Demonstration of transplanted Bone marrow derived mesenchymal stem/progenitor cells (MSCs) homing and co-effect of kinetic therapy on the spinal cord injury
| Project/Area Number |
17K10943
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大滝 博和 昭和大学, 医学部, 准教授 (20349062)
渡邊 潤 昭和大学, 大学共同利用機関等の部局等, 兼任講師 (50649069)
吉川 輝 昭和大学, 保健医療学部, 講師 (90737355)
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 整形外科学 / 脊髄損傷 / 細胞移植 / 骨髄間葉系幹細胞 / リハビリテーション / 動作解析 / モーションキャプチャー / マクロファージ / ケモカイン / ヒト間葉系幹細胞 / 神経再生 / マウス / 神経科学 / 再生医学 / 移植・再生医療 / 動物 |
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| Outline of Final Research Achievements |
The patients subjected to spinal cord injury (SCI) are relatively younger age. Therefore, while the patients suffer for a long-periods, they have a potential to recover their lost functions by a regeneration. Bone marrow derived mesenchymal stem/progenitor cells (MSCs) have tried the clinical studies for the SCI. Moreover, the MSCs are known to modulate macrophage/microglial cells (MP/MG) polarization. However, it is still unclear about a communication between the MSCs and MP/MG, and the contribution of the chemokines. In present study, we determined hMSCs improved clinical symptoms after SCI and increased chemokines communicated with host parenchymal cells and the CCL5 which increased 14 says after SCI and hMSCs implant may contribute to MP/MG polarization for tissue repairing and axonal extension.
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| Academic Significance and Societal Importance of the Research Achievements |
脊髄損傷は若年齢患者が多い疾患である。それ故，患者が長期の不自由な生活になる一方，再生も期待される。骨髄間葉系幹・前駆細胞（MSCs）は脊髄損傷の臨床試験が行われている。一方でどのように機能回復が起きるのかその分子機構は不明である。報告者らはマウス脊髄損傷モデルを用いヒトMSCsを移植した際にMSCsは漸次的に低下するが生体内のマクロファージ・マイクログリアが細胞の遊走に関与するケモカインのCCL5の誘導を介して神経再生を促進する可能性を示した。
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Report
(6 results)
Research Products
(142 results)
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[Journal Article] Optogenetic activation of DRN 5-HT neurons induced active wakefulness, not quiet wakefulness.2021
Author(s)
Moriya R, Kanamaru M, Okuma N, Yoshikawa A, Tanaka KF, Hokari S, Ohshima Y, Yamanaka A, Honma M, Onimaru H, Kikuchi T, Izumizaki M.
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Journal Title
Brain Res Bull.
Volume: 177
Pages: 129-142
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Entorhinal cortex and parahippocampus volume reductions impact olfactory decline in aged subjects2021
Author(s)
izuka N, Masaoka Y, Kubota S, Sugiyama H, Yoshida M, Yoshikawa A, Koiwa N, Honma M, Watanabe K, Kamijo S, Kamimura S, Ida M, Ono K, Izumizaki M.
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Journal Title
Brain and Behavior
Volume: 11
Issue: 5
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Pituitary adenylate cyclase-activating polypeptide promotes eccrine gland sweat secretion.2017
Author(s)
Sasaki S, Watanabe J, Ohtaki H, Matsumoto M, Murai N, Nakamachi T, Hannibal J, Fahrenkrug J, Hashimoto H, Watanabe H, Sueki H, Honda K, Miyazaki A, Shioda S.
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Journal Title
Br J Dermatol.
Volume: 176
Issue: 2
Pages: 413-422
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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