Analysis of neurofunctional network in resting state by intraoperative 3T fMRI

• Project/Area Number: 17K10898
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Kobe University
• Principal Investigator: Kohmura Eiji 神戸大学, 医学研究科, 教授 (30225388)
• Co-Investigator(Kenkyū-buntansha): 篠山 隆司 神戸大学, 医学部附属病院, 講師 (10379399) ; 谷口 理章 神戸大学, 医学研究科, 准教授 (60346195) ; 田中 一寛 神戸大学, 医学研究科, 助教 (70467661) ; 水川 克 神戸大学, 医学部附属病院, 非常勤講師 (80403260) ; 甲田 将章 神戸大学, 医学研究科, 助教 (80590843)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 安静時functional MRI / 頚動脈狭窄症 / 認知機能 / resting mode network / 術中MRI / 安静時脳機能ネットワーク / intraoperative MRI / functional MRI / resting state

Outline of Final Research Achievements

Internal carotid artery stenosis (ICS) can lead to cognitive impairment as well as ischemic stroke. The effect of revascularization surgery (CEA/CAS) on cognitive function is controversial. In this study, cognitive function is evaluated in ICS patients undergoing revascularization surgery with resting state-functional MRI (rs-fMRI). Significant improvement in the score of the Japanese version of the Montreal Cognitive Assessment (MOCA) was found 1 week and 3 months after revascularization surgery. Especially, the MOCA score 3 months after surgery was significantly correlated with the network of precuneus and the network between right anterior superior temporal gyrus (STG) and left posterior supramarginal gyrus (SMG). Revascularization surgery for ICS improves cognitive function. Increase of connectivity of precuneus and between right anterior STG and left posterior SMG may contribute to the cognitive improvement after revascularization surgery.

Academic Significance and Societal Importance of the Research Achievements

ICSは血管性認知症の危険因子と考えられている．申請者らは，rs-fMRIを用いた神経ネットワークによる解析法を用いて，ICSに対する手術治療(CEA/CAS)後の認知機能の変化を客観的に評価した．本研究では，ICSに対する手術治療後に認知機能が改善することが示され，その結果として，ICSに対する手術適応が拡大する可能性がある．

