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Investigation of the risk factor for spinal degenerative disease and neck complaint and low back pain.

Research Project

Project/Area Number 17K10937
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionWakayama Medical University

Principal Investigator

Teraguchi Masatoshi  和歌山県立医科大学, 医学部, 講師 (00554544)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords慢性腰痛 / 椎間板変性 / 終板変化 / 一般住民コホート研究 / 腰痛 / HIZ分類 / 腰痛関連ADL障害 / 大規模一般住民コホート / 脊椎加齢性変化 / High Intensity Zone / 腰痛関連生活障害 / 医学 / 老化 / 脊椎変性疾患
Outline of Final Research Achievements

We revealed that the Modic change of the lumbar spine was significantly and independently associated with the low back pain after adhustment for the disc degeneration and the nucleus pulposus displacement, which are the causes of the low back pain. In addition, the VAS score for low back pain was higher in subjects with Type I Modic changes than in subjects without Modic changes. Therefore, this results indicated that Type I Modic changes were associated with more severe low back pain.
It was published in an international journal as a research result that it can be a factor of inflammatory pain and that it is more involved in inflammatory pain than other types.

Academic Significance and Societal Importance of the Research Achievements

慢性腰痛は本邦での罹患疾病の上位である。慢性腰痛による社会的損失は大きいが、明らかな腰痛を引き起こす原因は不明である。本研究の成果として、椎間板周囲の終板変化(Modic変化)は腰痛の原因とされて他因子を除いても、強い腰痛との相関がみられたため腰痛の原因の一つであることが大規模一般住民コホート研究において証明されたと考える。この結果は社会的に大変意義のある研究であると考えており、引き続き継続していきたいと思います。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (17 results)

All 2022 2021 2020 2019 2018 2017

All Journal Article (11 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 11 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] A Prospective, 3-year Longitudinal Study of Modic Changes of the Lumbar Spine in a Population-based Cohort2022

    • Author(s)
      Tamai Hidenobu
    • Journal Title

      SPINE

      Volume: 47 Pages: 490-497

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detailed Subphenotyping of Lumbar Modic Changes and Their Association with Low Back Pain in a Large Population-Based Study: The Wakayama Spine Study2022

    • Author(s)
      Teraguchi Masatoshi
    • Journal Title

      Pain and Therapy

      Volume: 11 Pages: 57-71

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between types of Modic changes in the lumbar region and low back pain in a large cohort: the Wakayama spine study2021

    • Author(s)
      Mera Y, Teraguchi M, Hashizume H, et al.
    • Journal Title

      European Spine Journal

      Volume: 30 Issue: 4 Pages: 1011-1017

    • DOI

      10.1007/s00586-020-06618-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Lumbar high-intensity zones on MRI: imaging biomarkers for severe, prolonged low back pain and sciatica in a population-based cohort.2020

    • Author(s)
      Masatoshi Teraguchi
    • Journal Title

      The Spine Journal

      Volume: in Press Issue: 7 Pages: 1025-1034

    • DOI

      10.1016/j.spinee.2020.02.015

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical Features of Sarcopenia in Patients with Lumbar Spinal Stenosis.2020

    • Author(s)
      Matsuo Sachika
    • Journal Title

      Spine

      Volume: in Press Issue: 17 Pages: E1105-E1110

    • DOI

      10.1097/brs.0000000000003498

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prevalence of Facet Effusion and Its Relationship with Lumbar Spondylolisthesis and Low Back Pain: The Wakayama Spine Study.2019

    • Author(s)
      Shinto Kazuhiro
    • Journal Title

      Journal of Pain Research

      Volume: 12 Pages: 3521-3528

    • DOI

      10.2147/jpr.s227153

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Therapeutic Advantages of Frequent Physical Therapy Sessions for Patients with Lumbar Spinal Stenosis.2019

    • Author(s)
      MInetama Masafumi
    • Journal Title

      Spine

      Volume: in Press Issue: 11 Pages: E639-E646

    • DOI

      10.1097/brs.0000000000003363

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Serum levels of matrix metalloproteinase and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study.2018

    • Author(s)
      R Kodama, S Muraki, T Iidaka, H Oka, M Teraguchi, R Kagotani, Y Asai, H Hashizume, M Yoshida, H Kawaguchi, K Nakamura, T Akune, S Tanaka, N Yoshimura
    • Journal Title

      J Bone Miner Metab

      Volume: 36 Pages: 246-253

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 椎椎間板変性の新規発生の危険因子について -The Wakayama Spine Study-2018

    • Author(s)
      寺口 真年
    • Journal Title

      雑誌 和歌山医学

      Volume: 68 Pages: 148-150

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum Levels of Matrix Metalloproteinase-3 and Autoantibodies Related to 2 Rheumatoid Arthritis in the General Japanese Population and their Association with Osteoporosis and Osteoarthritis: The ROAD Study2017

    • Author(s)
      Kodama R, Muraki S, Iidaka T, Oka H, Teraguhi M, Kagotani R, Asai Y, Hashizume H, Yoshida M, Kawaguchi H, Nakamura K, Akune T, Tanaka S, Yoshimura N.
    • Journal Title

      J Bone Miner Metab

      Volume: in press Issue: 2 Pages: 246-253

    • DOI

      10.1007/s00774-017-0834-7

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Progression, incidence, and risk factors for intervertebral disc degeneration in a longitudinal population-based cohort: the Wakayama Spine Study.2017

    • Author(s)
      M Teraguchi, N Yoshimura, H hashizume, H Yamada, H Oka, A Minamide, K Nagata, Y Ishimoto, R Kagotani, H Kawaguchi, S Tanaka, T Akune, K Nakamura, S Muraki, M Yoshida
    • Journal Title

      Osteoarthritis and Cartilage

      Volume: 25 Pages: 1122-31

    • NAID

      40021443587

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Detailed Subphenotyping of Lumbar Modic Changes and Their Association with Low Back Pain in a Large Population-Based Study: The Wakayama Spine Study2021

    • Author(s)
      Teraguchi Masatoshi
    • Organizer
      ISSLS
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Prospective, 3-year Longitudinal Study of Modic Changes of the Lumbar Spine in a Population-based Cohort2021

    • Author(s)
      Tamai Hidenobu
    • Organizer
      ISSLS
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] AGEs are associated with the intensity of back pain symptoms in patients with lumbar spinal stenosis2020

    • Author(s)
      Teraguchi Masatoshi
    • Organizer
      ISSLS
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sagittal imbalance of the spine-pelvis-lower extremity axis is associated with back-related disability in inhabitant volunteers2019

    • Author(s)
      Masatoshi Teraguchi
    • Organizer
      Biospine Japan 1st meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Lumbar high-intensity zones on MRI: imaging biomarkers for severe, prolonged low back pain and sciatica in a population-based cohort2017

    • Author(s)
      M. Teraguchi, J. Cheung, J. Karppinen, C. Bow, H. Hashizume, K. Luk, K. Cheung, D Samartzis.
    • Organizer
      International society for study of lumbar spine
    • Related Report
      2017 Research-status Report
  • [Presentation] Efficacy of blood injection therapy for stopping cerebrospinal fluid leakage after lumbar spine surgery.2017

    • Author(s)
      M. Teraguchi, M. Kawakami, N. Moriguchi, Y. Ishimoto
    • Organizer
      The 17 th Annual Meeting of the Pacific and Asian Society of Minimally Invasive Spine Surgery
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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