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Mechanism of osteoclast formation in periprosthetic osteolysis

Research Project

Project/Area Number 17K10957
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Nakamura Miho  東京医科歯科大学, 生体材料工学研究所, 非常勤講師 (40401385)

Co-Investigator(Kenkyū-buntansha) 山下 仁大  東京医科歯科大学, 歯学部, 非常勤講師 (70174670)
堀内 尚紘  東京医科歯科大学, 生体材料工学研究所, 助教 (90598195)
Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords破骨細胞 / 人工関節 / 骨溶解
Outline of Final Research Achievements

Although total joint replacement surgery is one of the most successful clinical procedures performed, osteolysis remains a major problem for many patients. The purpose of this study is to elucidate the mechanism of osteolysis around orthopedic implants and to apply it to material design for prevention and treatment of osteolysis. The electro microscopic analysis of the histological sections around the implant identified the chemical composition on the surfaces and inside of the metal wear debris. In addition, we performed a material analysis of bone minerals at the stress shielding site around the implants and examined the carbonate contents and electrical energy in the bone minerals.

Academic Significance and Societal Importance of the Research Achievements

人口の急速な高齢化に伴い、骨粗鬆症等が原因の人工関節置換例が増加している。人工関節置換術は20世紀に開発された整形外科治療で最も成功している治療法のひとつとして評価されている。しかし、近年、人工関節のゆるみが進行し、再置換が必要となる症例が増加している。本研究では、人工関節周囲でゆるみを引き起こす原因の一つである骨溶解に着目した。本研究成果に基づき、骨溶解機構を解明することで、骨溶解防止のための新しいバイオマテリアルデザインに寄与することが期待される。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (55 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (4 results) Journal Article (14 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 11 results,  Open Access: 11 results) Presentation (36 results) (of which Int'l Joint Research: 20 results,  Invited: 22 results) Book (1 results)

  • [Int'l Joint Research] トゥルク大学(フィンランド)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] University of Oulu/Faculty of Medicine/Department of Anatomy and Cell Biology(フィンランド)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] University of Turku/Faculty of Medicine/Institute of Biomedicine(フィンランド)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] University of Oulu(Finland)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Surface Electric Fields Increase Human Osteoclast Resorption through Improved Wettability on Carbonate-Incorporated Apatite2021

    • Author(s)
      Bergara-Muguruza Leire、M?kel? Keijo、Yrj?l? Tommi、Salonen Jukka、Yamashita Kimihiro、Nakamura Miho
    • Journal Title

      ACS Applied Materials & Interfaces

      Volume: 13 Issue: 49 Pages: 58270-58278

    • DOI

      10.1021/acsami.1c14358

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inhibition of osteoclast activities by SCPC bioceramic promotes osteoblast-mediated graft resorption and osteogenic differentiation.2021

    • Author(s)
      El-Ghannam A, Nakamura M, Muguruza LB, Sarwar U, Hassan M, Fotawi RAI, Horowitz R.
    • Journal Title

      J Biomed Mater Res

      Volume: - Issue: 9 Pages: 1-12

    • DOI

      10.1002/jbm.a.37167

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structural and elemental characterization of glass and ceramic particles for bone surgery2021

    • Author(s)
      Sirkia Saara V.、Nakamura Miho、Qudsia Syeda、Siekkinen Minna、Sm?tt Jan-Henrik、Peltonen Jouko、Heino Terhi J.、Hupa Leena、Vallittu Pekka K.
    • Journal Title

      Dental Materials

      Volume: 37 Issue: 9 Pages: 1350-1357

    • DOI

      10.1016/j.dental.2021.06.004

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Polymer for Application as a Matrix Phase in a Concept of In Situ Curable Bioresorbable Bioactive Load-Bearing Continuous Fiber Reinforced Composite Fracture Fixation Plates.2021

    • Author(s)
      Plyusnin A, He J, Elschner C, Nakamura M, Kulkova J, Spickenheuer A, Scheffler C, Lassila LV.J, Moritz N.
    • Journal Title

      Molecules

      Volume: 26 Issue: 5 Pages: 1256-1256

    • DOI

      10.3390/molecules26051256

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhanced new bone formation in canine maxilla by a graft of electrically polarized β-tricalcium phosphate2020

