| Project/Area Number |
17K10897
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kobe University |
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Principal Investigator |
Fujita Atsushi 神戸大学, 医学部附属病院, 講師 (60379360)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 磁気共鳴画像 / 低侵襲治療 / カテーテル治療 / カテーテル / 磁気共鳴画像支援 / 血管内治療 / 被爆 / 放射線被爆 / 放射線治療 |
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| Outline of Final Research Achievements |
In order to realize the minimally invasive neurointervention without radiation exposure, we conducted a basic study of a passive catheterization by magnetic resonance imaging (MRI). We studied optimal imaging protocols of MRI for visualized and guide a special catheter equipped with a microcoil at tip to the target blood vessel without using fluoroscopy and evaluated the heat generation of the coil. The heat generation of the catheter could be minimized by using the gradient echo sequence with acceptable contrast-noise ratio. Our study showed that specially designed catheters could be visualized and tracked in real time and treatment with catheters could be safely performed.
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| Academic Significance and Societal Importance of the Research Achievements |
我々の研究により血管内治療を行うには不可避であった被爆を減らすことが出来る可能性を示すことができ，今後の低侵襲治療の広がりに貢献できる可能性を示した．これまで大血管に限ってなされて来た研究分野をより細い血管である中枢神経系の治療にまで広げたという意義は大きい．また，磁気共鳴画像による高速撮影の研究開発は，血管内治療時におけるX線透視画像の代用となるだけでなく，通常の診断撮影においても検査時間の短縮という点で医療に貢献できると考える．
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