田 誠、高橋 由紀、小林 環、永井 靖識、松本 直樹
    • Journal Title

      Neurological Surgery 脳神経外科

      Volume: 46 Issue: 10 Pages: 917-924

    • DOI

      10.11477/mf.1436203839

    • ISSN
      0301-2603, 1882-1251
    • Year and Date
      2018-10-10
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interictal Slow and High-Frequency Oscillations: Is it an Epileptic Slow or Red Slow?2018

    • Author(s)
      Inoue T, Inouchi M, Matsuhashi M, Matsumoto R, Hitomi T, Daifu-Kobayashi M, Kobayashi K, Nakatani M, Kanazawa K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
    • Journal Title

      J Clin Neurophysiol.

      Volume: 36 Issue: 2 Pages: 166-170

    • DOI

      10.1097/wnp.0000000000000527

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resting-state functional magnetic resonance imaging identifies cerebrovascular reactivity impairment in patients with arterial occlusive diseases: A pilot study2018

    • Author(s)
      Nishida S, Aso T, Takaya S, Takahashi Y, Kikuchi T, Funaki T, Yoshida K, Okada T, Kunieda T, Togashi K, Fukuyama H, Miyamoto S
    • Journal Title

      Neurosurgery

      Volume: Epub ahead of print Issue: 5 Pages: 1-9

    • DOI

      10.1093/neuros/nyy434

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term outcomes of coil embolization of unruptured intracranial aneurysms2018

    • Author(s)
      Koyanagi Masaomi、Ishii Akira、Imamura Hirotoshi、Satow Tetsu、Yoshida Kazumichi、Hasegawa Hitoshi、Kikuchi Takayuki、Takenobu Yohei、Ando Mitsushige、Takahashi Jun C.、Nakahara Ichiro、Sakai Nobuyuki、Miyamoto Susumu
    • Journal Title

      Journal of Neurosurgery

      Volume: - Issue: 6 Pages: 1-7

    • DOI

      10.3171/2017.6.jns17174

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alteration of Venous Drainage Route in Idiopathic Normal Pressure Hydrocephalus and Normal Aging2017

    • Author(s)
      Satow Takeshi、Aso Toshihiko、Nishida Sei、Komuro Taro、Ueno Tsukasa、Oishi Naoya、Nakagami Yukako、Odagiri Masashi、Kikuchi Takayuki、Yoshida Kazumichi、Ueda Keita、Kunieda Takeharu、Murai Toshiya、Miyamoto Susumu、Fukuyama Hidenao
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 9 Pages: 387-387

    • DOI

      10.3389/fnagi.2017.00387

    • NAID

      120006533289

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Occlusion Status on Magnetic Resonance Angiography Is Associated with Risk of Delayed Ischemic Events in Cerebral Aneurysms Treated with Stent-Assisted Coiling2017

    • Author(s)
      Kikuchi Takayuki、Ishii Akira、Chihara Hideo、Arai Daisuke、Ando Mitsushige、Takenobu Yohei、Okada Tomohisa、Takagi Yasushi、Miyamoto Susumu
    • Journal Title

      World Neurosurgery

      Volume: 107 Pages: 226-232

    • DOI

      10.1016/j.wneu.2017.07.161

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Frontal Fibers Connecting the Superior Frontal Gyrus to Broca Area: A Corticocortical Evoked Potential Study2017

    • Author(s)
      Ookawa Satoshi、Enatsu Rei、Kanno Aya、Ochi Satoko、Akiyama Yukinori、Kobayashi Tamaki、Yamao Yukihiro、Kikuchi Takayuki、Matsumoto Riki、Kunieda Takeharu、Mikuni Nobuhiro
    • Journal Title

      World Neurosurgery

      Volume: 107 Pages: 239-248

    • DOI

      10.1016/j.wneu.2017.07.166

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical evaluation of time-of-flight MR angiography with sparse undersampling and iterative reconstruction for cerebral aneurysms2017

    • Author(s)
      Fushimi Yasutaka、Okada Tomohisa、Kikuchi Takayuki、Yamamoto Akira、Okada Tsutomu、Yamamoto Takayuki、Schmidt Michaela、Yoshida Kazumichi、Miyamoto Susumu、Togashi Kaori
    • Journal Title

      NMR in Biomedicine

      Volume: 30 Issue: 11

    • DOI

      10.1002/nbm.3774

    • NAID

      120006543443

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] High frequency activity overriding cortico-cortical evoked potentials reflects altered excitability in the human epileptic focus2017

    • Author(s)
      Kobayashi Katsuya、Matsumoto Riki、Matsuhashi Masao、Usami Kiyohide、Shimotake Akihiro、Kunieda Takeharu、Kikuchi Takayuki、Yoshida Kazumichi、Mikuni Nobuhiro、Miyamoto Susumu、Fukuyama Hidenao、Takahashi Ryosuke、Ikeda Akio
    • Journal Title

      Clinical Neurophysiology

      Volume: 128 Issue: 9 Pages: 1673-1681

    • DOI

      10.1016/j.clinph.2017.06.249

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] We could predict good responders to vagus nerve stimulation: A surrogate marker by slow cortical potential shift2017

    • Author(s)
      Bayasgalan Borgil、Matsuhashi Masao、Fumuro Tomoyuki、Nohira Haruhiko、Nakano Naoki、Iida Koji、Katagiri Masaya、Shimotake Akihiro、Matsumoto Riki、Kikuchi Takayuki、Kunieda Takeharu、Kato Amami、Takahashi Ryosuke、Ikeda Akio
    • Journal Title

