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Establishment of the testing targeted for CD109 antigen in soft tissue sarcoma

Research Project

Project/Area Number 17K10974
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionSapporo Medical University

Principal Investigator

Emori Makoto  札幌医科大学, 医学部, 講師 (20580286)

Co-Investigator(Kenkyū-buntansha) 塚原 智英  札幌医科大学, 医学部, 准教授 (20404634)
清水 淳也  札幌医科大学, 医学部, 道兼任教員 (00826802)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords軟部肉腫 / CD109 / バイオマーカー / 骨・軟部腫瘍
Outline of Final Research Achievements

The purpose of this study is to establish the testing to detect early local recurrence or distant metastasis in soft tissue sarcomas. CD109 is a TGF-b co-receptor that regulates TGF-b receptor endocytosis and degrading. This relation may be associated with tumor proliferation, and immunohistochemical studies have demonstrated high level of expression in various cancers. We investigated the amount of CD109 antigen in serum in four patients who developed distant metastasis and compared the amount of CD109 between the preoperative and the distant metastasis phase. However, there were no significant change.

Academic Significance and Societal Importance of the Research Achievements

軟部肉腫においては、癌種のように再発・転移の早期発見を可能とする腫瘍マーカーは存在しない。我々は軟部肉腫において早期の再発・転移の検出を可能とするような血清マーカーの同定を目指した。特にCD109に着目した。しかしCD109においては、再発・転移時にも血清存在中のCD109抗原量に有意な差は認められず、再発・転移の検出を可能とするマーカーとはなりえなかった。今後新しいマーカーの同定が必要である。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (21 results)

All 2019 2018 2017

All Journal Article (21 results) (of which Peer Reviewed: 19 results,  Open Access: 5 results)

  • [Journal Article] Identification of Coiled-Coil Domain-Containing Protein 180 and Leucine-Rich Repeat-Containing Protein 4 as Potential Immunohistochemical Markers for Liposarcoma Based on Proteomic Analysis Using Formalin-Fixed, Paraffin-Embedded Tissue.2019

    • Author(s)
      Aoyama T, Takasawa A, Takasawa K, Ono Y, Emori M, Murata M, Hayasaka T, Fujitani N, Osanai M, Yamashita T, Hasegawa T, Sawada N.
    • Journal Title

      Am J Pathol.

      Volume: in press Issue: 5 Pages: 1015-1028

    • DOI

      10.1016/j.ajpath.2019.01.013

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combination of eribulin plus AKT inhibitor evokes synergistic cytotoxicity in soft tissue sarcoma cells2019

    • Author(s)
      Hayasaka Naotaka、Takada Kohichi、Nakamura Hajime、Arihara Yohei、Kawano Yutaka、Osuga Takahiro、Murase Kazuyuki、Kikuchi Shohei、Iyama Satoshi、Emori Makoto、Sugita Shintaro、Hasegawa Tadashi、Takasawa Akira、Miyanishi Koji、Kobune Masayoshi、Kato Junji
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 5759-5759

    • DOI

      10.1038/s41598-019-42300-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treatment outcome of chest wall soft tissue sarcomas: Analysis of prognostic factors2019

    • Author(s)
      Nakahashi Naoya、Emori Makoto、Tsuchie Hiroyuki、Nagasawa Hiroyuki、Sonoda Tomoko、Takada Kohichi、Miyajima Masahiro、Watanabe Atsushi、Shimada Yoichi、Yamashita Toshihiko
    • Journal Title

      Journal of Surgical Oncology

      Volume: 120 Issue: 7 Pages: 1235-1240

    • DOI

      10.1002/jso.25708

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exceptionally rapid response to pembrolizumab in a SMARCA4‐deficient thoracic sarcoma overexpressing PD‐L1: A case report2019

    • Author(s)
      Takada Kohichi、Sugita Shintaro、Murase Kazuyuki、Kikuchi Tomoki、Oomori Ginji、Ito Ryo、Hayasaka Naotaka、Miyanishi Koji、Iyama Satoshi、Ikeda Hiroshi、Kobune Masayoshi、Emori Makoto、Kato Junji、Hasegawa Tadashi
    • Journal Title

      Thoracic Cancer

      Volume: 10 Issue: 12 Pages: 2312-2315

    • DOI

      10.1111/1759-7714.13215

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Osteosarcoma‐initiating cells show high aerobic glycolysis and attenuation of oxidative phosphorylation mediated by LIN28B2019

    • Author(s)
      Mizushima Emi、Tsukahara Tomohide、Emori Makoto、Murata Kenji、Akamatsu Asuka、Shibayama Yuji、Hamada Shuto、Watanabe Yuto、Kaya Mitsunori、Hirohashi Yoshihiko、Kanaseki Takayuki、Nakatsugawa Munehide、Kubo Terufumi、Yamashita Toshihiko、Sato Noriyuki、Torigoe Toshihiko
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 1 Pages: 36-46