Research Products

• [Journal Article] Intraoperative 3-T Magnetic Resonance Spectroscopy for Detection of Proliferative Remnants of Glioma. (2020)
  • Author(s): Fujita Y, Kohta M, Sasayama T, Tanaka K, Hashiguchi M, Nagashima H, Kyotani K, Nakai T, Ito T, Kohmura E.
  • Journal Title: World Neurosurg Volume: 137 Pages: 149-157
  • DOI: 10.1016/j.wneu.2020.01.217
  • NAID: 120006993645
  • Peer Reviewed / Open Access
• [Journal Article] Machine Learning to Predict In-Hospital Morbidity and Mortality after Traumatic Brain Injury (2020)
  • Author(s): Matsuo Kazuya、Aihara Hideo、Nakai Tomoaki、Morishita Akitsugu、Tohma Yoshiki、Kohmura Eiji
  • Journal Title: Journal of Neurotrauma Volume: 37 Issue: 1 Pages: 202-210
  • DOI: 10.1089/neu.2018.6276
  • Peer Reviewed
• [Journal Article] Tumor-associated macrophage related interleukin-6 in cerebrospinal fluid as a prognostic marker for glioblastoma. (2019)
  • Author(s): Hori T, Sasayama T, Tanaka K, Koma YI, Nishihara M, Tanaka H, Nakamizo S, Nagashima H, Maeyama M, Fujita Y, Yokozaki H, Hirose T, Kohmura E.
  • Journal Title: J Clin Neurosci Volume: 68 Pages: 281-289
  • DOI: 10.1016/j.jocn.2019.07.020
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA regulating stanniocalcin-1 is a metastasis and dissemination promoting factor in glioblastoma (2019)
  • Author(s): Sakata Junichi、Sasayama Takashi、Tanaka Kazuhiro、Nagashima Hiroaki、Nakada Mitsutoshi、Tanaka Hirotomo、Hashimoto Naoya、Kagawa Naoki、Kinoshita Manabu、Nakamizo Satoshi、Maeyama Masahiro、Nishihara Masamitsu、Hosoda Kohkichi、Kohmura Eiji
  • Journal Title: Journal of Neuro-Oncology Volume: 142 Issue: 2 Pages: 241-251
  • DOI: 10.1007/s11060-019-03113-2
  • Peer Reviewed / Open Access
• [Journal Article] DWI for Monitoring the Acute Response of Malignant Gliomas to Photodynamic Therapy. (2019)
  • Author(s): Fujita Y, Sasayama T, Tanaka K, Kyotani K, Nagashima H, Kohta M, Kimura H, Fujita A, Kohmura E.
  • Journal Title: AJNR Am J Neuroradiol Volume: 40 Pages: 2045-2051
  • DOI: 10.3174/ajnr.a6300
  • Peer Reviewed / Open Access
• [Journal Article] Pencil Beam Presaturation Magnetic Resonance Imaging Helps to Identify Patients at Risk for Intolerance to Temporary Internal Carotid Artery Occlusion During Carotid Endarterectomy and Carotid Artery Stenting (2019)
  • Author(s): Tanaka Jun、Hosoda Kohkichi、Matsuo Kazuya、Kyotani Katsusuke、Takemoto Youta、Yamamoto Yusuke、Fujita Atsushi、Kohta Masaaki、Kimura Hidehito、Sasayama Takashi、Kohmura Eiji
  • Journal Title: World Neurosurgery Volume: 130 Pages: e899-e907
  • DOI: 10.1016/j.wneu.2019.07.033
  • NAID: 120006993678
  • Peer Reviewed
• [Journal Article] Clear Detection of Thin-Walled Regions in Unruptured Cerebral Aneurysms by Using Computational Fluid Dynamics (2019)
  • Author(s): Kimura H, Taniguchi M, Hayashi K, Fujimoto Y, Fujita Y, Sasayama T, Tomiyama A, Kohmura E
  • Journal Title: World Neurosurgery Volume: 121 Pages: e287-e295
  • DOI: 10.1016/j.wneu.2018.09.098
  • NAID: 120006840184
  • Peer Reviewed
• [Journal Article] Stent Expansion and In-Stent Thrombus Sign in the Trevo Stent Retriever Predict Recanalization and Possible Etiology During Mechanical Thrombectomy: A Case Series of 50 Patients with Acute Middle Cerebral Artery Occlusion (2019)
  • Author(s): Imahori Taichiro、Okamura Yusuke、Sakata Junichi、Shose Hiroyasu、Yokote Akiyoshi、Matsushima Kazushi、Matsui Daisaku、Kobayashi Makoto、Hosoda Kohkichi、Tanaka Kazuhiro、Fujita Atsushi、Kohmura Eiji
  • Journal Title: World Neurosurgery Volume: 124 Pages: e303-e311
  • DOI: 10.1016/j.wneu.2018.12.087
  • NAID: 120006826804
  • Peer Reviewed
• [Journal Article] Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion (2018)
  • Author(s): Yamamoto Yusuke、Hosoda Kohkichi、Imahori Taichiro、Tanaka Jun、Matsuo Kazuya、Nakai Tomoaki、Irino Yasuhiro、Shinohara Masakazu、Sato Naoko、Sasayama Takashi、Tanaka Kazuhiro、Nagashima Hiroaki、Kohta Masaaki、Kohmura Eiji
