| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this research, we investigated the relationship between mitochondrial biogenesis and joint destruction in RA. We investigated cell proliferation and MMP3/RANKL secretion by mitochondria biogenesis activated AICAR in RA-FLS. We also investigated joint destruction and inflammationby mitochondria biogenesis activated on AICAR in CIA-mice in vivo.
The mRNA expressions of mitochondrial biogenesis genes and mtDNA were enhanced by AICAR in RA-FLS. In addition, AICAR inhibited cell proliferation, MMP3 and RANKL production.In vivo study, AICAR inhibited arthritis score and joint destruction in CIA mice.AICAR inhibited joint destruction in CIA mice These results showed that enhancement of mitochondria biogenesis inhibited disease activity of RA.
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