Biomechanical study on femoral morphology with disease and age in Japanese using FEM simulation

• Project/Area Number: 17K11016
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Oita University
• Principal Investigator: Kaku Nobuhiro 大分大学, 医学部, 准教授 (10315335)
• Co-Investigator(Kenkyū-buntansha): 津村 弘 大分大学, 医学部, 教授 (30188627) ; 田畑 知法 大分大学, 医学部, 客員研究員 (80769406)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2018: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 日本人 / 大腿骨弯曲 / 性別 / 高齢 / 応力 / 大転子 / 頚体角 / FEM / 大腿骨 / 形態 / 有限要素モデル / 骨密度 / 応力解析 / 年齢 / 関節症 / 骨折 / バイオテクノロジー / 解剖学

Outline of Final Research Achievements

The purpose of this study was to analyze changes in femoral morphology with sex and aging for the elderly and young individuals in Japan using computer-based three-dimensional measurement with the CT data of 80. The femoral curvature originally differs depending on the sex and the becomes greater in anterior-lateral direction with age. The degree of curvature is larger in women than men. The three-dimensional femoral curvature leads to higher position of the greater trochanteric. Additionally, we investigated the effects of the femoral curvature and bone density of individuals on the stress distribution of proximal femur using the three-dimensional finite element method. The distribution and values of stress / strain tends to spread to the femoral trochanter region and be higher at there in elderly person. Therefore, it could be suggested that the greater anterolateral femoral curvature with aging might promote to generate the fracture of the femoral trochanter.

Academic Significance and Societal Importance of the Research Achievements

日本人の大腿骨弯曲に関する詳細な特徴と年齢に伴う変化及びそれに伴う大腿骨近位部における応力変化を明確にすることで，大腿骨頚部・転子部骨折の発生メカニズム（特徴）の新知見を見い出すことができた．年齢に伴う大腿骨の形状変化と応力変化に関する知見を基に，骨折の予防策を検討し，更に日本人の骨形状に幅広く合わせた人工関節等のインプラントや内固定材料の開発へフィードバックされることが期待される．

Research Products

• [Journal Article] Efficacy of Vitamin E for Mechanical Damage and Oxidation of Polyethylene Rim by Stem Neck Impingement. (2019)
  • Author(s): Nobuhiro Kaku, Hiroaki Tagomori, Hiroya Akase,et al.
  • Journal Title: Clin Biomech (Bristol, Avon) Volume: 68 Pages: 8-15
  • DOI: 10.1016/j.clinbiomech.2019.05.024
  • Peer Reviewed
• [Presentation] 若年者と高齢者の大腿骨弯曲に関する三次元的比較 (2019)
  • Author(s): 田籠泰明, 加来信広
  • Organizer: ４６回日本股関節学会学術集会