    • Author(s)
      Nohara Kohei、Itoh Soichiro、Akizuki Tatsuya、Nakamura Miho、Fukuba Shunsuke、Matsuura Takanori、Okada Munehiro、Izumi Yuichi、Iwata Takanori、Yamashita Kimihiro
    • Journal Title

      Journal of Biomedical Materials Research Part B: Applied Biomaterials

      Volume: - Issue: 7 Pages: 2820-2826

    • DOI

      10.1002/jbm.b.34612

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Osteoclasts secrete osteopontin into resorption lacunae during bone resorption2019

    • Author(s)
      Luukkonen Jani、Hilli Meeri、Nakamura Miho、Ritamo Ilja、Valmu Leena、Kauppinen Ky?sti、Tuukkanen Juha、Lehenkari Petri
    • Journal Title

      Histochemistry and Cell Biology

      Volume: 印刷中 Issue: 6 Pages: 475-487

    • DOI

      10.1007/s00418-019-01770-y

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Peripheral blood monocytes show increased osteoclast differentiation potential compared to bone marrow monocytes2018

    • Author(s)
      Kylm?oja Elina、Nakamura Miho、Turunen Sanna、Patlaka Christina、Andersson G?ran、Lehenkari Petri、Tuukkanen Juha
    • Journal Title

      Heliyon

      Volume: 4 Issue: 9 Pages: e00780-e00780

    • DOI

      10.1016/j.heliyon.2018.e00780

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gap junctional communication is involved in differentiation of osteoclasts from bone marrow and peripheral blood monocytes.2018

    • Author(s)
      Kylmaoja E, Nakamura M, Kokkonen-Puuoer H, Veli-Pekka R, Lehenkari, P, Tuukkanen J.
    • Journal Title

      Helion

      Volume: 4 Issue: 5 Pages: e00621-e00621

    • DOI

      10.1016/j.heliyon.2018.e00621

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A critical phenomenon of phase transition in hydroxyapatite investigated by thermally stimulated depolarization currents.2017

    • Author(s)
      Horiuchi N, Iwasaki Y, Nozaki K, Nakamura M, Hashimoto K, Nagai A, Yamashita K.
    • Journal Title

      J Am Ceram Soc

      Volume: 100 Issue: 2 Pages: 501-505

    • DOI

      10.1111/jace.14620

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crystallization of Calcium Phosphate in Agar Hydrogels in the Presence of Polyacrylic Acid under Double Diffusion Conditions.2017

    • Author(s)
      Wada N, Horiuchi N, Nishio M, Nakamura M, Nozaki K, Nagai A, Hashimoto K, Yamashita K.
    • Journal Title

      Cryst. Growth Des

      Volume: 17 Issue: 2 Pages: 604-611

    • DOI

      10.1021/acs.cgd.6b01453

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hydroxyapatite as a nanomaterial for tissue engineering and drug therapy.2017

    • Author(s)
      Tuukkanen J, Nakamura M.
    • Journal Title

      Curr Pharm Design

      Volume: 23 Issue: 26 Pages: 3786-3793

    • DOI

      10.2174/1381612823666170615105454

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 無機エレクトレットによるバイオミネラリゼーションの制御2017

    • Author(s)
      中村美穂, 山下仁大.
    • Journal Title

      月刊地球

      Volume: 31 Pages: 49-56

    • Related Report
      2017 Research-status Report
  • [Journal Article] バイオセラミックスの高機能化2017

    • Author(s)
      中村美穂, 山下仁大
    • Journal Title

      PHOSPHORUS LETTER

      Volume: 88 Pages: 402-409

    • Related Report
      2017 Research-status Report
  • [Journal Article] ポーリングによるバイオセラミックスの高機能化2017

    • Author(s)
      中村美穂, 山下仁大.
    • Journal Title

      FC report

      Volume: 35 Pages: 52-57

    • NAID

      40021193413

    • Related Report
      2017 Research-status Report
  • [Presentation] Improvement of surface wettability and cellular interactions by bioceramic eletcrets.2021

    • Author(s)
      Nakamura M
    • Organizer
      he 14th Pacific Rim Conference of Ceramic Societies (Pacrim13)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Designed biomaterials to mimic the mechanical properties of bone.2021

    • Author(s)
      Nakamura M
    • Organizer
      International Workshop Bioelectronic Medicine
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A new concept of hydroxyapatite for bone regeneration -nano structure and response to mechanical strain2021

