Exploration of molecular biomarker for early prognostification of spinal cord injury

• Project/Area Number: 17K10921
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: University of Tsukuba
• Principal Investigator: Koda Masao 筑波大学, 医学医療系, 准教授 (50361449)
• Co-Investigator(Kenkyū-buntansha): 古矢 丈雄 千葉大学, 医学部附属病院, 講師 (00507337) ; 佐藤 守 千葉大学, 医学部附属病院, 特任准教授 (20401002)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 分子バイオマーカー / 脊髄損傷 / プロテオミクス / バイオマーカー / 血中濃度 / 予後判定 / プロテオミクス解析

Outline of Final Research Achievements

We explored the candidates for molecular biomarkers to determine injury severity and to predict neurological prognosis in acute phase of spinal cord injury (SCI) by proteomics approach. Excitatory amino acid transporter 1 (EAAT1) and Myelin-associated glycoprotein (MAG) were picked up as possible candidates for molecular biomarkers.

Academic Significance and Societal Importance of the Research Achievements

本研究で得られた分子バイオマーカー候補物質を、さらなる妥当性検証にてヒト脊髄損傷患者さんへの応用を目指す。現在のところ有効なバイオマーカーがない急性期脊髄損傷におけるバイオマーカーを開発できれば、エビデンスに基づいた治療体系構築に非常に有用である。

Research Products

• [Journal Article] Longitudinal diffusion tensor imaging of patients with degenerative cervical myelopathy following decompression surgery (2020)
  • Author(s): Kitamura Mitsuhiro、Maki Satoshi、Koda Masao、Furuya Takeo、Iijima Yasushi、Saito Junya、Miyamoto Takuya、Shiga Yasuhiro、Inage Kazuhide、Orita Sumihisa、Takahashi Hiroshi、Matsumoto Koji、Masuda Yoshitada、Yamazaki Masashi、Ohtori Seiji
  • Journal Title: Journal of Clinical Neuroscience Volume: 74 Pages: 194-198
  • DOI: 10.1016/j.jocn.2019.05.018
  • Peer Reviewed
• [Journal Article] A unidirectional porous beta-tricalcium phosphate material (Affinos?) for reconstruction of bony defects after excision of fibular bone for spinal surgery graft (2019)
  • Author(s): Noguchi Hiroshi、Funayama Toru、Koda Masao、Iijima Yasushi、Kumagai Hiroshi、Ishikawa Tetsuhiro、Aiba Atsuomi、Abe Tetsuya、Nagashima Katsuya、Miura Kousei、Izawa Shigeo、Maki Satoshi、Furuya Takeo、Yamazaki Masashi
  • Journal Title: Journal of Clinical Neuroscience Volume: 66 Pages: 71-76
  • DOI: 10.1016/j.jocn.2019.05.021
  • Peer Reviewed
• [Journal Article] Muscle Synergies During Repetitive Stoop Lifting With a Bioelectrically-Controlled Lumbar Support Exoskeleton (2019)
  • Author(s): Tan Chun Kwang, Kadone Hideki, Miura Kousei, Abe Tetsuya, Koda Masao, Yamazaki Masashi, Sankai Yoshiyuki, Suzuki Kenji
  • Journal Title: Frontiers in Human Neuroscience Volume: 13 Pages: 142-142
  • DOI: 10.3389/fnhum.2019.00142
  • NAID: 120007132788
  • Peer Reviewed / Open Access
• [Journal Article] Bone bonding, displacement, and absorption in cases of double-door laminoplasty with unidirectional porous hydroxyapatite spacers. (2019)
  • Author(s): Noguchi H, Koda M, Funayama T, Kumagai H, Abe T, Nagashima K, Miura K, Mataki K, Fujii K, Yamazaki M.
  • Journal Title: J Clin Neurosci Volume: - Pages: 46-52
  • DOI: 10.1016/j.jocn.2019.01.012
  • Peer Reviewed
• [Journal Article] Successful visualization of dynamic change of lumbar nerve root compression with the patient in both upright and prone positions using dynamic digital tomosynthesis-radiculography in patients with lumbar foraminal stenosis: An initial report of three cases. (2019)
  • Author(s): Mataki K, Koda M, Shibao Y, Kumagai H, Nagashima K, Miura K, Noguchi H, Funayama T, Abe T, Yamazaki M
  • Journal Title: J Clin Neurosci Volume: - Pages: 256-259
  • DOI: 10.1016/j.jocn.2018.12.016
  • Peer Reviewed
• [Journal Article] C5 pure motor spinal cord injury: A case with a rare manifestation of cervical spinal cord injury. (2019)
  • Author(s): Koda M, Hara Y, Okano E, Abe T, Funayama T, Noguchi H, Miura K, Nagashima K, Kumagai H, Mataki K, Yamazaki M.
  • Journal Title: J Clin Neurosci Volume: 59 Pages: 332-334
  • DOI: 10.1016/j.jocn.2018.10.014
  • Peer Reviewed
• [Presentation] Exploration for novel biomarkers of acute spinal cord injury. (2017)
  • Author(s): Koda M
  • Organizer: The 45th Annual Meeting of Cervical Spine Research Society
  • Int'l Joint Research