    • DOI

      10.1111/cas.14229

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognosis of Primary Osteosarcoma in Elderly Patients: A Comparison between Young and Elderly Patients2019

    • Author(s)
      Tsuchie Hiroyuki、Emori Makoto、Nagasawa Hiroyuki、Miyakoshi Naohisa、Murahashi Yasutaka、Shimizu Junya、Mizushima Emi、Yamashita Toshihiko、Shimada Yoichi
    • Journal Title

      Medical Principles and Practice

      Volume: 28 Issue: 5 Pages: 425-431

    • DOI

      10.1159/000500404

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic Impact of CD44 Expression in Patients With Myxofibrosarcoma2019

    • Author(s)
      TSUCHIE HIROYUKI、EMORI MAKOTO、MIYAKOSHI NAOHISA、NAGASAWA HIROYUKI、OKADA KYOJI、NANJYO HIROSHI、MURAHASHI YASUTAKA、MIZUSHIMA EMI、SHIMIZU JUNYA、YAMASHITA TOSHIHIKO、SHIMADA YOICHI
    • Journal Title

      In Vivo

      Volume: 33 Issue: 6 Pages: 2095-2102

    • DOI

      10.21873/invivo.11709

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Impact of Acridine Orange in Patients With Soft Tissue Sarcoma Treated With Marginal Resection2019

    • Author(s)
      TSUCHIE HIROYUKI、EMORI MAKOTO、MIYAKOSHI NAOHISA、NAGASAWA HIROYUKI、OKADA KYOJI、MURAHASHI YASUTAKA、MIZUSHIMA EMI、SHIMIZU JUNYA、YAMASHITA TOSHIHIKO、SHIMADA YOICHI
    • Journal Title

      Anticancer Research

      Volume: 39 Issue: 11 Pages: 6365-6372

    • DOI

      10.21873/anticanres.13849

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early Lymph Node Metastasis May Predict Poor Prognosis in Soft Tissue Sarcoma2019

    • Author(s)
      Emori Makoto、Tsuchie Hiroyuki、Nagasawa Hiroyuki、Sonoda Tomoko、Tsukamoto Arihiko、Shimizu Junya、Murahashi Yasutaka、Mizushima Emi、Takada Kohichi、Murase Kazuyuki、Iesato Kotoe、Igarashi Keita、Hori Tsukasa、Yamamoto Masaki、Sugita Shintaro、Miyakoshi Naohisa、Hasegawa Tadashi、Shimada Yoichi、Yamashita Toshihiko
    • Journal Title

      International Journal of Surgical Oncology

      Volume: 2019 Pages: 1-5

    • DOI

      10.1155/2019/6708474

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Giant cell-rich osteosarcoma of the vertebra with murine double minute chromosome 2- and cyclin-dependent kinase 4-positive and histone H3F3A mutant p.Gly34Trp-negative immunophenotypes.2018

    • Author(s)
      Ito Y, Sugita S, Segawa K, Sugawara T, Tsujiwaki M, Fujita H, Ono Y, Morita T, Emori M, Hasegawa T.
    • Journal Title

      Pathology International

      Volume: 68 Pages: 324-326

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The prognostic significance of surgical treatment for excessive elderly patients with soft tissue sarcoma2018

    • Author(s)
      Tsuchie Hiroyuki、Emori Makoto、Nagasawa Hiroyuki、Miyakoshi Naohisa、Murahashi Yasutaka、Mizushima Emi、Yamashita Toshihiko、Shimada Yoichi
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 23 Issue: 4 Pages: 775-782

    • DOI

      10.1007/s10147-018-1255-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan: from a questionnaire for JCOG 1610 study2018

    • Author(s)
      Urakawa H, Yonemoto T, Matsumoto S, Takagi T, Asanuma K, Watanuki M, Takemoto A, Naka N, Matsumoto Y, Kawai A, Kunisada T, Kubo T, Emori M, Hiraga H, Hatano H, Tsukushi S, Nishida Y, Akisue T, Morii T, Takahashi M, Nagano A, Yoshikawa H, Sato K, Kawano M, Hiraoka K, Tanaka K, Iwamoto Y, Ozaki T.
    • Journal Title

      World Journal of Surgical Oncology

      Volume: 16 Issue: 1 Pages: 162-162

    • DOI

      10.1186/s12957-018-1459-6

    • NAID

      120006502536

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prospective comparison of various radiological response criteria and pathological response to preoperative chemotherapy and survival in operable high-grade soft tissue sarcomas in the Japan Clinical Oncology Group study JCOG03042018

