Establishment of the testing targeted for CD109 antigen in soft tissue sarcoma
Project/Area Number |
17K10974
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Sapporo Medical University |
Principal Investigator |
Emori Makoto 札幌医科大学, 医学部, 講師 (20580286)
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Co-Investigator(Kenkyū-buntansha) |
塚原 智英 札幌医科大学, 医学部, 准教授 (20404634)
清水 淳也 札幌医科大学, 医学部, 道兼任教員 (00826802)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 軟部肉腫 / CD109 / バイオマーカー / 骨・軟部腫瘍 |
Outline of Final Research Achievements |
The purpose of this study is to establish the testing to detect early local recurrence or distant metastasis in soft tissue sarcomas. CD109 is a TGF-b co-receptor that regulates TGF-b receptor endocytosis and degrading. This relation may be associated with tumor proliferation, and immunohistochemical studies have demonstrated high level of expression in various cancers. We investigated the amount of CD109 antigen in serum in four patients who developed distant metastasis and compared the amount of CD109 between the preoperative and the distant metastasis phase. However, there were no significant change.
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Academic Significance and Societal Importance of the Research Achievements |
軟部肉腫においては、癌種のように再発・転移の早期発見を可能とする腫瘍マーカーは存在しない。我々は軟部肉腫において早期の再発・転移の検出を可能とするような血清マーカーの同定を目指した。特にCD109に着目した。しかしCD109においては、再発・転移時にも血清存在中のCD109抗原量に有意な差は認められず、再発・転移の検出を可能とするマーカーとはなりえなかった。今後新しいマーカーの同定が必要である。
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Identification of Coiled-Coil Domain-Containing Protein 180 and Leucine-Rich Repeat-Containing Protein 4 as Potential Immunohistochemical Markers for Liposarcoma Based on Proteomic Analysis Using Formalin-Fixed, Paraffin-Embedded Tissue.2019
Author(s)
Aoyama T, Takasawa A, Takasawa K, Ono Y, Emori M, Murata M, Hayasaka T, Fujitani N, Osanai M, Yamashita T, Hasegawa T, Sawada N.
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Journal Title
Am J Pathol.
Volume: in press
Issue: 5
Pages: 1015-1028
DOI
Related Report
Peer Reviewed
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[Journal Article] Early Lymph Node Metastasis May Predict Poor Prognosis in Soft Tissue Sarcoma2019
Author(s)
Emori Makoto、Tsuchie Hiroyuki、Nagasawa Hiroyuki、Sonoda Tomoko、Tsukamoto Arihiko、Shimizu Junya、Murahashi Yasutaka、Mizushima Emi、Takada Kohichi、Murase Kazuyuki、Iesato Kotoe、Igarashi Keita、Hori Tsukasa、Yamamoto Masaki、Sugita Shintaro、Miyakoshi Naohisa、Hasegawa Tadashi、Shimada Yoichi、Yamashita Toshihiko
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Journal Title
International Journal of Surgical Oncology
Volume: 2019
Pages: 1-5
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan: from a questionnaire for JCOG 1610 study2018
Author(s)
Urakawa H, Yonemoto T, Matsumoto S, Takagi T, Asanuma K, Watanuki M, Takemoto A, Naka N, Matsumoto Y, Kawai A, Kunisada T, Kubo T, Emori M, Hiraga H, Hatano H, Tsukushi S, Nishida Y, Akisue T, Morii T, Takahashi M, Nagano A, Yoshikawa H, Sato K, Kawano M, Hiraoka K, Tanaka K, Iwamoto Y, Ozaki T.
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Journal Title
World Journal of Surgical Oncology
Volume: 16
Issue: 1
Pages: 162-162
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Prospective comparison of various radiological response criteria and pathological response to preoperative chemotherapy and survival in operable high-grade soft tissue sarcomas in the Japan Clinical Oncology Group study JCOG03042018
Author(s)
Tanaka K, Ogawa G, Mizusawa J, Naka N, Kawai A, Takahashi M, Hiruma T, Matsumoto Y, Tsuchiya H, Nakayama R, Hatano H, Emori M, Hosaka M, Yoshida Y, Toguchida J, Abe S, Asanuma K, Yokoyama R, Hiraga H, Yonemoto T, Morii T, Matsumoto S, Nagano A, Yoshikawa H, Fukuda H, Ozaki T, Iwamoto Y.
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Journal Title
World Journal of Surgical Oncology
Volume: 16
Issue: 1
Pages: 160-160
DOI
Related Report
Peer Reviewed
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[Journal Article] CD109は粘液線維肉腫の予後予測因子である2017
Author(s)
江森誠人, 塚原智英, 杉田真太朗, 園田智子, 村橋靖崇, 清水淳也, 水島衣美, 相馬有, 佐々木幹人, 加谷光規, 名越智, 長谷川匡, 和田卓郎, 山下敏彦
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Journal Title
北海道整災外
Volume: 59
Pages: 6-10
Related Report
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[Journal Article] Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.2017
Author(s)
Shibayama Y, Tsukahara T, Emori M, Murata K, Mizushima E, Hirohashi Y, Kanaseki T, Nakatsugawa M, Kubo T, Yamashita T, Sato N, Torigoe T
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Journal Title
Cancer Science
Volume: 108
Issue: 9
Pages: 1739-1745
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Atypical presentation of primary pulmonary epithelioid sarcoma misdiagnosed as non-small cell lung cancer.2017
Author(s)
Emori M, Tamakawa M, Kaya M, Takada K, Murase K, Fujita C, Sato S, Takahashi R, Hatanaka KC, Sugita S, Hirano H, Yamashita T, Hasegawa T
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Journal Title
Pathology International
Volume: 67
Issue: 4
Pages: 222-224
DOI
Related Report
Peer Reviewed