      Clinical Neurophysiology

      Volume: 128 Issue: 9 Pages: 1583-1589

    • DOI

      10.1016/j.clinph.2017.05.019

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phasic REM transiently approaches wakefulness in the human cortex - a single-pulse electrical stimulation study.2017

    • Author(s)
      Usami K, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A.
    • Journal Title

      Sleep

      Volume: 40 Issue: 8 Pages: 1-7

    • DOI

      10.1093/sleep/zsx077

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Magnetoencephalography with temporal spread imaging to visualize propagation of epileptic activity2017

    • Author(s)
      Shibata S, Matsuhashi M, Kunieda T, Yamao Y, Rika Inano R, Kikuchi T, Imamura H, Takaya S, Matsumoto R, Ikeda A, Takahashi R, Mima T, Fukuyama H, Mikuni N, Miyamoto S
    • Journal Title

      Clin Neurophysiol

      Volume: 128 Issue: 5 Pages: 734-743

    • DOI

      10.1016/j.clinph.2017.01.010

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clinical impact of intraoperative CCEP monitoring in evaluating the dorsal language white matter pathway2017

    • Author(s)
      Yamao Y, Suzuki K, Kunieda T, Matsumoto R, Arakawa Y, Nakae T, Nishida S, Inano R, Shibata S, Shimotake A, Kikuchi, T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S
    • Journal Title

      Human Brain Mapping

      Volume: 38 (4) Issue: 4 Pages: 1977-1991

    • DOI

      10.1002/hbm.23498

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 定位頭蓋内電極留置精度の評価と向上に向けた取り組み2020

    • Author(s)
      菊池隆幸, 山尾幸広, 永井靖識, 松本直樹, 下竹昭寛, 小林勝哉, 吉田和道, 國枝武治, 松本理器, 池田昭夫, 宮本享
    • Organizer
      日本てんかん外科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 覚醒下手術におけるてんかん原性領域検索の可能性2019

    • Author(s)
      菊池隆幸, 山尾幸広, 稲田拓, 永井靖識, 松本直樹, 川崎敏生, 下竹昭寛, 溝田敏幸, 荒川芳輝, 吉田和道, 池田昭夫, 宮本享
    • Organizer
      日本Awake Surgery学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] フレーム式定位脳手術装置とアンカーボルトを用いた定位頭蓋内電極留置法の導入経験2019

    • Author(s)
      菊池隆幸, 山尾幸広, 永井靖識, 松本直樹, 下竹昭寛, 小林勝哉, 吉田和道, 國枝武治, 松本理器, 池田昭夫, 宮本享
    • Organizer
      日本てんかん学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] MRIを用いた術前後の運動機能と脳機能ネットワークの関連2019

    • Author(s)
      山尾幸広, 澤本伸克, 菊池隆幸, 荒川芳輝, 吉田和道, 國枝武治, 宮本享
    • Organizer
      日本脳神経外科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 補足運動野の活動はWada testによって判定された言語優位半球を予測する2019

    • Author(s)
      松本直樹, 麻生俊彦, 菊池隆幸, 山尾幸広, 小林環, 高橋由紀, 西田誠, 荒川芳輝, 吉田和道, 宮本享
    • Organizer
      日本脳神経外科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 言語白質モニタリングにおける皮質-皮質間誘発電位(CCEP)の有効性 ―覚醒不良例に有効か?―2019

    • Author(s)
      山尾幸広、松本理器、荒川芳輝、溝田敏幸、峰晴陽平、菊池隆幸、吉田和道、宮本享
    • Organizer
      日本Awake Surgery学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 電気生理の目2019

    • Author(s)
      山尾幸広、松本理器、菊池隆幸、吉田和道、宮本享
    • Organizer
      日本脳神経外科コングレス
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 黙読課題を用いたSMA賦活のlateralityと言語優位半球の検討: function MRI study2018

    • Author(s)
      松本 直樹 麻生俊彦 永井 靖識 小林 環 山尾 幸広 菊池 隆幸 吉田 和道 宮本 享
    • Organizer
      日本脳神経外科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 定位頭蓋内電極の導入で変化するてんかん外科における 覚醒下手術の役割2018

    • Author(s)
      菊池隆幸 稲田拓 高橋由紀 小林環 永井靖識 松本直樹 山尾幸広 吉田和道 小林勝哉 下竹昭寛 松本理器 池田昭夫 國枝武治 宮本享
    • Organizer
      日本てんかん外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 覚醒下手術における電気生理学的線維追跡法の応用ー高次脳機能温存の試みー2017

    • Author(s)
      菊池隆幸、山尾幸広、吉田和道、荒川芳輝、松本理器、國枝武治、宮本享
    • Organizer
      日本Awake surgery学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Introduction of SEEG to a single institute in Japan -A case of Kyoto University Hospital-2017

    • Author(s)
      Takayuki Kikuchi, Taku Inada, Katsuya Kobayashi, Takeharu Kunieda, Riki Matsumoto, Akio Ikeda, Susumu Miyamoto
    • Organizer
      日本てんかん学会
    • Related Report
      2017 Research-status Report
    • Invited

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Published: 2017-04-28   Modified: 2021-02-19  

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