    • Author(s)
      Tanaka K, Ogawa G, Mizusawa J, Naka N, Kawai A, Takahashi M, Hiruma T, Matsumoto Y, Tsuchiya H, Nakayama R, Hatano H, Emori M, Hosaka M, Yoshida Y, Toguchida J, Abe S, Asanuma K, Yokoyama R, Hiraga H, Yonemoto T, Morii T, Matsumoto S, Nagano A, Yoshikawa H, Fukuda H, Ozaki T, Iwamoto Y.
    • Journal Title

      World Journal of Surgical Oncology

      Volume: 16 Issue: 1 Pages: 160-160

    • DOI

      10.1186/s12957-018-1462-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detection of specific gene rearrangements by fluorescence in situ hybridization in 16 cases of clear cell sarcoma of soft tissue and 6 cases of clear cell sarcoma-like gastrointestinal tumor2018

    • Author(s)
      Segawa Keiko、Sugita Shintaro、Aoyama Tomoyuki、Kubo Terufumi、Asanuma Hiroko、Sugawara Taro、Ito Yumika、Tsujiwaki Mitsuhiro、Fujita Hiromi、Emori Makoto、Hasegawa Tadashi
    • Journal Title

      Diagnostic Pathology

      Volume: 13 Issue: 1 Pages: 73-73

    • DOI

      10.1186/s13000-018-0752-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Secondary malignant giant cell tumor of bone with histone H3.3 mutation: A case series2018

    • Author(s)
      Emori Makoto、Nagoya Satoshi、Sugawara Masato、Mizushima Emi、Shimizu Junya、Murahashi Yasutaka、Murase Kazuyuki、Takada Kohichi、Sugita Shintaro、Takagi Michiaki、Hasegawa Tadashi、Yamashita Toshihiko
    • Journal Title

      Journal of Orthopaedic Science

      Volume: - Issue: 5 Pages: 926-930

    • DOI

      10.1016/j.jos.2018.11.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Arthroscopic Resection for Benign Fibrous Histiocytoma in the Epiphysis of the Femur2018

    • Author(s)
      Shimizu Junya、Emori Makoto、Okada Yohei、Hasegawa Tadashi、Yamashita Toshihiko
    • Journal Title

      Case Reports in Orthopedics

      Volume: 2018 Pages: 1-5

    • DOI

      10.1155/2018/8030862

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vascularised fibula grafts for reconstruction of extremity bone defects after resection of bone and soft tissue tumours: A single-institutional study of 49 patients.2017

    • Author(s)
      Emori M, Kaya M, Irifune H, Takahashi N, Shimizu J, Mizushima E, Murahashi Y, Yamashita T.
    • Journal Title

      Bone Joint Journal

      Volume: 99 Pages: 1237-1243

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] CD109は粘液線維肉腫の予後予測因子である2017

    • Author(s)
      江森誠人, 塚原智英, 杉田真太朗, 園田智子, 村橋靖崇, 清水淳也, 水島衣美, 相馬有, 佐々木幹人, 加谷光規, 名越智, 長谷川匡, 和田卓郎, 山下敏彦
    • Journal Title

      北海道整災外

      Volume: 59 Pages: 6-10

    • Related Report
      2017 Research-status Report
  • [Journal Article] Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.2017

    • Author(s)
      Shibayama Y, Tsukahara T, Emori M, Murata K, Mizushima E, Hirohashi Y, Kanaseki T, Nakatsugawa M, Kubo T, Yamashita T, Sato N, Torigoe T
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 9 Pages: 1739-1745

    • DOI

      10.1111/cas.13319

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distant metastasis in patients with myxofibrosarcoma.2017

    • Author(s)
      Tsuchie H, Kaya M, Nagasawa H, Emori M, Murahashi Y, Mizushima E, Yamashita T, Shimada Y.
    • Journal Title

      Upsala J Med Sci

      Volume: 122 Issue: 3 Pages: 1-4

    • DOI

      10.1080/03009734.2017.1356404

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Atypical presentation of primary pulmonary epithelioid sarcoma misdiagnosed as non-small cell lung cancer.2017

    • Author(s)
      Emori M, Tamakawa M, Kaya M, Takada K, Murase K, Fujita C, Sato S, Takahashi R, Hatanaka KC, Sugita S, Hirano H, Yamashita T, Hasegawa T
    • Journal Title

      Pathology International

      Volume: 67 Issue: 4 Pages: 222-224

    • DOI

      10.1111/pin.12503

    • Related Report
      2017 Research-status Report
    • Peer Reviewed

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Published: 2017-04-28   Modified: 2021-02-19  

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