| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Surprisingly, after radiation exposure, some spinal tumors invade into the dura mater resulting in poor surgical and oncological outcomes. We hypothesized that radiation exposure may result in the disruption of the protections offered by the spinal dura mater. The purpose of this study was to investigate post-irradiation changes in the spinal dura mater in mice.
Intra-dural tumor invasion and disruptions of the dural microstructure were observed in the meninges of mice post-irradiation, indicating radiation-induced disruption of the dural barrier function. Disruption of dural barrier function should be acknowledged as one of the radiation-induced injuries.
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