  • Journal Title: Brain Research Volume: 1687 Pages: 82-94
  • DOI: 10.1016/j.brainres.2018.03.001
  • Peer Reviewed
• [Journal Article] Novel Segmentation of Placed Coils in the Treatment of Cavernous Sinus Dural Arteriovenous Fistulas Provides a Reliable Predictor of the Long-Term Outcome in Abducens Nerve Palsy (2018)
  • Author(s): Kohta M, Fujita A, Tanaka J, Sasayama T, Hosoda K, Kohmura E.
  • Journal Title: World Neurosurg Volume: 113
  • Peer Reviewed
• [Journal Article] Focal hyperintensity in the dorsal brain stem of patients with cerebellopontine angle tumor: A high-resolution 3T MRI study. (2018)
  • Author(s): Yamamoto H, Fujita A, Imahori T, Sasayama T, Hosoda K, Nibu KI, Kohmura E.
  • Journal Title: Sci Rep Volume: 8 Issue: 1 Pages: 881-881
  • DOI: 10.1038/s41598-018-19232-1
  • NAID: 120006394630
  • Peer Reviewed
• [Journal Article] Novel Segmentation of Placed Coils in the Treatment of Cavernous Sinus Dural Arteriovenous Fistulas Provides a Reliable Predictor of the Long-Term Outcome in Abducens Nerve Palsy. (2018)
  • Author(s): Kohta M, Fujita A, Tanaka J, Sasayama T, Hosoda K, Kohmura E.
  • Journal Title: World Neurosurg Volume: S1878 Pages: 30179-7
  • DOI: 10.1016/j.wneu.2018.01.136
  • Peer Reviewed
• [Journal Article] Myo-inositol concentration in MR spectroscopy for differentiating high grade glioma from primary central nervous system lymphoma. (2018)
  • Author(s): Nagashima H, Sasayama T, Tanaka K, Kyotani K, Sato N, Maeyama M, Kohta M, Sakata J, Yamamoto Y, Hosoda K, Itoh T, Sasaki R, Kohmura E.
  • Journal Title: J Neurooncol. Volume: 136 Issue: 2 Pages: 317-326
  • DOI: 10.1007/s11060-017-2655-x
  • NAID: 120006769211
  • Peer Reviewed
• [Journal Article] Endoscopic endonasal surgery for pituitary adenomas extending to the oculomotor cistern. (2018)
  • Author(s): Taniguchi M, Nakai T, Kimura H, Fujita Y, Uozumi Y, Kohta M, Kohmura E.
  • Journal Title: Head Neck Volume: 40 Issue: 3 Pages: 536-543
  • DOI: 10.1002/hed.24999
  • Peer Reviewed
• [Journal Article] Endoscopic third ventriculostomy for hydrocephalus in osteopetrosis: a case report and review of the literature. (2018)
  • Author(s): Akutsu N, Koyama J, Kawamura A, Nagashima T, Taniguchi M, Kohmura E.
  • Journal Title: Childs Nerv Syst Volume: 34 Issue: 5 Pages: 991-994
  • DOI: 10.1007/s00381-018-3719-8
  • Peer Reviewed
• [Journal Article] Magnetic Resonance Spectroscopy Findings in Patients with Dural Arteriovenous Fistulas: Three Case Reports. (2017)
  • Author(s): Nagashima H, Fujita A, Tanaka J, Kohta M, Sasayama T, Tanaka K, Hosoda K, Kohmura E.
  • Journal Title: World Neurosurg Volume: 104 Pages: 1050.e7-1050.e11
  • DOI: 10.1016/j.wneu.2017.05.113
  • Peer Reviewed
• [Journal Article] Perioperative Changes in Cerebral Perfusion Territories Assessed by Arterial Spin Labeling Magnetic Resonance Imaging Are Associated with Postoperative Increases in Cerebral Blood Flow in Patients with Carotid Stenosis. (2017)
  • Author(s): Yamamoto D, Hosoda K, Uchihashi Y, Fujita A, Sasayama T, Fujii M, Sugimura K, Kohta M, Kohmura E.
  • Journal Title: World Neurosurg Volume: 102 Pages: 477-486
  • DOI: 10.1016/j.wneu.2017.03.037
  • Peer Reviewed
• [Journal Article] Cisterna magna meningiomas without dural attachment: Report of two cases. (2017)
  • Author(s): Kohta M, Sasayama T, Nakai T, Taniguchi M, Nagashima H, Tanaka K, Mizukawa K, Itoh T, Kohmura E.
  • Journal Title: Neurol Neurochir Pol Volume: 51 Issue: 3 Pages: 1-16
  • DOI: 10.1016/j.pjnns.2017.02.003
  • Peer Reviewed
• [Journal Article] Successful cerebral thrombectomy for a nonagenarian with stroke in the subacute phase after transcatheter aortic valve implantation. (2017)
  • Author(s): Matsuo K, Fujita A, Tanaka J, Nakai T, Kohta M, Hosoda K, Shinke T, Hirata KI, Kohmura E
