| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we investigated the potential of transplantation of neural stem cells at the chronic stage of spinal cord injury by comparing to sub-acute transplantation. Transplanted neural stem cells survived well in chronic lesion sites and generated many neurons. These neurons extended axons in host spinal cords in high numbers for long distances and connected to host neurons below injury. There was no significant difference of the number of extending axons between chronically and sub-acutely transplanted subjects. Further, chronically injured corticospinal tract axons regenerated into neural stem cells, though its extent was less robust than sub-acute transplantation. These findings indicate that early stage neural cells have a remarkable ability to extend axons over inhibitory environment at the chronic stage of spinal cord injury.
|
