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Functional collagen device for cartilage defect repair and regeneration

Research Project

Project/Area Number 17K10965
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionOsaka University

Principal Investigator

MYOUI Akira  大阪大学, 医学部附属病院, 教授 (10263261)

Co-Investigator(Kenkyū-buntansha) 岡本 美奈  大阪大学, 医学部附属病院, 助教 (50457008)
吉川 秀樹  大阪大学, 医学系研究科, 理事・副学長 (60191558)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsウロコ由来Ⅰ型コラーゲン / 軟骨再生 / 高強度コラーゲン膜/コラーゲン多孔体複合デバイス / コラーゲンスポンジ / 骨軟骨欠損 / 軟骨欠損補填 / うろこコラーゲン / 線維膜/多孔質複合材料 / 間葉系幹細胞
Outline of Final Research Achievements

Fish scale-derived type I collagen has the unique feature of being able to reproduce the same fibrous structure as biological tissue. It is extremely strong compared to conventional collagen-derived biomaterial and highly promotes cell differentiation. It also has workability to be prepared as sponge-like structure, sheet-like, etc. We examined the utility of this new biomaterial in the treatment of cartilage lesions. Our results suggest its usefullness as a highly safe and high-strength cell-free cartilage defect repair material and also as a scaffold for cartilage regeneration products.

Academic Significance and Societal Importance of the Research Achievements

軟骨欠損のセルフリー修復材料はこれまでに開発されておらず、本マテリアルは生体親和性が高く、有用な軟骨欠損補填デバイス/再生スキャフォールドとなる可能性が示唆された。この材料は魚類由来であり病原伝搬性の観点からも優れる可能性がある。軟骨疾患は高齢化社会における寝たきりの重大な原因の一つであり、その治療に貢献することは、公衆衛生の面でも、医療経済面でも高い意義が期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (2 results)

All 2019

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Transplantation of autologous bone marrow-derived mesenchymal stem cells under arthroscopic surgery with microfracture versus microfracture alone for articular cartilage lesions in the knee: A multicenter prospective randomized control clinical trial.2019

    • Author(s)
      Hashimoto Y, Nishida Y, Takahashi S, Nakamura H, Mera H, Kashiwa K, Yoshiya S, Inagaki Y, Uematsu K, Tanaka Y, Asada S, Akagi M, Fukuda K, Hosokawa Y, Myoui A, Kamei N, Ishikawa M, Adachi N, Ochi M, Wakitani S.
    • Journal Title

      Regan Ther

      Volume: 28 Pages: 106-113

    • DOI

      10.1016/j.reth.2019.06.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-Dimensional Corrective Osteotomy for Malunited Fractures of the Upper Extremity Using Patient-Matched Instruments: A Prospective, Multicenter, Open-Label, Single-Arm Trial.2019

    • Author(s)
      Oka K, Tanaka H, Okada K, Sahara W, Myoui A, Yamada T, Yamamoto M, Kurimoto S, Hirata H, Murase T.
    • Journal Title

      J Bone Joint Surg Am

      Volume: 101 Pages: 710-721

    • Related Report
      2018 Research-status Report
    • Peer Reviewed

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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