  • Journal Title: Surg Neurol Int. Volume: 8 Issue: 1 Pages: 193-193
  • DOI: 10.4103/sni.sni_208_17
  • Peer Reviewed
• [Journal Article] Early endovascular stenting for extracranial carotid artery dissection with angiographic flow stasis: A series of four cases. (2017)
  • Author(s): Kohta M, Fujita A, Saitoh M, Hosoda K, Kohmura E.
  • Journal Title: Neurol Neurochir Pol Volume: 51 Issue: 6 Pages: 525-530
  • DOI: 10.1016/j.pjnns.2017.08.008
  • Peer Reviewed
• [Journal Article] Cognard Type V Dural Arteriovenous Fistula Involving the Occipital Sinus. (2017)
  • Author(s): Cognard Type V Dural Arteriovenous Fistula Involving the Occipital Sinus. Tanaka J, Fujita A, Maeyama M, Kohta M, Hosoda K, Kohmura E.
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 26 Issue: 4 Pages: e62-e63
  • DOI: 10.1016/j.jstrokecerebrovasdis.2017.01.004
  • Peer Reviewed
• [Presentation] Improvement of cognitive function and reorganization of brain networks following carotid endarterectomy and carotid artery stenting (2020)
  • Author(s): Masaaki Kohta, Atsushi Fujita, Kohkichi Hosoda, Eiji Kohmura
  • Organizer: ISC 2020
  • Int'l Joint Research
• [Presentation] Evaluation of Cognitive Function Using Neural Network Analysis Before and After Revascularization Surgery for Internal Carotid Artery Stenosis (2019)
  • Author(s): Masaaki Kohta, Atsushi Fujita, Kohkichi Hosoda, Eiji Kohmura
  • Organizer: BRAIN & BRAIN PET 2019
  • Int'l Joint Research
• [Presentation] 神経ネットワークを用いた頚動脈狭窄症手術前後における認知機能の評価 (2019)
  • Author(s): 甲田将章、藤田敦史、山口陽二、細田弘吉、甲村英二
  • Organizer: 第78回 日本脳神経外科学会学術総会
• [Presentation] Evaluation of Cognitive Function Using Neural Network Analysis Before and After Revascularization Surgery for Internal Carotid Artery Stenosis (2019)
  • Author(s): Masaaki Kohta, Atsushi Fujita, Kohkichi Hosoda, Eiji Kohmura
  • Organizer: Neuroscience 2019
  • Int'l Joint Research
• [Presentation] The Evaluation of Cognitive Function Using Neural Network Analysis Before and After Revascularization Surgery for Internal Carotid Artery Stenosis (2019)
  • Author(s): Masaaki Kohta, Atsushi Fujita, Kohkichi Hosoda, Eiji Kohmura
  • Organizer: ISC2019
  • Int'l Joint Research
• [Presentation] 神経ネットワークを用いた頚動脈狭窄症手術前後における認知機能の評価 (2019)
  • Author(s): 甲田将章、藤田敦史、細田弘吉、甲村英二
  • Organizer: 第44回 日本脳卒中学会学術集会
• [Presentation] 経鼻内視鏡手術における術中CISS画像の有用性について (2018)
  • Author(s): 甲田将章、谷口理章、中井友昭、甲村英二
  • Organizer: 第18回 術中画像情報学会
• [Presentation] 超高磁場術中MRIの有用性 (2018)
  • Author(s): 甲田将章
  • Organizer: 第46回 日本磁気共鳴医学会大会
• [Presentation] 神経ネットワークを用いた頚動脈狭窄症手術前後における認知機能の評価 (2018)
  • Author(s): 甲田将章、藤田敦史、細田弘吉、甲村英二
  • Organizer: 第77回 日本脳神経外科学会学術総会
• [Presentation] The usefulness of intraoperative constructive interference in steady-state MRI sequencing during endoscopic transsphenoidal surgery for pituitary adenomas (2018)
  • Author(s): Masaaki Kohta, Masaaki Taniguchi, Tomoaki Nakai, Eiji Kohmura
  • Organizer: EANS2018
  • Int'l Joint Research
• [Presentation] 神経ネットワークを用いた頚動脈ステント留置術前後における認知機能の評価 (2018)
  • Author(s): 甲田将章、藤田敦史、細田弘吉、甲村英二
  • Organizer: 第34回 日本脳神経血管内治療学会学術総会
• [Presentation] グリオーマ手術における術中MRSの現状と未来 (2017)
  • Author(s): 篠山隆司、甲田将章、田中一寛、前山昌博、中井友昭、甲村英二
  • Organizer: 第22回日本脳腫瘍の外科学会
• [Presentation] グリオーマ手術における術中MRSの現状と近未来 (2017)
  • Author(s): 甲田 将章、篠山 隆司、前山 昌博、水川 克、甲村 英二
  • Organizer: 第17回日本術中画像情報学会
• [Presentation] 3T-術中MRI支援下経鼻内視鏡下手術の有用性と問題点について (2017)
  • Author(s): 谷口 理章、中井 友昭、甲田 将章、木村 英仁、魚住 洋一、藤田 祐一、甲村 英二
  • Organizer: 第29回日本頭蓋底外科学会
• [Presentation] グリオーマ手術における術中MRSによる残存病変同定に関する検討 (2017)
  • Author(s): 甲田 将章、篠山 隆司、前山 昌博、甲村 英二
  • Organizer: 日本脳神経外科学会 第76回学術総会
• [Presentation] Intraoperative magnetic resonance spectroscopy (iMRS) for glioma surgery (2017)
  • Author(s): Takashi Sasayama, Masaaki Kohta, Kazuhiro Tanaka, Masahiro Maeyama, Hiroaki Nagashima, Tomoaki Nakai, Eiji Kohmura
  • Organizer: The 22nd Annual Meeting of Society for NeuroOncology (SNO)