| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
After establishing l-dopa induced dyskinesia Parkinson's disease rat model, I tried to modulate the function of the striosome compartment in the striatum by destroying the infralimbic cortex. But it had no therapeutic effects on dyskinesia. Then, I underwent tracing studies using AAV-DJ virus in order to find the cortex area which innervates striosome compartment in the dorsolateral striatum. I am also checking if there is an abnormality in the striosome compartment of other movement disorder mice models, i.e. q175 mice model of Huntington's disease and dystonia model mice generated by ouabain in the cerebellum. These studies are still on-going.
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