    • Author(s)
      Nakamura M
    • Organizer
      The 16th International Workshop on Biomaterials in Interface Science
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Material and biological studies on ceramic biomaterials for bone regeneration.2019

    • Author(s)
      Nakamura M, Yamashita K.
    • Organizer
      The 4th International Symposium on Biomedical Engineering
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Artificial Bones for tissue regeneration.2019

    • Author(s)
      Nakamura M
    • Organizer
      International Forum on Research Promotion 2019.
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Activation of bone cells by piezoelectricity and nanocrystals in bone matrix.2019

    • Author(s)
      Nakamura M
    • Organizer
      The 13rd Pacific Rim Conference of Ceramic Societies (Pacrim13)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Finland is a pioneer in gender equality2019

    • Author(s)
      Nakamura M
    • Organizer
      The 13rd Pacific Rim Conference of Ceramic Societies (Pacrim13)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] A new concept for hydroxyapatite in bone remodeling; the nano structure and response to mechamical strain.2019

    • Author(s)
      Nakamura M
    • Organizer
      4th International Conference on Innovations in Biomaterials, Biomanufacturing, and Biotechnologies (Bio-4)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Understanding of interactions between cells and polarized bioceramics.2019

    • Author(s)
      Nakamura M
    • Organizer
      Signaling Biomaterials Research Symposium
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Activation of osteogenic cells by piezoelectricity and nanocrystals in bone matrix.2019

    • Author(s)
      Nakamura M
    • Organizer
      MRS 2019 Spring Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Artificial Bones for tissue regeneration; Multidisciplinary collaborations between Finland and Japan2019

    • Author(s)
      Nakamura M
    • Organizer
      JSPS Alumni Meeting in Finland 10-year anniversary ceremony
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Role of material characteristics in regulating bone cell differentiation.2019

    • Author(s)
      Nakamura M, Hentunen T, Salonen J, Yamashita K.
    • Organizer
      Annual Meeting of Scandinavian Society for Biomaterials 2019
    • Related Report
      2019 Research-status Report
  • [Presentation] Artificial bones for tissue regeneration- Multidisciplinary collaborations between Finland and Japan.2019

    • Author(s)
      Miho Nakamura.
    • Organizer
      All Alumni Meeting- the 100-year anniversary of diplomatic relations between Finland and Japan
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Understanding of cell-bioceramic interactions in terms of materials science.2018

    • Author(s)
      Nakamura M.
    • Organizer
      30th Symposium and Annual Meeting of the International Society for Ceramics in medicine (Bioceramics30)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Hydroxyapatite with high carbonate substitutions promotes osteoclast resorption.2018

    • Author(s)
      Nakamura M
    • Organizer
      GC Symposium on "Bone regeneration and biomaterials with an emphasis of periodontal and peri-implant bone defects"
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Banked bone intended for clinical use contains stored piezoelectrical energy.2018

    • Author(s)
      Miho Nakamura, Kimihiro Yamashita, Petri Lehenkari.
    • Organizer
      Finland-Japan Workshop: The next generation medical engineering in biomaterials.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Activation of cell function by piezoelectricity of collagen fibrils and nano crystals in bone matrix.2018

    • Author(s)
      Miho Nakamura, Petri Lehenkari, Kimihiro Yamashita.
    • Organizer
      Frontier 2018 Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Surface free energy predominates in cell adhesion to ceramic biomaterials.2018

    • Author(s)
      Miho Nakamura, Hiroshi Ando, Saki Namba, Takeshi Toyama, Nobuyuki Nishimiya, Petri Lehenkari, Juha Tuukkanen, Kimihiro Yamashita.
    • Organizer
      29th European Conference on Biomaterials
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] アパタイトミネラルに蓄積された電気的エネルギ-による細胞機能制御.2018

    • Author(s)
      中村美穂、堀内尚紘、山下仁大.
    • Organizer
      学際・国際的高度人材養成ライフイノベ-ションマテリアル創製共同研究プロジェクト(6大学連携プロジェクト)公開討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] 骨再生医療材料の表面科学と細胞制御.2018

    • Author(s)
      中村美穂.
    • Organizer
      日本再生医療学会.
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Surface electric fields of bioceramic electrets promote cell adhesion.2018

    • Author(s)
      Nakamura M, Yamashita K.
    • Organizer
      42nd International Conference and Exposition on Advanced Ceramics and Composites
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] A new concept for hydroxyapatite in bone remodeling-the nano structure and response to mechanical strain.2018

    • Author(s)
      Nakamura M.
    • Organizer
      34th Annual Meeting for southern biomedical engineering conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] アパタイトミネラルに蓄積された電気的エネルギ―による細胞機能制御2018

    • Author(s)
      中村美穂、堀内 尚紘、山下仁大.
    • Organizer
      学際・国際高度人材育成ライフイノベ―ションマテリアル創製共同研究プロジェクト公開討論会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 骨再生医療材料の表面科学と細胞制御2018

    • Author(s)
      中村美穂
    • Organizer
      日本再生医療学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 分極ゼオライトの電気特性評価2018

    • Author(s)
      中村美穂、米山祥平、吉田直哉、大倉利典、山下仁大
    • Organizer
      日本セラミックス協会 2018 年年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Hydroxyapatite with high carbonate substitutions promotes osteoclast differentiation through osteocyte-like cells.2017

    • Author(s)
      M. Nakamura, K. Yamashita.
    • Organizer
      Finnish Bone Society Meeting 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Banked bone intended for clinical use as an electrical energy resourvoir.2017

    • Author(s)
      M. Nakamura, K. Yamashita, J. Tuukkanen, P. Lehenkari.
    • Organizer
      Finnish Bone bank meeting 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Understanding of cell-biomaterial interactions in terms of surface and materials science.2017

    • Author(s)
      M. Nakamura, K. Yamashita.
    • Organizer
      International Symposium on Biomedical and Environmental Materials
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Hydroxyapatite with high carbonate substitutions promotes osteoclast formation in vitro and in vivo.2017

    • Author(s)
      M. Nakamura, R.Hiratai, T. Hentunen, J. Salonen, K. Yamashita.
    • Organizer
      European Society for Biomaterials 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] バイオマテリアル表面科学に着目した基礎研究2017

    • Author(s)
      中村美穂.
    • Organizer
      無機リン産学連携講座
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] プロトン伝導を利用したセラミックエレクトレット2017

    • Author(s)
      堀内 尚紘,野崎 浩佑,中村 美穂,永井 亜希子,山下 仁大,遠山 岳史.
    • Organizer
      平成28年度生体医歯工学共同研究拠点成果報告会
    • Related Report
      2017 Research-status Report
  • [Presentation] カルボン酸を用いた板状水酸アパタイトの合成.2017

    • Author(s)
      堀内尚紘,野崎浩佑,中村美穂,永井亜希子,山下仁大
    • Organizer
      無機マテリアル学会第 134 回学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 水酸アパタイトエレクトレットの特性に与える焼結条件の影響2017

    • Author(s)
      大塚 啓介, 堀内 尚紘, 野崎 浩佑, 中村 美穂, 永井 亜希子, 山下 仁大.
    • Organizer
      日本セラミックス協会 第 30 回秋季シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] 二価のカルボン酸を用いた板状水酸アパタイトの水熱合成2017

    • Author(s)
      堀内 尚紘, 野崎 浩佑, 中村 美穂, 永井 亜希子, 山下 仁大
    • Organizer
      日本セラミックス協会 第 30 回秋季シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] 界面分極を利用した水酸アパタイトエレクトレットの作製とその帯電特性2017

    • Author(s)
      堀内 尚紘, 大塚 啓介, 野崎 浩佑, 中村 美穂, 永井 亜希子, 山下 仁大
    • Organizer
      第 37 回エレクトロセラミックス研究討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] 熱刺激脱分極電流法を用いたハイドロキシアパタイトエレクトレットの特性評価.2017

    • Author(s)
      堀内 尚紘, 大塚 啓介, 野崎 浩佑, 中村 美穂, 永井 亜希子, 山下 仁大
    • Organizer
      第 39 回 バイオマテリアル学会大会
    • Related Report
      2017 Research-status Report
  • [Book] Handbook of Solid State Chemistry2017

    • Author(s)
      Horiuchi N, Nakamura M, Wada N, Yamashita K, Nagai A.
    • Total Pages
      3756
    • Publisher
      Wily
    • ISBN
      9783527325870
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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